Alzheimer’s Disease Biomarker for Diagnosis and Prognosis
用于诊断和预后的阿尔茨海默病生物标志物
基本信息
- 批准号:10223184
- 负责人:
- 金额:$ 18.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-08-01 至 2022-05-31
- 项目状态:已结题
- 来源:
- 关键词:3&apos Untranslated RegionsAgeAlzheimer&aposs DiseaseAlzheimer&aposs disease brainAlzheimer&aposs disease diagnosisAlzheimer&aposs disease patientAlzheimer’s disease biomarkerAmyloidAmyloid beta-42Amyloid depositionAutophagocytosisBindingBiologicalBiological MarkersBloodBrainCellsCerebrospinal FluidClinical TrialsCystic FibrosisCystic Fibrosis sputumDataDegradation PathwayDementiaDepositionDeteriorationDiagnosisDiseaseDisease ProgressionEarly DiagnosisFutureGenesHealthHumanImmuneImpaired cognitionImpairmentIndividualLiquid substanceLungMeasuresMicroRNAsMonitorNerve DegenerationNeuronsOrganOrganellesPathogenesisPathogenicityPathologicPathologyPatientsPhenotypePhysiological ProcessesPlasmaPlayProcessProductionPrognosisPrognostic MarkerProteinsPublishingRoleSenile PlaquesSerumSputumTestingUntranslated RNAbasecystic fibrosis mousecystic fibrosis patientsdiagnostic biomarkerdisease diagnosisextracellularhuman subjecthyperphosphorylated tauimprovedinsightmembermicroRNA biomarkersmicrovesiclesneuron lossnovel markerpreventpulmonary functionresponsesexsmall moleculetau aggregationtherapeutic targettool
项目摘要
Abstract
Alzheimer's disease (AD) is the most common cause of dementia leading to irreversible neurodegeneration
and cognitive decline. Despite extensive efforts and numerous clinical trials of potential disease-modifying
therapies, there is yet no effective way to cure or prevent this disease. The core pathological hallmarks of AD
are extracellular deposits of the aggregated Aβ42 protein (amyloid plaques) and intracellular aggregates of
hyper-phosphorylated tau (neurofibrillary tangles). It is well established that defective autophagy in neuronal
cells contribute to disease pathology in AD. Autophagy is a physiological process and conserved degradation
pathway which is involved in the basal turnover of long-lived proteins and organelles. Several studies
demonstrated that autophagy plays an important role in amyloid clearance from the brain and that impaired
autophagy contribute to amyloid aggregation in AD brains. It is well accepted now that deterioration of
autophagy activity precedes the accumulation of Aβ42 and neuronal loss. In this project we will explore the
usage of a new marker for dysfunctional autophagy in AD.
摘要
项目成果
期刊论文数量(5)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Women Need to Be Advised About the Risks of Long-term Hormone Replacement Therapy.
女性需要了解长期激素替代疗法的风险。
- DOI:10.1212/wnl.0000000000201337
- 发表时间:2022
- 期刊:
- 影响因子:9.9
- 作者:Hershey,Linda;Tarawneh,Rawan
- 通讯作者:Tarawneh,Rawan
The Cornea: No Difference in the Wound Healing Response to Injury Related to Whether, or Not, There's a Bowman's Layer.
角膜:与是否有鲍曼的层相关的伤口愈合反应没有差异。
- DOI:10.3390/biom13050771
- 发表时间:2023-04-29
- 期刊:
- 影响因子:5.5
- 作者:
- 通讯作者:
Biomarkers: Our Path Towards a Cure for Alzheimer Disease.
- DOI:10.1177/1177271920976367
- 发表时间:2020
- 期刊:
- 影响因子:3.8
- 作者:Tarawneh R
- 通讯作者:Tarawneh R
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Amal O Amer其他文献
Caspase-4/11 exacerbates disease severity in SARS-CoV-2 infection by promoting inflammation and thrombosis
Caspase-4/11 通过促进炎症和血栓形成而加剧 SARS-CoV-2 感染的疾病严重程度
- DOI:
10.1101/2021.09.24.461743 - 发表时间:
2021 - 期刊:
- 影响因子:0
- 作者:
Mostafa Eltobgy;Ashley N. Zani;A. Kenney;Shady Z K Estfanous;Eunsoo Kim;Asmaa Badr;Cierra Carafice;Kylene P. Daily;Owen Whitham;Maciej Pietrzak;Amy Webb;Jeffrey Kawahara;Adrian C. Eddy;Parker J Denz;Mijia Lu;K. Mahesh;M. Peeples;Jianrong Li;Jian Zhu;Jianwen Que;Richard T Robinson;Oscar Rosas Mejia;R. Rayner;Luanne Hall;S. Seveau;M. Gavrilin;Andrea Tedeschi;Santiago Partida;Frank Roberto;Emily A. Hemann;Eman Abdelrazik;Adriana Forero;S. Nimjee;P. Boyaka;E. Cormet;J. Yount;Amal O Amer - 通讯作者:
Amal O Amer
Amal O Amer的其他文献
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{{ truncateString('Amal O Amer', 18)}}的其他基金
Mechanisms of lung and cardiac pathology in SARS-CoV-2 infections
SARS-CoV-2 感染中的肺和心脏病病理机制
- 批准号:
10649990 - 财政年份:2023
- 资助金额:
$ 18.88万 - 项目类别:
Targeting specific MicroRNA to alleviate Alzheimer’s Disease pathobiology
靶向特定 MicroRNA 缓解阿尔茨海默病病理学
- 批准号:
10666871 - 财政年份:2023
- 资助金额:
$ 18.88万 - 项目类别:
Rescue of CF phagocyte function with CFTR modulator therapy
CFTR 调节剂治疗拯救 CF 吞噬细胞功能
- 批准号:
10445615 - 财政年份:2022
- 资助金额:
$ 18.88万 - 项目类别:
Resue of CF phagocyte function with CFTR modulator therapy
CFTR调节剂治疗对CF吞噬细胞功能的恢复
- 批准号:
10797778 - 财政年份:2022
- 资助金额:
$ 18.88万 - 项目类别:
Host Responses to the Pore-Forming Toxin Listeriolysin O
宿主对成孔毒素李斯特菌溶血素 O 的反应
- 批准号:
10376220 - 财政年份:2021
- 资助金额:
$ 18.88万 - 项目类别:
Susceptibility determinants to Legionella pneumophila infection in smokers
吸烟者嗜肺军团菌感染的易感性决定因素
- 批准号:
10374758 - 财政年份:2021
- 资助金额:
$ 18.88万 - 项目类别:
Host Responses to the Pore-Forming Toxin Listeriolysin O
宿主对成孔毒素李斯特菌溶血素 O 的反应
- 批准号:
10589094 - 财政年份:2021
- 资助金额:
$ 18.88万 - 项目类别:
THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY
非典型炎症小体在先天免疫中的作用
- 批准号:
10427453 - 财政年份:2021
- 资助金额:
$ 18.88万 - 项目类别:
THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY
非典型炎症小体在先天免疫中的作用
- 批准号:
10625363 - 财政年份:2021
- 资助金额:
$ 18.88万 - 项目类别:
THE ROLE OF THE NON-CANONICAL INFLAMMASOME IN INNATE IMMUNITY
非典型炎症小体在先天免疫中的作用
- 批准号:
10310743 - 财政年份:2021
- 资助金额:
$ 18.88万 - 项目类别:
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