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PFAS Exposure and Thyroid Related Health Outcomes in Communities along the Cape Fear River, NC

北卡罗来纳州开普菲尔河沿岸社区的 PFAS 暴露与甲状腺相关健康结果

基本信息

批准号：
10337307
负责人：
JANE HOPPIN
金额：
$ 35.5万
依托单位：
NORTH CAROLINA STATE UNIVERSITY RALEIGH
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-02-28 至 2025-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10337307
关键词：
Address Adult Affect Age Aging Air Antibodies Back Biological Biomedical Research Blood Blood specimen Body mass index Characteristics Chemicals Child Cholesterol Clinic Visits Clinical Communication Communities Complex Complex Mixtures Data Data Set Development Ensure Environmental Health Excretory function Exposure to Fright Future Gender Health Health Personnel Heart Rate Human Individual Life Life Cycle Stages Measures Medical Metabolic Metabolism Nafion North Carolina Obesity Oral cavity Outcome Participant Pattern Persons Plants Poly-fluoroalkyl substances Population Population Heterogeneity Pregnant Women Privatization Protocols documentation Public Health Questionnaires Recording of previous events Regulation Reporting Research Personnel Research Project Grants Rivers Sample Size Sampling Sentinel Thyroid Diseases Thyroid Function Tests Thyroid Gland Thyroid Hormones Time Toxicokinetics United States Universities Urine Variant Water Water Pollutants Weight Work age group cohort community living community partnership community planning community science drinking water insight meetings predictive modeling prospective racial diversity reconstruction recruit superfund site thyroid disruption time use

项目摘要

ABSTRACT (Biomedical Research) Research Project 1 Project 1 is one of two Biomedical Research (BMR) Projects for the proposed “Center for Environmental and Health Effects of PFAS” being led by North Carolina State University (NC State). Per- and polyfluoroalkyl substances (PFAS) are common drinking water contaminants in NC and around the United States. Little is known about how long these chemicals stay in the body or what the human health impacts are. These chemicals have been detected in the drinking water of communities living along the Cape Fear River in NC. Working with three community groups along the Cape Fear River, we will evaluate PFAS exposure and thyroid health effects to people whose drinking water has been contaminated with PFAS. Disruption of thyroid hormones as well as metabolic outcomes such as obesity have been associated with PFAS in other populations. The three communities have exposure to different types of PFAS in their drinking water. Pittsboro, located on the Haw River in the upper region of the Cape Fear River basin, is exposed to historically used PFAS as a result of upstream use of firefighting foam, wastewater discharges, and land application of biosolids. The Fayetteville private well community is located near a fluorochemical plant that discharged PFAS to both air and water (Cape Fear River) since 1980; their wells are believed to be contaminated as a result of air transport. Wilmington, at the mouth of the Cape Fear River and downstream of the chemical plant, is exposed to both historically used PFAS (e.g., PFOA, PFOS) as well as a number of newly identified PFAS (e.g., GenX, Nafion byproduct 2). To study these diverse communities, we plan to recruit 1,200 individuals in the region (300 from Pittsboro, 200 from the Fayetteville private well community, and 700 from Wilmington) to evaluate how PFAS levels change over time, whether personal characteristics influence PFAS level as well as excretion from the body, and whether PFAS, either individually or as a group, influence thyroid outcomes. We plan to include individuals ages 6 and over who have lived in the region since July 2016. We will invite participants to clinic visits in Years 1 and 3 to collect blood and urine samples for PFAS and clinical analyses, administer questionnaires to obtain information on water use history, demographic characteristics, and medical and health outcomes. Working with our community partners, we will report back individual and community-level results on a regular basis. We will have Community Science Advisory Boards in each community to provide input to the study and ensure that the study investigators are well informed about community concerns. We anticipate finding PFAS mixtures in each community; we will use statistical approaches that allow us to evaluate individual PFAS while taking into account the complex mixture present. This study, with its complex mix of PFAS and racially diverse sample, will provide key insights to the human health implications of PFAS both in NC and around the world.

摘要