Molecular Pharmacology Training Program

分子药理学培训项目

• 批准号: 10398169
• 负责人: JAMES K CHEN
• 金额: $ 41.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398169
• 关键词: Molecular; Pharmacology; Training Programs

Pharmacology is at a crossroads. Although technological advances in chemistry and biology have transformed drug discovery, our ability to develop new therapeutics has lagged behind our clinical needs. This gap reflects a disconnect between basic science discovery and translational research, and addressing this challenge will require scientists who can bridge these two areas. Toward this goal, the Stanford Molecular Pharmacology Training Program (MPTP) aims to empower predoctoral students across the biosciences with specialized training in drug discovery and development. The MPTP is founded on the rich history of pharmacology research and education at Stanford, and it now transcends conventional academic boundaries. Our training program draws upon an outstanding group of 26 highly collaborative Stanford faculty from multiple departments, and it builds upon the strength of SPARK, a translational research initiative that was created at Stanford in 2006. In addition to their independent research with MPTP faculty, our trainees receive formal course work in drug discovery, and they attend weekly presentations by SPARK-affiliated experts in pharma/biotech, patent law, venture capital, clinical medicine, and other areas related to therapeutic development. MPTP students also participate in summer biotech internships and clinical shadowing opportunities, supplementing their academic training with industrial and clinical experiences. These training activities are integrated with courses on the responsible conduct of research, rigor, and reproducibility, weekly student/faculty research forums, annual retreats, grant writing and science communication workshops, and outreach opportunities. Our predoctoral students are also encouraged to propose translational projects, which are reviewed and funded by SPARK on a competitive basis. These team-based projects provide hands- on, real-world experience in therapeutic development and direct interactions with industry veterans and experts. Our program carefully tracks student research progress, faculty mentorship, and program effectiveness to enable the MPTP to continually evolve to meet its educational mission. To train scientific leaders and innovators who will impact communities throughout the United States, we have also established recruitment and retention strategies to foster student diversity, leveraging Stanford resources and mobilizing the MPTP community. Through its innovative curriculum and partnerships with SPARK and industry, the MPTP will impart its students with rigorous training in basic science and an understanding of drug discovery and development. Graduates of our training program will be uniquely able to translate fundamental discoveries into clinical advances, and they will be well- positioned to become scientific leaders in academia, industry, government, and other sectors.

药理学正处于十字路口。尽管化学和生物方面的技术进步已经改变了 在药物发现方面，我们开发新疗法的能力已经落后于我们的临床需求。这一差距反映了 基础科学发现和转化研究之间的脱节，解决这一挑战将需要 能够在这两个领域架起桥梁的科学家。为了实现这一目标，斯坦福大学分子药理学培训项目 (MPTP)旨在通过药物发现和药物开发方面的专门培训，增强生物科学领域的博士前学生能力 发展。 MPTP是建立在斯坦福大学丰富的药理学研究和教育历史上的，现在它 超越了传统的学术界限。我们的培训计划吸引了26人的优秀团队 来自多个部门的协作斯坦福教师，它建立在Spark的优势之上，Spark是一种翻译 斯坦福大学于2006年创建的研究计划。除了他们与MPTP教职员工的独立研究外， 我们的实习生接受药物发现方面的正式课程工作，他们每周都会参加Spark附属公司的报告。 制药/生物技术、专利法、风险投资、临床医学和其他与治疗相关的领域的专家 发展。MPTP学生还参加暑期生物技术实习和临床跟踪机会， 用工业和临床经验补充他们的学术培训。 这些培训活动与负责任的研究、严谨和 可重现性，每周学生/教师研究论坛，年度务虚会，拨款撰写和科学交流 讲习班和外展机会。我们的博士前学生也被鼓励提出翻译建议 项目，由Spark在竞争的基础上进行审查和资助。这些基于团队的项目提供了手- 在治疗开发方面的实际经验以及与行业资深人士和专家的直接互动。我们的 该计划仔细跟踪学生的研究进展、教师指导和计划有效性，以使 MPTP将不断发展，以满足其教育使命。培养将产生影响的科学领导者和创新者 在美国各地的社区，我们还制定了招聘和留住战略，以促进 学生多样性，利用斯坦福大学的资源，动员MPTP社区。 通过其创新的课程以及与Spark和行业的合作伙伴关系，MPTP将教授其学生 受过严格的基础科学培训，对药物发现和开发有一定的了解。我们的毕业生 培训计划将独一无二地能够将基础发现转化为临床进步，而且它们将很好地- 定位成为学术界、工业界、政府和其他领域的科学领袖。