Molecular Pharmacology Training Program

分子药理学培训项目

• 批准号: 10398169
• 负责人: JAMES K CHEN
• 金额: $ 41.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398169
• 关键词: Molecular; Pharmacology; Training Programs

Pharmacology is at a crossroads. Although technological advances in chemistry and biology have transformed drug discovery, our ability to develop new therapeutics has lagged behind our clinical needs. This gap reflects a disconnect between basic science discovery and translational research, and addressing this challenge will require scientists who can bridge these two areas. Toward this goal, the Stanford Molecular Pharmacology Training Program (MPTP) aims to empower predoctoral students across the biosciences with specialized training in drug discovery and development. The MPTP is founded on the rich history of pharmacology research and education at Stanford, and it now transcends conventional academic boundaries. Our training program draws upon an outstanding group of 26 highly collaborative Stanford faculty from multiple departments, and it builds upon the strength of SPARK, a translational research initiative that was created at Stanford in 2006. In addition to their independent research with MPTP faculty, our trainees receive formal course work in drug discovery, and they attend weekly presentations by SPARK-affiliated experts in pharma/biotech, patent law, venture capital, clinical medicine, and other areas related to therapeutic development. MPTP students also participate in summer biotech internships and clinical shadowing opportunities, supplementing their academic training with industrial and clinical experiences. These training activities are integrated with courses on the responsible conduct of research, rigor, and reproducibility, weekly student/faculty research forums, annual retreats, grant writing and science communication workshops, and outreach opportunities. Our predoctoral students are also encouraged to propose translational projects, which are reviewed and funded by SPARK on a competitive basis. These team-based projects provide hands- on, real-world experience in therapeutic development and direct interactions with industry veterans and experts. Our program carefully tracks student research progress, faculty mentorship, and program effectiveness to enable the MPTP to continually evolve to meet its educational mission. To train scientific leaders and innovators who will impact communities throughout the United States, we have also established recruitment and retention strategies to foster student diversity, leveraging Stanford resources and mobilizing the MPTP community. Through its innovative curriculum and partnerships with SPARK and industry, the MPTP will impart its students with rigorous training in basic science and an understanding of drug discovery and development. Graduates of our training program will be uniquely able to translate fundamental discoveries into clinical advances, and they will be well- positioned to become scientific leaders in academia, industry, government, and other sectors.

药理学正处于十字路口。尽管化学和生物学的技术进步已经改变了 药物发现，我们开发新疗法的能力已经落后于我们的临床需求。这一差距反映了 基础科学发现和转化研究之间的脱节，解决这一挑战将需要 科学家们可以将这两个领域联系起来。为了实现这一目标，斯坦福大学分子药理学培训计划 （MPTP）旨在为生物科学领域的博士前学生提供药物发现和 发展 MPTP建立在斯坦福大学丰富的药理学研究和教育历史的基础上，现在它 超越了传统的学术界限。我们的培训计划借鉴了一个优秀的26个高度 协作斯坦福大学教师来自多个部门，它建立在SPARK的力量，一个翻译 这是2006年在斯坦福大学创立的一个研究项目。除了他们与MPTP教师的独立研究， 我们的学员接受药物发现的正式课程，他们参加SPARK附属的每周报告会。 制药/生物技术、专利法、风险投资、临床医学和其他与治疗相关领域的专家 发展MPTP学生还参加暑期生物技术实习和临床跟踪机会， 用工业和临床经验补充他们的学术训练。 这些培训活动与关于负责任地进行研究、严谨性和 再现性，每周学生/教师研究论坛，年度务虚会，赠款写作和科学交流 讲习班和外联机会。我们的博士前学生也鼓励提出翻译 这些项目由SPARK在竞争的基础上审查和资助。这些团队项目提供了手- 在治疗开发方面的实际经验以及与行业资深人士和专家的直接互动。我们 该计划仔细跟踪学生的研究进展，教师指导和计划的有效性，使 MPTP不断发展，以满足其教育使命。培养科学领导者和创新者， 在美国各地的社区，我们还建立了招聘和保留战略，以促进 学生的多样性，利用斯坦福大学的资源和动员MPTP社区。 通过其创新的课程和与SPARK和行业的合作伙伴关系，MPTP将传授给学生 在基础科学和药物发现和开发的理解严格的培训。我们的毕业生 培训计划将是唯一能够将基础发现转化为临床进展，他们将很好地- 定位成为学术界，工业界，政府和其他部门的科学领导者。