Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony

动态纠缠：个体间神经同步的功能作用和机制基础

• 批准号: 10644475
• 负责人: Zoe Rebecca Donaldson
• 金额: $ 143.17万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10644475
• 关键词: Acute; Animals; Automobile Driving; Behavior; Behavioral; Biological; Brain; Cognitive; Complex; Data; Development; Devices; Dimensions; Distant; Dopamine; Dopamine Receptor; Engineering; Evaluation; Exhibits; Gender; Generations; Genetic; Head; Human; Image; Implant; Individual; Investigation; Laboratory mice; Life; Link; Medial; Mediating; Mental Health; Microtus; Molecular Genetics; Molecular Neurobiology; Monitor; Motion; Mus; Neuromodulator; Neurons; Optics; Oxytocin; Oxytocin Receptor; Pair Bond; Pattern; Pharmacology; Photometry; Photons; Population; Positioning Attribute; Prefrontal Cortex; Property; Resolution; Rodent; Role; Shapes; Signal Transduction; Social Behavior; Social Concepts; Social Functioning; Social Interaction; System; Technology; Testing; Thalamencephalon; Therapeutic; Visualization; Wireless Technology; Work; base; cell type; comparative; computational neuroscience; genetic approach; genetic manipulation; hippocampal pyramidal neuron; imaging approach; miniaturize; neglect; neural; neuromechanism; neuroregulation; novel; optogenetics; physical conditioning; prairie vole; preference; sensor; social; social attachment; social organization; technology development; tool; two-photon; wireless

PROJECT SUMMARY The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several levels of analysis. It remains unclear what aspects of social behavior are driven by these intriguing inter-brain dynamics. We propose to develop and apply a revolutionary set of molecular-genetic and optical tools to record and manipulate neural activity wirelessly and simultaneously in multiple interacting animals from distantly related rodent species across a broad spectrum of sociality. These studies include evaluation of synchrony parameters, along with causal imposition of synchrony to drive social behaviors and attachment. We aim to leverage novel functional genetic approaches to identify the cellular and subcellular basis and neuromodulatory mechanisms that underlie the emergence and strengthening of synchrony. This project will revolutionize our concept of the social brain, placing a multi-dimensional emphasis on neural activity within and across interacting brains, linked by the non-corporeal bonds of shared life. This is critical for understanding the full breadth of human sociality, identity, neurotypical and atypical behavior, as well as mental and physical health.

项目总结 脊椎动物的大脑已经进化为能够进行复杂的社会互动，这是生存所必需的。动物的大脑 参与共享社交活动的人表现出大脑间神经活动的同步性，在几个 分析水平。目前尚不清楚社会行为的哪些方面是由这些耐人寻味的大脑间质驱动的 动力学。我们计划开发和应用一套革命性的分子遗传学和光学工具来记录 并以无线方式同时操控来自远亲的多个互动动物的神经活动 在广泛的社会性范围内的啮齿动物种类。这些研究包括同步参数的评估， 随之而来的是对同步性的因果强加，以驱动社会行为和依恋。我们的目标是利用新奇 识别细胞和亚细胞基础和神经调节机制的功能遗传学方法 这是同步性出现和加强的基础。这个项目将彻底改变我们对 社交大脑，多维强调相互作用的大脑内部和之间的神经活动，链接 共享生活中的非物质纽带。这对于理解人类社会性的全部广度是至关重要的， 身份、神经典型和非典型行为，以及心理和身体健康。