Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony
动态纠缠:个体间神经同步的功能作用和机制基础
基本信息
- 批准号:10644475
- 负责人:
- 金额:$ 143.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-09-01 至 2026-08-31
- 项目状态:未结题
- 来源:
- 关键词:AcuteAnimalsAutomobile DrivingBehaviorBehavioralBiologicalBrainCognitiveComplexDataDevelopmentDevicesDimensionsDistantDopamineDopamine ReceptorEngineeringEvaluationExhibitsGenderGenerationsGeneticHeadHumanImageImplantIndividualInvestigationLaboratory miceLifeLinkMedialMediatingMental HealthMicrotusMolecular GeneticsMolecular NeurobiologyMonitorMotionMusNeuromodulatorNeuronsOpticsOxytocinOxytocin ReceptorPair BondPatternPharmacologyPhotometryPhotonsPopulationPositioning AttributePrefrontal CortexPropertyResolutionRodentRoleShapesSignal TransductionSocial BehaviorSocial ConceptsSocial FunctioningSocial InteractionSystemTechnologyTestingThalamencephalonTherapeuticVisualizationWireless TechnologyWorkbasecell typecomparativecomputational neurosciencegenetic approachgenetic manipulationhippocampal pyramidal neuronimaging approachminiaturizeneglectneuralneuromechanismneuroregulationnoveloptogeneticsphysical conditioningprairie volepreferencesensorsocialsocial attachmentsocial organizationtechnology developmenttooltwo-photonwireless
项目摘要
PROJECT SUMMARY
The vertebrate brain has evolved to enable complex social interactions, essential for survival. Brains of animals
engaged in a shared social interaction exhibit inter-brain synchronization of neural activity, detectable at several
levels of analysis. It remains unclear what aspects of social behavior are driven by these intriguing inter-brain
dynamics. We propose to develop and apply a revolutionary set of molecular-genetic and optical tools to record
and manipulate neural activity wirelessly and simultaneously in multiple interacting animals from distantly related
rodent species across a broad spectrum of sociality. These studies include evaluation of synchrony parameters,
along with causal imposition of synchrony to drive social behaviors and attachment. We aim to leverage novel
functional genetic approaches to identify the cellular and subcellular basis and neuromodulatory mechanisms
that underlie the emergence and strengthening of synchrony. This project will revolutionize our concept of the
social brain, placing a multi-dimensional emphasis on neural activity within and across interacting brains, linked
by the non-corporeal bonds of shared life. This is critical for understanding the full breadth of human sociality,
identity, neurotypical and atypical behavior, as well as mental and physical health.
项目摘要
脊椎动物的大脑已经进化到能够进行复杂的社会互动,这对生存至关重要。动物的大脑
参与共享的社会互动表现出神经活动的脑间同步,在几个
分析水平。目前还不清楚社会行为的哪些方面是由这些有趣的间脑驱动的
动力学我们建议开发和应用一套革命性的分子遗传和光学工具来记录
并通过无线方式同时操纵多个动物的神经活动,
啮齿类动物在社会性上的广泛差异这些研究包括同步参数的评估,
沿着因果强加的同步性来驱动社会行为和依恋。我们的目标是利用小说
功能遗传学方法,以确定细胞和亚细胞基础和神经调节机制
这是同步性出现和加强的基础。这个项目将彻底改变我们的概念
社会大脑,将多维度的重点放在相互作用的大脑内部和之间的神经活动上,
共同生活的非肉体纽带。这对于理解人类社会性的全部广度至关重要,
身份,神经典型和非典型行为,以及精神和身体健康。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Zoe Rebecca Donaldson其他文献
Zoe Rebecca Donaldson的其他文献
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{{ truncateString('Zoe Rebecca Donaldson', 18)}}的其他基金
The neuromolecular basis of adaptation to bond loss
适应键损失的神经分子基础
- 批准号:
10374344 - 财政年份:2022
- 资助金额:
$ 143.17万 - 项目类别:
The neuromolecular basis of adaptation to bond loss
适应键损失的神经分子基础
- 批准号:
10565940 - 财政年份:2022
- 资助金额:
$ 143.17万 - 项目类别:
Hippocampal neural dynamics driving affiliation and attachment
海马神经动力学驱动归属和依恋
- 批准号:
10225059 - 财政年份:2021
- 资助金额:
$ 143.17万 - 项目类别:
Neuronal basis of social motivation and the failure to adapt to loss
社会动机的神经基础和无法适应损失
- 批准号:
9933419 - 财政年份:2018
- 资助金额:
$ 143.17万 - 项目类别:
Variation in serotonin 1a receptor expression as a source of depression risk
血清素 1a 受体表达的变化是抑郁症风险的一个来源
- 批准号:
8618070 - 财政年份:2014
- 资助金额:
$ 143.17万 - 项目类别:
Variation in serotonin 1a receptor expression as a source of depression risk
血清素 1a 受体表达的变化是抑郁症风险的一个来源
- 批准号:
8851682 - 财政年份:2014
- 资助金额:
$ 143.17万 - 项目类别:
Variation in serotonin 1a receptor expression as a source of depression risk
血清素 1a 受体表达的变化是抑郁症风险的一个来源
- 批准号:
9352881 - 财政年份:2014
- 资助金额:
$ 143.17万 - 项目类别:
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