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Hippocampal neural dynamics driving affiliation and attachment

海马神经动力学驱动归属和依恋

基本信息

批准号：
10225059
负责人：
Zoe Rebecca Donaldson
金额：
$ 482.81万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10225059
关键词：
Adult Animals Architecture Automobile Driving Behavior Behavioral Brain region Cells Charge Chiroptera Complex Data Data Analyses Development Dimensions Disease Ecosystem Environment Fruit Future Generations Health Hippocampus (Brain)Hour Human Hypothalamic structure Image Imaging Device Intervention Investigation Mammals Memory Methodology Microscope Microtus Mus Neurobiology Neurons Oxytocin Partner in relationship Pathway interactions Pattern Personal Satisfaction Play Population Role Sensory Shapes Smell Perception Social Behavior Social Environment Social Interaction Social support System Techniques Technology Testing Time Vasopressins Wireless Technology affiliative behavior comparative data exchange design digital dyadic interaction experience in vivo calcium imaging insight miniaturize movie neural circuit neuronal patterning open source prairie vole relating to nervous system social social attachment social relationships technology development tool

项目摘要

Abstract: Attachment powerfully shapes our development and remains a primary driver of health and well-being in adulthood; disruption of attachments is highly traumatic. While affiliation, defined as general positive social interactions, is shared widely among mammals, attachment, or selective affiliation as a result of a bond, is far rarer and of primary relevance to humans. While affiliation has been studied in a number of contexts, how the neural circuitry that underlies affiliation ultimately contributes to adult attachment remains largely unknown. In this proposal, we will take a comparative framework to understand how the basic circuitry and neuronal patterns that underlie non-selective affiliation are ultimately engaged and underlie selective attachment in adulthood. Specifically, we will examine how the neurobiology of affiliative behavior in mice has been elaborated to support the more complex attachments formed by monogamous prairie voles and gregarious fruit bats, representing a spectrum of social relationships. We will focus on the hippocampal CA2 region as it has been shown to play a specialized role in social behavior and receives direct inputs from oxytocin and vasopressin producing cells in the paraventricular hypothalamus. Specifically, we will test the overarching hypothesis that CA2 population activity patterns follow similar trajectories across species before and during mating, and subsequently diverge to causally drive affiliative investigation in mice (Golshani/Hong) and different forms of attachment in prairie voles (Donaldson) and bats (Yartsev). To test this hypothesis we will refine and use new generation open-source wireless miniaturized microscopes (Aharoni) that will allow prolonged recordings of large neuronal populations in freely behaving animals. Kennedy will bring computational expertise and allow a unified data analysis framework cross species. In Aim 1 we will perform in-vivo calcium imaging in mice, prairie voles and bats to test the hypothesis that mating experiences modulate CA2 neural dynamics and that CA2 activity patterns encode spatial and identity information. We hypothesize that species that form attachments to mating partners, activity patterns will differentiate preferred vs. non-preferred partners. In Aim 2 we will use chemogenetic inhibition of CA2 in all species to determine whether CA2 causally drives affiliative and attachment behaviors. In Aim 3 we will test the hypothesis that inhibition of vasopressin inputs to CA2 will reduce the dimensionality of CA2 population activity patterns after mating, diminish memory of the mate in all species, and in voles and bats, reduce the decodability of the identity of the previous mating partner. In a technology development aim, we will develop and test a “true wireless” digital data transmitting microscope with power over distance charging capability that will allow prolonged imaging over many hours without human intervention.

文摘:

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Nucleus accumbens dopamine release reflects the selective nature of pair bonds.

伏隔核多巴胺的释放反映了成对键的选择性性质。

DOI：
10.1016/j.cub.2023.12.041
发表时间：
2024
期刊：
Current biology : CB
影响因子：
0
作者：
Pierce,AnneF;Protter,DavidSW;Watanabe,YurikaL;Chapel,GabrielD;Cameron,RyanT;Donaldson,ZoeR
通讯作者：
Donaldson,ZoeR

Neural basis of prosocial behavior.