Small Animal Imaging Lab

小动物成像实验室

• 批准号: 10558787
• 负责人: David L Morse
• 金额: --
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-02-18 至 2027-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10558787
• 关键词: 3-Dimensional; 3D Print; Alpha Particles; Anatomy; Animal Cancer Model; Animal Model; Animals; Area; Basic Science; Behavior; Bioinformatics; Bioluminescence; Biostatistics Shared Resource; Blood Vessels; Blood flow; Brain Neoplasms; Budgets; Cancer Biology; Cancer Center; Cancer Center Support Grant; Cancer Model; Clinic; Clinical Trials; Collaborations; Complex; Computer software; Data; Data Analyses; Data Set; Detection; Development; Discipline of Nuclear Medicine; Educational workshop; Equipment; Experimental Designs; Faculty; Functional Imaging; Funding; Goals; Grant; Histology; Hypoxia; Image; Image Analysis; Imaging technology; Immune system; In Situ; Intranet; Journals; Magnetic Resonance Imaging; Malignant Neoplasms; Manuscripts; Metabolic; Metabolism; Metastatic malignant neoplasm to brain; Methods; Microscopy; Modality; Modeling; Multimodal Imaging; Neoplasm Metastasis; Optics; Organ; Pathogenesis; Peer Review; Physiology; Positioning Attribute; Positron-Emission Tomography; Preparation; Protocols documentation; Publications; Radiopharmaceuticals; Research; Research Design; Research Personnel; Resolution; Resources; Rodent; Roentgen Rays; Schedule; Science; Services; Spectrum Analysis; System; Technology; Time; Tissues; Training; Training and Education; Translating; Tumor Biology; Ultrasonography; Update; angiogenesis; animal imaging; beta particle imaging; bioluminescence imaging; cellular imaging; clinic ready; clinical practice; clinical trial implementation; co-clinical trial; data acquisition; data exchange; data sharing; density; design; ex vivo imaging; experimental study; feature extraction; fluorescence imaging; glucose metabolism; glucose uptake; imaging approach; imaging capabilities; imaging modality; in vivo; member; metabolic imaging; novel; nuclear imaging; photoacoustic imaging; pre-clinical; pre-clinical research; preclinical study; programs; quantitative imaging; response; single photon emission computed tomography; treatment response; tumor; ultrasound

PROJECT SUMMARY SMALL ANIMAL IMAGING LAB The overarching goal of the Small Animal Imaging Lab (SAIL) is to provide state-of-the art imaging resources to Moffitt Members for their basic and translational preclinical studies using rodent cancer models. SAIL offers a wide array of multimodality imaging capabilities (e.g., MRI, CT, SPECT, bioluminescence etc.) and provides pre- clinical radiopharmaceutical capabilities. Collectively, these technologies facilitate study of tumor development, progression, metastasis and the response to therapy in animal models using quantitative imaging. SAIL provides detection at high spatial resolution of functional, metabolic, and anatomical changes including hypoxia, pH, temporal sensitivity to cellular density, blood flow, and metabolism. A data transfer pipeline has been established where imaging data is transferred to QIC for image feature extraction and advanced image analysis to generate an integrated assessment of tumor biology in situ. SAIL activities are organized into three Specific Aims: Aim 1: To assist Members in experimental design, image data acquisition and analysis, and manuscript and grant preparation. Aim 2: To provide and expand cutting-edge in vivo and ex vivo imaging and analytical technologies for research involving small animal cancer models. Aim 3: To provide in-depth training and educational opportunities regarding small animal imaging technologies and approaches for Members. SAIL enables Members to perform sophisticated imaging experiments that support high impact science using preclinical animal models, which are critical for understanding the biology of cancer and the complex responses of distinct tumor types, the immune system and the physiology of the host to therapy. Small animal imaging informs future research design, can be used for the analysis of co-clinical trials, and also informs the design and implementation of clinical trials. Finally, as most of the modalities that are provided by SAIL are available in the clinic, results with animal tumor models can be readily translated into clinical trials and clinical practice. Since 2016, SAIL usage has increased by 15% and has supported 28 Member publications including 3 appearing in a high impact journal (IF >10). In FY20, SAIL supported 30 Members in four of the five Programs (CBE 33%, CE 3%, MM 27%, IO 37%) with 85% of those Members holding peer reviewed funding. This represented 93% of all SAIL usage. Over the next five years, SAIL will expand support for Members engaging in studies requiring in vivo metabolic and nuclear imaging through expansion of its services, equipment, and expert staff. This will position SAIL well to support the development of a metabolism focused CCSG Program and the many faculty who have research programs in this arena.

项目总结 小动物影像实验室 小动物成像实验室(SAIL)的首要目标是提供最先进的成像资源 Moffitt成员使用啮齿动物癌症模型进行基础和翻译临床前研究。赛尔提供了一种 多种多模式成像功能(例如，MRI、CT、SPECT、生物发光等)并提供预置的 临床放射药物能力。总的来说，这些技术促进了对肿瘤发展的研究， 应用定量成像技术在动物模型中研究进展、转移和治疗反应。赛尔提供了 以高空间分辨率检测功能、代谢和解剖变化，包括缺氧、pH、 对细胞密度、血流和新陈代谢的时间敏感性。已经建立了数据传输管道 将成像数据传输到QIC以进行图像特征提取和高级图像分析以生成 原位肿瘤生物学的综合评价。帆船活动分为三个具体目标： 目标1：协助成员进行实验设计、图像数据采集和分析、手稿和 格兰特准备。 目标2：为研究提供和扩展尖端的体内和体外成像和分析技术 涉及小动物癌症模型。 目标3：提供有关小动物成像技术的深入培训和教育机会 以及为成员提供的方法。 SAIL使成员能够执行复杂的成像实验，以支持高影响科学 临床前动物模型对了解癌症的生物学和复杂反应至关重要 不同的肿瘤类型，免疫系统和宿主的生理治疗。小动物成像 通知未来的研究设计，可用于联合临床试验的分析，还通知设计和 实施临床试验。最后，由于SAIL提供的大多数模式都可在 在临床上，动物肿瘤模型的结果可以很容易地转化为临床试验和临床实践。 自2016年以来，SAIL的使用量增加了15%，并支持了28个成员出版物，其中包括3个出现 发表在影响力较大的期刊上(如果&>10)。在2020财年，SAIL在五个计划中的四个计划中为30名成员提供了支持(CBE 33%， CE3%，MM 27%，IO 37%)，85%的成员持有同行评议基金。这一比例为93% 在所有风帆的使用中。在未来五年，SAIL将扩大对从事以下研究的成员的支持 通过扩大其服务、设备和专家人员，进行体内代谢和核成像。这将是 定位SAIL WELL以支持以新陈代谢为重点的CCSG项目和众多教职员工的发展 在这个领域有研究项目的人。