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Small Animal Imaging Lab Core

小动物成像实验室核心

基本信息

批准号：
10115674
负责人：
David L Morse
金额：
$ 9.27万
依托单位：
H. LEE MOFFITT CANCER CTR & RES INST
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-02-18 至 2022-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10115674
关键词：
Anatomy Animal Cancer Model Animal Housing Animal Model Animal Technicians Animals Award Basic Science Behavior Beta Particle Bioluminescence Blood flow Cancer Biology Cancer Center Cancer Center Support Grant Cancer Model Clinic Clinical Trials Collaborations Complex Consultations Core Facility Detection Development Doctor of Philosophy Educational Activities Effectiveness Ensure Experimental Designs Florida Fluorescence Functional Imaging Funding Goals Grant Hand Hypoxia IACUC Image Imaging technology In Situ Individual Journals Laboratories Location Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Management Information Systems Manuscripts Metabolic Methodology Microscopy Modality Modeling Multimodal Imaging Mus Neoplasm Metastasis Nuclear Peer Review Photons Pilot Projects Positron-Emission Tomography Preparation Procedures Protocols documentation Publications Radiochemistry Reproducibility of Results Research Resolution Resources Rodent Roentgen Rays Scanning Schedule Scientist Secure Services System Technology Time Training Translating Tumor Biology Ultrasonography X-Ray Computed Tomography anatomic imaging animal care animal imaging animal resource bioluminescence imaging clinical practice data management density design ex vivo imaging experience feature extraction fluorescence imaging glucose metabolism glucose uptake imaging approach imaging capabilities imaging facilities imaging modality imaging study in vivo in vivo imaging instrument instrumentation intravital microscopy meetings member metabolic imaging microCT molecular imaging new technology novel strategies pre-clinical pre-clinical research preclinical study programs quality assurance quantitative imaging repository response serial imaging single photon emission computed tomography tumor ultrasound microscopy

项目摘要

PROJECT SUMMARY The goal of the Small Animal Imaging Lab (SAIL) Core Facility is to provide state-of-the art imaging resources to Moffitt Cancer Center (MCC) members for their basic and translational preclinical studies of rodent cancer models. The SAIL has expanded its services to offer a wide array of multimodality imaging, including MRI, hyperpolarized MRI, CT, PET, SPECT, beta particle, ultrasound, bioluminescence, and fluorescence imaging. These systems allow members to follow tumor development, progression, metastasis and the response to therapy in animal models using quantitative imaging. SAIL provides detection at high spatial resolution of a number of functional, metabolic and anatomical changes, including hypoxia, pH, temporal sensitivity to cellular density, blood flow, and glucose uptake and metabolism. These parameters can be quantified using SAIL's expertise in image feature extraction and analysis to generate an integrated analysis of tumor biology in situ. Animal tumor models are critical for understanding the biology of cancer and the complex responses of distinct tumor types to therapy. Imaging of these animal subjects is a core technology that can precisely define cancer behaviors. Further, as most of these modalities provided by the SAIL are available in the clinic, results with animal tumor models can be readily translated into clinical trials and clinical practice. Multimodality imaging is the key focus of the facility as this provides a broad range of technologies that assist members with their basic and pre-clinical research programs. Over the next funding period, the Specific Aims of the SAIL Core are to: Aim 1. Assist members in experimental design, interpretation of results, and manuscript and grant preparation. Aim 2. Provide and expand in vivo and ex vivo imaging and analytical technologies for research involving small animal cancer models. Aim 3. Provide training and educational opportunities regarding small animal imaging technologies and approaches for members. During the previous award period, SAIL served members from three programs and contributed to 45 publications. In the most recent fiscal year, SAIL served 21 members, with 87% of total usage by peer-review- funded members. The SAIL uses a Laboratory Information Management System (LIMS) to consolidate usage tracking, scheduling, and billing functions. The LIMS also provides a secure repository for project and data management, which is accessible by members and their laboratory staff.

项目总结