Neuronal basis of social motivation and the failure to adapt to loss
社会动机的神经基础和无法适应损失
基本信息
- 批准号:9933419
- 负责人:
- 金额:$ 15.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAgeBehavioral ParadigmBereavementBiologicalBiological ProcessBrain regionCellsClinicalDistressEmotionalEmotionsExhibitsFailureFamily memberFriendsGrief reactionHealthHeart DiseasesHumanImageImpairmentIndividualInvestigationLearningLifeMental disordersMotivationNeuronsPainPair BondPartner in relationshipPathologicPopulationProcessPublic HealthRecoveryResearchRewardsSystemTestingTimeWorkbrain cellexperienceexperimental studyin vivoinsightloved onesmotivational processesneurogeneticsnovelprairie voleresponsesocialsocial attachmentsocial engagementtool
项目摘要
Project Summary
Social bonds between family members and friends can last a lifetime. As long as these attachments exist, the
selective motivation that drives us to seek out and interact with these individuals represents a healthy, reinforcing
mechanism that maintains these bonds. But what happens to these motivational systems when a bond is
permanently lost? Most people eventually learn to adapt to the loss of a loved one, but for some, the failure to
adapt leads to function-impairing grief that can last years. Clinically, this is known as complicated grief. Despite
the central importance of socio-motivational processes and their appropriate transformation following loss, their
neuronal basis remains unclear. To address this deficit, I propose to use monogamous prairie voles, which form
life-long bonds and exhibit distress following separation from their partner. Pair-bonded prairie voles will lever-
press to be reunited with their partner, enabling us to quantify bond-directed motivation. My lab is developing a
high-throughput operant system to quantify bond-directed motivation. I will combine this novel behavioral
paradigm with advanced neurogenetic tools to interrogate the neuronal substrates of bond-directed motivation.
I will test whether bond strength predicts levels of partner-directed motivation and how quickly this motivation
extinguishes following permanent partner separation. Then, using our operant paradigm in combination with in
vivo Ca2+ imaging and cell-specific manipulations of neuronal activity, I will test the hypothesis that distinct
neuronal populations within reward-related brain regions modulate partner-directed motivation. Finally, because
some people experience pathological forms of grief characterized by persistent dwelling on the lost bond, I will
ask whether artificially reactivating the neuronal ensemble that encodes a pair bond leads to prolonged
motivational responses following bond loss. Completion of these experiments will provide fundamental insights
into the engagement of social motivation systems at a neuronal level – both when a bond remains intact and
following its disruption. There is a pressing need for this research; there are no currently accepted paradigms for
studying selective social motivation or the emotional response to loss. As the U.S. population ages, there will be
a substantial public-health burden from increased rates of bereavement-induced mental illness, heart disease,
and complicated grief, and this work represents a means to elucidate important biological mechanisms that
contribute to these phenomena.
项目总结
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
How prior pair-bonding experience affects future bonding behavior in monogamous prairie voles.
- DOI:10.1016/j.yhbeh.2020.104847
- 发表时间:2020-11
- 期刊:
- 影响因子:3.5
- 作者:Harbert KJ;Pellegrini M;Gordon KM;Donaldson ZR
- 通讯作者:Donaldson ZR
PhAT: A flexible open-source GUI-driven toolkit for photometry analysis.
PhAT:一个灵活的开源 GUI 驱动工具包,用于光度分析。
- DOI:10.1101/2023.03.14.532489
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:Murphy,KathleenZ;Haile,Eyobel;McTigue,Anna;Pierce,AnneF;Donaldson,ZoeR
- 通讯作者:Donaldson,ZoeR
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Zoe Rebecca Donaldson其他文献
Zoe Rebecca Donaldson的其他文献
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{{ truncateString('Zoe Rebecca Donaldson', 18)}}的其他基金
Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony
动态纠缠:个体间神经同步的功能作用和机制基础
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10644475 - 财政年份:2023
- 资助金额:
$ 15.66万 - 项目类别:
The neuromolecular basis of adaptation to bond loss
适应键损失的神经分子基础
- 批准号:
10374344 - 财政年份:2022
- 资助金额:
$ 15.66万 - 项目类别:
The neuromolecular basis of adaptation to bond loss
适应键损失的神经分子基础
- 批准号:
10565940 - 财政年份:2022
- 资助金额:
$ 15.66万 - 项目类别:
Hippocampal neural dynamics driving affiliation and attachment
海马神经动力学驱动归属和依恋
- 批准号:
10225059 - 财政年份:2021
- 资助金额:
$ 15.66万 - 项目类别:
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血清素 1a 受体表达的变化是抑郁症风险的一个来源
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8618070 - 财政年份:2014
- 资助金额:
$ 15.66万 - 项目类别:
Variation in serotonin 1a receptor expression as a source of depression risk
血清素 1a 受体表达的变化是抑郁症风险的一个来源
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8851682 - 财政年份:2014
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Variation in serotonin 1a receptor expression as a source of depression risk
血清素 1a 受体表达的变化是抑郁症风险的一个来源
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9352881 - 财政年份:2014
- 资助金额:
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