Development of Mechanisms Underlying Human Motor Learning

人类运动学习机制的发展

• 批准号: 10397668
• 负责人: Amy J. Bastian
• 金额: $ 68.67万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2029-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10397668
• 关键词: Affect; Age; Brain; Child; Childhood; Cognitive; Complex; Data; Dependence; Development; Disease; Environment; Flowcharts; Gender; Home; Human; Injury; Laboratories; Learning; Lesion; Methods; Motor; Movement; Nervous System Trauma; Neurologic; Neurosciences; Persons; Process; Resolution; Rewards; Signal Transduction; Social Well-Being; Testing; Therapeutic; Time; TimeLine; Training; Video Games; Well in self; base; experience; motor learning; success

Movement abilities affect a child’s physical, social and emotional well-being, as well as their educational success—all of which can last a lifetime. Movement is fundamental to the development of abilities across domains (motor, cognitive), because it underlies a child’s ability to explore and interact with the environment and other people. How children learn movement is a complex process that changes with development, experience and injury. It depends on a suite of interacting brain mechanisms that are driven by different signals (e.g. reward, error), have different learning rates, retention capacities, contextual dependencies and vulnerabilities to neurological damage. A key gap in human neuroscience is our limited understanding of this complex interplay. We propose to leverage recently developed home-based experimental tasks and new laboratory methods to generate high resolution time courses for different components of childhood motor learning, and then determine how they are affected by neurological lesions. With these data we can create a detailed flowchart of movement learning capacity and the effects of disease, as a function of age and developmental markers. This would provide the comprehensive understanding required to generate tailored therapeutic training strategies targeted to age, developmental maturity, gender, and disease state.

运动能力影响儿童的身体、社交和情感健康，也影响他们的教育 成功--所有这些都可以持续一生。运动是能力发展的基础。 领域(运动、认知)，因为它是儿童探索和与环境互动的能力的基础 其他人。儿童如何学习动作是一个复杂的过程，会随着发展和经验的变化而变化 和受伤。它依赖于一套由不同信号驱动的相互作用的大脑机制(例如，奖励， 错误)，具有不同的学习率、保留能力、上下文依赖关系和脆弱性 神经损伤。人类神经科学中的一个关键空白是我们对这种复杂的相互作用的有限理解。 我们建议利用最近开发的基于家庭的实验任务和新的实验室方法来 为儿童运动学习的不同组成部分生成高分辨率的时间课程，然后确定 他们是如何受到神经损伤的影响的。有了这些数据，我们可以创建一个详细的运动流程图 学习能力和疾病的影响，作为年龄和发育标志物的函数。这将提供 产生针对年龄的量身定做的治疗培训战略所需的全面了解， 发育成熟度、性别和疾病状态。