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Small Animal Imaging Lab Core

小动物成像实验室核心

基本信息

批准号：
10230155
负责人：
David L Morse
金额：
$ 0.45万
依托单位：
H. LEE MOFFITT CANCER CTR & RES INST
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-02-18 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10230155
关键词：
Anatomy Animal Cancer Model Animal Housing Animal Model Animal Technicians Animals Award Basic Science Behavior Beta Particle Bioluminescence Blood flow Cancer Biology Cancer Center Cancer Center Support Grant Cancer Model Clinic Clinical Trials Collaborations Complex Consultations Core Facility Detection Development Doctor of Philosophy Educational Activities Effectiveness Ensure Experimental Designs Florida Fluorescence Functional Imaging Funding Goals Grant Hand Hypoxia IACUC Image Imaging technology In Situ Individual Journals Laboratories Location Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Management Information Systems Manuscripts Metabolic Methodology Microscopy Modality Modeling Multimodal Imaging Mus Neoplasm Metastasis Nuclear Peer Review Photons Pilot Projects Positron-Emission Tomography Preparation Procedures Protocols documentation Publications Radiochemistry Reproducibility of Results Research Resolution Resources Rodent Roentgen Rays Scanning Schedule Scientist Secure Services System Technology Time Training Translating Tumor Biology Ultrasonography X-Ray Computed Tomography anatomic imaging animal care animal imaging animal resource bioluminescence imaging clinical practice data management density design ex vivo imaging experience feature extraction fluorescence imaging glucose metabolism glucose uptake imaging approach imaging capabilities imaging facilities imaging modality imaging study in vivo in vivo imaging instrument instrumentation intravital microscopy meetings member metabolic imaging microCT molecular imaging new technology novel strategies pre-clinical pre-clinical research preclinical study programs quality assurance quantitative imaging repository response serial imaging single photon emission computed tomography tumor ultrasound microscopy

项目摘要

PROJECT SUMMARY The goal of the Small Animal Imaging Lab (SAIL) Core Facility is to provide state-of-the art imaging resources to Moffitt Cancer Center (MCC) members for their basic and translational preclinical studies of rodent cancer models. The SAIL has expanded its services to offer a wide array of multimodality imaging, including MRI, hyperpolarized MRI, CT, PET, SPECT, beta particle, ultrasound, bioluminescence, and fluorescence imaging. These systems allow members to follow tumor development, progression, metastasis and the response to therapy in animal models using quantitative imaging. SAIL provides detection at high spatial resolution of a number of functional, metabolic and anatomical changes, including hypoxia, pH, temporal sensitivity to cellular density, blood flow, and glucose uptake and metabolism. These parameters can be quantified using SAIL's expertise in image feature extraction and analysis to generate an integrated analysis of tumor biology in situ. Animal tumor models are critical for understanding the biology of cancer and the complex responses of distinct tumor types to therapy. Imaging of these animal subjects is a core technology that can precisely define cancer behaviors. Further, as most of these modalities provided by the SAIL are available in the clinic, results with animal tumor models can be readily translated into clinical trials and clinical practice. Multimodality imaging is the key focus of the facility as this provides a broad range of technologies that assist members with their basic and pre-clinical research programs. Over the next funding period, the Specific Aims of the SAIL Core are to: Aim 1. Assist members in experimental design, interpretation of results, and manuscript and grant preparation. Aim 2. Provide and expand in vivo and ex vivo imaging and analytical technologies for research involving small animal cancer models. Aim 3. Provide training and educational opportunities regarding small animal imaging technologies and approaches for members. During the previous award period, SAIL served members from three programs and contributed to 45 publications. In the most recent fiscal year, SAIL served 21 members, with 87% of total usage by peer-review- funded members. The SAIL uses a Laboratory Information Management System (LIMS) to consolidate usage tracking, scheduling, and billing functions. The LIMS also provides a secure repository for project and data management, which is accessible by members and their laboratory staff.

项目总结小动物成像实验室(SAIL)核心设施的目标是提供最先进的成像资源致莫菲特癌症中心(MCC)成员对啮齿动物癌症的基础和翻译临床前研究模特们。SAIL已经扩展了其服务范围，提供了广泛的多模式成像，包括磁共振成像，超极化MRI、CT、PET、SPECT、β粒子、超声、生物发光和荧光成像。这些系统允许成员跟踪肿瘤的发展、进展、转移和对在动物模型中使用定量成像进行治疗。SAIL提供了高空间分辨率的检测功能、代谢和解剖变化的数量，包括缺氧、酸碱度、对细胞的时间敏感性密度、血流、葡萄糖摄取和新陈代谢。这些参数可以使用SAIL的在图像特征提取和分析方面的专业知识，以生成对原位肿瘤生物学的综合分析。动物肿瘤模型对于理解癌症的生物学和不同肿瘤的复杂反应至关重要肿瘤类型的治疗。对这些动物对象的成像是一项可以准确定义癌症的核心技术行为。此外，由于SAIL提供的这些模式中的大多数都可在临床上使用，因此动物肿瘤模型可以很容易地转化为临床试验和临床实践。多模式成像是该设施的主要重点是提供广泛的技术，帮助成员在基本的和临床前研究项目。在下一个资助期，SAIL核心的具体目标是：目标1.协助成员进行实验设计、结果解释以及手稿和资助准备工作。目标2.提供和扩展体内和体外成像和分析技术，用于涉及以下方面的研究小动物癌症模型。目标3.提供有关小动物成像技术的培训和教育机会为成员提供的方法。在之前的颁奖期间，SAIL为三个项目的成员提供服务，并为45个项目做出贡献出版物。在最近一个财政年度，SAIL为21个成员提供服务，经同行审查，占总使用量的87%- 资助会员。SAIL使用实验室信息管理系统(LIMS)来巩固使用跟踪、调度和计费功能。LIMS还为项目和数据提供了安全的存储库管理，成员和他们的实验室工作人员可以访问。