Molecular Pharmacology Training Program

分子药理学培训项目

• 批准号: 10398169
• 负责人: JAMES K CHEN
• 金额: $ 41.63万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398169
• 关键词: Molecular; Pharmacology; Training Programs

Pharmacology is at a crossroads. Although technological advances in chemistry and biology have transformed drug discovery, our ability to develop new therapeutics has lagged behind our clinical needs. This gap reflects a disconnect between basic science discovery and translational research, and addressing this challenge will require scientists who can bridge these two areas. Toward this goal, the Stanford Molecular Pharmacology Training Program (MPTP) aims to empower predoctoral students across the biosciences with specialized training in drug discovery and development. The MPTP is founded on the rich history of pharmacology research and education at Stanford, and it now transcends conventional academic boundaries. Our training program draws upon an outstanding group of 26 highly collaborative Stanford faculty from multiple departments, and it builds upon the strength of SPARK, a translational research initiative that was created at Stanford in 2006. In addition to their independent research with MPTP faculty, our trainees receive formal course work in drug discovery, and they attend weekly presentations by SPARK-affiliated experts in pharma/biotech, patent law, venture capital, clinical medicine, and other areas related to therapeutic development. MPTP students also participate in summer biotech internships and clinical shadowing opportunities, supplementing their academic training with industrial and clinical experiences. These training activities are integrated with courses on the responsible conduct of research, rigor, and reproducibility, weekly student/faculty research forums, annual retreats, grant writing and science communication workshops, and outreach opportunities. Our predoctoral students are also encouraged to propose translational projects, which are reviewed and funded by SPARK on a competitive basis. These team-based projects provide hands- on, real-world experience in therapeutic development and direct interactions with industry veterans and experts. Our program carefully tracks student research progress, faculty mentorship, and program effectiveness to enable the MPTP to continually evolve to meet its educational mission. To train scientific leaders and innovators who will impact communities throughout the United States, we have also established recruitment and retention strategies to foster student diversity, leveraging Stanford resources and mobilizing the MPTP community. Through its innovative curriculum and partnerships with SPARK and industry, the MPTP will impart its students with rigorous training in basic science and an understanding of drug discovery and development. Graduates of our training program will be uniquely able to translate fundamental discoveries into clinical advances, and they will be well- positioned to become scientific leaders in academia, industry, government, and other sectors.

药理学处于十字路口。尽管化学和生物学方面的技术进步已经改变 药物发现，我们开发新治疗剂的能力落后于我们的临床需求。这个差距反映了 基础科学发现与翻译研究之间的连接，并应对这一挑战将需要 可以桥接这两个领域的科学家。为了实现这一目标，斯坦福分子药理学培训计划 （MPTP）旨在通过药物发现和 发展。 MPTP建立在斯坦福大学药理学研究和教育悠久的历史上，现在 超越常规的学术界限。我们的培训计划借鉴了26个杰出的团体 来自多个部门的斯坦福大学的协作，它建立在Spark的实力上，这是一种翻译 研究计划于2006年在斯坦福大学制定。除了与MPTP教师的独立研究外， 我们的学员接受了在药物发现方面的正式课程工作，他们通过Spark隶属的每周演讲 药品/生物技术，专利法，风险投资，临床医学和其他与治疗方面的专家 发展。 MPTP学生还参加夏季生物技术实习和临床阴影机会， 通过工业和临床经验来补充他们的学术培训。 这些培训活动与负责研究，严谨性和 可重复性，每周的学生/教师研究论坛，年度务虚会，赠款写作和科学传播 讲习班和宣传机会。还鼓励我们的专业学生提出翻译 项目在竞争的基础上审查和资助。这些基于团队的项目提供了动力 - 关于治疗发展和与行业退伍军人和专家的直接互动方面的现实经验。我们的 计划仔细跟踪学生的研究进度，教师指导和计划有效性，以实现 MPTP不断发展以实现其教育任务。培训将影响影响的科学领袖和创新者 美国各地的社区，我们还建立了招聘和保留策略以促进 学生多样性，利用斯坦福大学的资源并动员MPTP社区。 通过其创新的课程和与Spark和行业的合作伙伴关系，MPTP将授予其学生 经过严格的基础科学培训以及对药物发现和开发的理解。我们的毕业生 培训计划将具有独特的能力，可以将基本发现转化为临床进展，它们将是很好的 成为学术界，工业，政府和其他部门的科学领导者。