Core 1. Bioinformatics and statistics.
Core 1. Bioinformatics and statistics.
批准号:
10458651
负责人:
Patrik D'haeseleer
金额:
$10.91万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-08-08 至 2024-07-31
关键词:
Amino Acid SequenceBioinformaticsBiometryChlamydia trachomatisCodeCollaborationsComplexComputational BiologyComputer AnalysisConsultationsCryoelectron MicroscopyDataData AnalysesData ReportingEpitopesEscherichia coliEvolutionGeneticGoalsHealthImmunologyIn VitroInfectionInvestmentsKnowledgeMapsMeasuresMembrane ProteinsOutcomePathogenesisPreclinical TestingProceduresProcessProtein EngineeringProteinsResearch DesignResearch Project GrantsSequence AlignmentServicesStatistical Data InterpretationStatistical MethodsStructural ModelsSynthetic VaccinesSystemTestingTranslatingTranslationsVaccinesWorkbasecomparativedesigndesign and constructionefficacy outcomesexperimental studyfirst-in-humanin vivoinnovationmajor outer membrane proteinnanonanolipoprotein particlesnoveloverexpressionpreclinical trialpressureprotein expressionsafety outcomesscaffoldstatisticssuccesstechnology developmentthree dimensional structurevaccine evaluation
中文摘要
生物信息学和统计学核心1。摘要:中心的总体科学目标是发展,
验证并执行一套基于NanoScaffold的沙眼衣原体(Ct)的临床前测试
疫苗。成功的临床前试验将转化为首次人体研究,有可能减轻
与Ct感染相关的健康影响。生物信息学和统计学核心(BSC)将支持
中心的目标,通过提供设计和分析,导致严格的定量评估的每一步,
与免疫学核心密切合作,在项目1、2和3中进行了体外和体内研究。
英文摘要
Bioinformatics and Statistics Core 1. ABSTRACT: The Center's overall scientific goal is to develop,
validate, and perform pre-clinical testing of a suite of NanoScaffold-based Chlamydia trachomatis (Ct)
vaccines. Successful pre-clinical trials would translate to first-in-human studies, with the potential to mitigate
the health effects associated with Ct infection. The Bioinformatics and Statistics Core (BSC) will support the
Center's goals by providing design and analysis leading to rigorous quantitative assessment of each step of the
in vitro and in vivo studies carried out in Projects 1, 2, and 3, in close collaboration with the Immunology Core.
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Core 1. Bioinformatics and statistics.
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批准号:10223111
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项目类别:
-
资助金额:$10.73万
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财政年份:2019
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负责人:Patrik D'haeseleer
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依托单位:
海外基金