Using Neuroeconomics to Characterize State-Based Increases and Decreases in Alcohol Value

利用神经经济学来描述基于状态的酒精值的增加和减少

• 批准号: 10229182
• 负责人: Michael T. Amlung
• 金额: $ 28.26万
• 依托单位: UNIVERSITY OF KANSAS LAWRENCE
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10229182
• 关键词: Acute; Address; Adult; Affective; Alcohol consumption; Alcoholic beverage heavy drinker; Alcohols; Anterior; Area; Awareness; Behavioral; Beverages; Brain; Clinical; Conflict (Psychology); Cost Measures; Costs and Benefits; Cues; Decision Making; Economics; Exhibits; Exposure to; Female; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Individual; Instruction; Insula of Reil; Interoception; Literature; Measures; Methods; Modeling; Monitor; Motivation; Network-based; Neurobiology; Neurosciences; Pathologic; Pattern; Prediction of Response to Therapy; Prefrontal Cortex; Price; Process; Property; Protocols documentation; Psychology; Public Health; Recovery; Relapse; Research; Rewards; Sampling; Schools; Severities; Sex Differences; Variant; Ventral Striatum; Work; alcohol cue; alcohol demand; alcohol exposure; alcohol measurement; alcohol misuse; alcohol research; alcohol response; alcohol use disorder; base; behavioral economics; biobehavior; clinically relevant; cognitive neuroscience; design; drinking; executive function; indexing; male; neural correlate; neural network; neural patterning; neuroeconomics; neuroimaging; novel; phase change; preference; relating to nervous system; response; support network; trait; treatment response

PROJECT SUMMARY/ABSTRACT Neuroeconomics integrates concepts and methods from psychology, economics, and cognitive neuroscience to understand the neurobiological foundations of decision making, and has been increasingly applied to understanding alcohol use disorder (AUD). A novel application of neuroeconomics is the study of alcohol demand, or the value of alcohol as measured by cost-benefit preferences. Alcohol demand paradigms have considerable ecological validity by measuring the impact of internal and external influences on alcohol decision-making, such as price, environmental cues, affective states, or external contingencies. Behaviorally, alcohol demand is elevated among individuals with higher levels of alcohol misuse and predicts treatment response. Alcohol demand also exhibits state-like properties, including increases following exposure to alcohol-related cues and decreases in the presence of significant next-day responsibilities. The overall goal of the proposed studies is to characterize the neural activity that subserves these established behavioral findings using a novel functional MRI paradigm. The first aim is to examine the patterns of neural activation underlying increases in the value of alcohol in response to alcohol cues. To do so, the first study will use a within-subjects design to identify differences in neural activity associated with demand decisions following a validated in- scanner cue exposure protocol consisting of exposure to neutral beverage cues and exposure to alcohol beverage cues in a sample of adult heavy drinkers. The second aim is to investigate the changes in neural activity associated with decreases in the value of alcohol in response to next day responsibilities. To do so, a second study will use a within-subjects design, comparing demand-related neural activity following a standard instructional set and an instructional set that imposes a significant work-related responsibility the next day. Using a novel neuroeconomics approach, these studies combine a highly ecologically-valid alcohol demand paradigm with two experimental manipulations that model clinically-relevant influences on drinking decisions. Studying these contextual influences may help clarify the neural signatures that underlie drinking moderation vs. unconstrained drinking, and how these processes are impacted by AUD. If successful, these studies will provide a foundation for examining neural predictors of successful recovery or response to treatment vs. relapse. More broadly, findings from these studies have high potential to significantly enhance the clinical relevance of alcohol neuroscience.

项目总结/文摘