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Fatigue and Smoking Relapse

疲劳和吸烟复发

基本信息

批准号：
10398856
负责人：
Kara Manning
金额：
$ 3.74万
依托单位：
UNIVERSITY OF HOUSTON
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2023-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10398856
关键词：
Abstinence Adult American Behavior Cessation of life Development Fatigue Hour Individual Individual Differences Knowledge Label Laboratories Maintenance Medical Modeling Nicotine Outcome Participant Patient Self-Report Persons Pharmacological Treatment Pharmacology Population Prevalence Process Public Health Relapse Reporting Research Risk Role Severities Smoke Smoker Smoking Smoking Behavior Smoking Cessation Intervention Speed Stress Subgroup Symptoms Testing United States Withdrawal Work analog cigarette smoke cigarette smoking clinically significant combat fatigue craving deprivation experience high risk population innovation meetings multimodality non-smoker novel precision medicine preventable death programs psychological distress psychosocial smoking abstinence smoking cessation smoking prevalence smoking relapse smoking-related disease therapy development trait

项目摘要

Project Summary The majority of smokers (68%) in the US report a desire to quit 1 and most (55.4%) of the 34 million Americans who smoke make a serious quit attempt each year, primarily on their own (i.e., self-guided quit) and to a lesser extent, with assistance from formal treatment 2. Unfortunately, less than 5% of cessation attempters remain abstinent for 6 or more months 3. Smoking prevalence has stabilized as the remaining population becomes increasingly representative of “at-risk smokers” who are unable to quit 4. Yet, there remains little understanding of the subgroups of "at-risk smokers" and the processes governing relapse among them 5. The experience of prolonged fatigue may be one underrecognized but highly common problem that may help in understanding smoking maintenance and relapse. Prolonged fatigue is defined as self-reported, persistent fatigue lasting 1 month or longer 6, 7. In the US, almost 25% of the general adult population has had fatigue lasting 2 weeks or longer 8; the majority of these persons (59% to 64%) reported that their fatigue has no defined medical cause 8, 9. Emerging work suggests that prolonged fatigue is common among smokers 10 and that nicotine may be used to combat fatigue 11. However, there has been no research directed on prolonged fatigue in relation to actual smoking behavior. Therefore, the present proposal seeks to better understand whether and how individual differences in severity of prolonged fatigue predict smoking behavior during an experimental relapse analogue task. The association between prolonged fatigue severity and smoking behavior during the task, however, may depend on whether individuals are in a period of abstinence as the experience of withdrawal during abstinence may be particularly aversive for those with higher fatigue symptoms, leading to greater urges and lapse behavior for these individuals. That is, even though prolonged fatigue severity has been shown to have trait-like qualities 12, it also has been shown to be sensitive to state effects 13. Consequently, the predictive power of prolonged fatigue severity may be particularly (or perhaps only) evident while the individual is experiencing the stress induced by substance deprivation. Therefore, the current project requires that participants attend two counterbalanced experimental sessions – (1) smoking deprivation (16 hours of smoking abstinence) and (2) smoking as usual – during which fatigue severity during the relapse analogue task will be assessed. The proposed project has a great deal of public health significance because it can help guide the development of novel psychosocial or pharmacologic smoking cessation interventions that target a unique and underrecognized vulnerability process (fatigue) that results in poorer cessation outcomes and ultimately help smokers with prolonged fatigue quit.

项目摘要在美国，大多数吸烟者（68%）表示有戒烟的愿望，3400万吸烟者中的大多数（55.4%）吸烟的美国人每年都会认真尝试戒烟，主要是靠自己（即，自我引导退出）和在较小程度上，在正规治疗的帮助下2.不幸的是，只有不到5%的戒烟者保持禁欲6个月或以上3.吸烟率已经稳定，越来越多地成为无法戒烟的“高危吸烟者”的代表。然而，了解“高危吸烟者”的亚组及他们复吸的过程的长期疲劳的经历可能是一个未被认识到但非常常见的问题，可能有助于了解吸烟的维持和复发。长期疲劳被定义为自我报告的持续疲劳持续1个月或更长时间6，7。在美国，几乎25%的成年人有持续2周或更长时间的疲劳;其中大多数人人（59%至64%）报告说，他们的疲劳没有明确的医疗原因8，9。新的研究表明，长期疲劳在吸烟者中是常见的10，尼古丁可用于对抗疲劳11。然而，目前还没有针对长期疲劳与实际吸烟行为之间关系的研究。因此，本提案旨在更好地了解严重程度的个体差异是否以及如何长期疲劳的预测吸烟行为在一个实验性的复发模拟任务。协会然而，长期疲劳严重程度和任务期间吸烟行为之间的关系可能取决于个人处于禁欲期，因为禁欲期间的戒断经历可能特别对于那些有较高疲劳症状的人来说，这是令人厌恶的，导致这些人更大的冲动和失误行为。个体也就是说，即使长时间的疲劳严重性已被证明具有类似特质的品质12，已被证明是敏感的状态效应13。因此，长期疲劳的预测能力严重性可能在个体经历由以下引起的压力时特别（或可能仅）明显：物质匮乏因此，目前的项目要求参与者参加两个平衡的实验阶段-（1）禁止吸烟（戒烟16小时）和（2）照常吸烟- 在此期间将评估复发模拟任务期间的疲劳严重程度。拟议的项目具有很大的公共卫生意义，因为它可以帮助指导开发新的社会心理或药物戒烟干预措施，未被充分认识的脆弱性过程（疲劳），导致戒烟效果较差，最终有助于长期疲劳的吸烟者戒烟。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Emotion dysregulation, fatigue, and electronic cigarette expectancies.

DOI：
10.1080/16506073.2020.1819868
发表时间：
2021-03
期刊：
Cognitive behaviour therapy
影响因子：
4.7
作者：
Zvolensky MJ;Manning K;Garey L;Alfano CA;Mayorga NA;Peraza N
通讯作者：
Peraza N

Anxiety Sensitivity Moderates the Impact of COVID-19 Perceived Stress on Anxiety and Functional Impairment.

DOI：
10.1007/s10608-021-10207-7
发表时间：
2021
期刊：
Cognitive therapy and research
影响因子：
2.8
作者：
Manning K;Eades ND;Kauffman BY;Long LJ;Richardson AL;Garey L;Zvolensky MJ;Gallagher MW
通讯作者：
Gallagher MW

The Role of Anxiety Sensitivity in terms of Weight-related Impairment and Fatigue Severity among Adults with Obesity and Chronic Low Back Pain.