Core 1. Bioinformatics and statistics.

核心1.生物信息学和统计学。

• 批准号: 10223111
• 负责人: Patrik D'haeseleer
• 金额: $ 10.73万
• 依托单位: UNIVERSITY OF CALIF-LAWRNC LVRMR NAT LAB
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-08 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10223111
• 关键词: Amino Acid Sequence; Bioinformatics; Biological; Biometry; Chlamydia trachomatis; Code; Collaborations; Complex; Computational Biology; Computer Analysis; Consultations; Cryoelectron Microscopy; Data; Data Analyses; Data Reporting; Epitopes; Escherichia coli; Evolution; Genetic; Goals; Health; Immunology; In Vitro; Infection; Investments; Knowledge; Maps; Measures; Membrane Proteins; Outcome; Pathogenesis; Preclinical Testing; Procedures; Process; Protein Engineering; Proteins; Research Design; Research Project Grants; Sequence Alignment; Services; Statistical Data Interpretation; Statistical Methods; Structural Models; Synthetic Vaccines; System; Testing; Translating; Translations; Vaccines; Work; base; comparative; design; design and construction; efficacy outcomes; experimental study; first-in-human; in vivo; innovation; major outer membrane protein; nano; nanolipoprotein particles; novel; overexpression; preclinical trial; pressure; protein expression; safety outcomes; scaffold; statistics; success; technology development; three dimensional structure; vaccine evaluation

Bioinformatics and Statistics Core 1. ABSTRACT: The Center's overall scientific goal is to develop, validate, and perform pre-clinical testing of a suite of NanoScaffold-based Chlamydia trachomatis (Ct) vaccines. Successful pre-clinical trials would translate to first-in-human studies, with the potential to mitigate the health effects associated with Ct infection. The Bioinformatics and Statistics Core (BSC) will support the Center's goals by providing design and analysis leading to rigorous quantitative assessment of each step of the in vitro and in vivo studies carried out in Projects 1, 2, and 3, in close collaboration with the Immunology Core.

生物信息学和统计学核心1。摘要：中心的总体科学目标是发展， 验证并执行一套基于NanoScaffold的沙眼衣原体（Ct）的临床前测试 疫苗。成功的临床前试验将转化为首次人体研究，有可能减轻 与Ct感染相关的健康影响。生物信息学和统计学核心（BSC）将支持 中心的目标，通过提供设计和分析，导致严格的定量评估的每一步， 与免疫学核心密切合作，在项目1、2和3中进行了体外和体内研究。