Application for Supplemental Funding from HUBMAP

向 HUBMAP 申请补充资金

• 批准号: 10228511
• 负责人: GARRY P NOLAN
• 金额: $ 7.5万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10228511
• 关键词: 3-Dimensional; Antibodies; Biological Assay; Cell Nucleus; Cells; Colon; Data; Data Set; Duodenum; Epigenetic Process; Epitopes; Funding; Genetic Transcription; Goals; Heart; Histologic; Human BioMolecular Atlas Program; Image; Intestines; Large Intestine; Patients; Population; Proteins; RNA; Rectum; Running; Small Intestines; Technology; Tissues; cell type; ileum; jejunum; protein biomarkers; transcriptome sequencing; transcriptomics

Project Summary/Abstract The Stanford Tissue Mapping Center within HuBMAP is leading the 3D single cell characterization of bowel and colon tissues through highly multi-plexed `omic' profiling and histological and antibody- tagged epitope imaging. Our goal is to identify the single cell gene transcription profiles that establish the identity of each cellular population in colon and small bowel tissue and understand the relevance of the spatial organization of different cell types to bowel function.

项目总结/摘要 HuBMAP内的斯坦福大学组织绘图中心正在领导3D单细胞表征， 肠和结肠组织，通过高度多重的“组学”分析和组织学和抗体， 标记表位成像。我们的目标是确定单细胞基因转录谱，建立 结肠和小肠组织中每种细胞群的身份，并了解 不同细胞类型的空间组织对肠功能的影响。