Project C: Neural basis of causal inference in continuous navigation

项目 C:连续导航中因​​果推理的神经基础

基本信息

  • 批准号:
    10225405
  • 负责人:
  • 金额:
    $ 89.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-08-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary When sensory inputs are ambiguous, the brain builds an internal model to infer which events in the world caused this pattern of sensory activity. This process, called causal inference, provides a unifying framework for understanding how neural signals that represent beliefs about the structure of the world interact with incoming sensory signals to drive perception-action loops. This proposal focuses on perceptual interactions among object motion, object depth, and an animal's self-motion through the world, as a particular moving pattern of neural activity on the retina can be generated by many combinations of object motion in the world and self- motion. The overall hypothesis is that parietal and prefrontal neurons infer whether an object moves in the world, and that these signals flow through feedback projections to update task-relevant representations in extrastriate visual cortex. The goal of this project is to study causal inference in dynamic tasks, in which an animal's internal model of the world changes continuously. In a virtual reality navigation task in monkeys and mice, these experiments will explore brain computation and multi-area interactions in the naturalistic setting of continuous action and active sensing, as well as dynamic on-line inference about latent, task-relevant variables related to the internal model. This project will develop a causal inference version of a dynamic navigation task already in use in the Angelaki laboratory and then use population recordings and causal neural manipulations to test and refine the dynamic model developed by the theory team in Project A. The continuous-time latent variables of this model will be fitted to monkey and mouse behavioral data to reveal each animal's beliefs about the state of the world and interacting task-relevant variables, and to generate novel hypotheses about the neural dynamics. Using multi-electrode recordings and chemical and optogenetic manipulations, this project will test these hypotheses in four mutually interconnected monkey brain areas involved in visual perception, navigation, memory, and decision-making: parietal area 7a, prefrontal area 8aV, and extrastriate visual cortical areas MSTd (dorsal medial superior temporal) and MT (middle temporal). Finally, neural activity will be mapped throughout the mouse brain, with an emphasis on subcortical structures, using parallel recordings with Neuropixels probes for hypothesis-free identification of other areas that are modulated by this dynamic task, which will also serve to generalize the findings across species. Based on these findings, additional macaque brain regions will be targeted for recording and manipulation experiments as needed. Collectively, these experiments will rigorously test the computational framework of dynamic causal inference across species and brain areas. When compared with the complementary findings from trial-based tasks in Project B, successful completion of these experiments is expected to uncover general principles of the function of causal inference processes and top-down feedback connections during naturalistic and dynamically fluid behavior.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Dora Angelaki其他文献

Dora Angelaki的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Dora Angelaki', 18)}}的其他基金

Computational dynamics in neural populations of freely foraging vs. restrained monkeys
自由觅食与受限制猴子神经群体的计算动力学
  • 批准号:
    10447347
  • 财政年份:
    2022
  • 资助金额:
    $ 89.85万
  • 项目类别:
Project C: Neural basis of causal inference in continuous navigation
项目 C:连续导航中因​​果推理的神经基础
  • 批准号:
    10615056
  • 财政年份:
    2020
  • 资助金额:
    $ 89.85万
  • 项目类别:
Project C: Neural basis of causal inference in continuous navigation
项目 C:连续导航中因​​果推理的神经基础
  • 批准号:
    10400148
  • 财政年份:
    2020
  • 资助金额:
    $ 89.85万
  • 项目类别:
Plasticity during visual/vestibular conflict
视觉/前庭冲突期间的可塑性
  • 批准号:
    9825191
  • 财政年份:
    2018
  • 资助金额:
    $ 89.85万
  • 项目类别:
Using gravity to perceive, move and orient
利用重力来感知、移动和定向
  • 批准号:
    10523529
  • 财政年份:
    2018
  • 资助金额:
    $ 89.85万
  • 项目类别:
Using gravity to perceive, move and orient
利用重力来感知、移动和定向
  • 批准号:
    10330565
  • 财政年份:
    2018
  • 资助金额:
    $ 89.85万
  • 项目类别:
Plasticity during visual/vestibular conflict
视觉/前庭冲突期间的可塑性
  • 批准号:
    9757745
  • 财政年份:
    2018
  • 资助金额:
    $ 89.85万
  • 项目类别:
Using gravity to perceive, move and orient
利用重力来感知、移动和定向
  • 批准号:
    10056192
  • 财政年份:
    2018
  • 资助金额:
    $ 89.85万
  • 项目类别:
Plasticity during visual/vestibular conflict
视觉/前庭冲突期间的可塑性
  • 批准号:
    9099291
  • 财政年份:
    2016
  • 资助金额:
    $ 89.85万
  • 项目类别:
Inertial and multisensory influences on entorhinal grid cells
惯性和多感官对内嗅网格细胞的影响
  • 批准号:
    9163935
  • 财政年份:
    2016
  • 资助金额:
    $ 89.85万
  • 项目类别:

相似海外基金

The earliest exploration of land by animals: from trace fossils to numerical analyses
动物对陆地的最早探索:从痕迹化石到数值分析
  • 批准号:
    EP/Z000920/1
  • 财政年份:
    2025
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Fellowship
Animals and geopolitics in South Asian borderlands
南亚边境地区的动物和地缘政治
  • 批准号:
    FT230100276
  • 财政年份:
    2024
  • 资助金额:
    $ 89.85万
  • 项目类别:
    ARC Future Fellowships
The function of the RNA methylome in animals
RNA甲基化组在动物中的功能
  • 批准号:
    MR/X024261/1
  • 财政年份:
    2024
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Fellowship
Ecological and phylogenomic insights into infectious diseases in animals
对动物传染病的生态学和系统发育学见解
  • 批准号:
    DE240100388
  • 财政年份:
    2024
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Discovery Early Career Researcher Award
Zootropolis: Multi-species archaeological, ecological and historical approaches to animals in Medieval urban Scotland
Zootropolis:苏格兰中世纪城市动物的多物种考古、生态和历史方法
  • 批准号:
    2889694
  • 财政年份:
    2023
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Studentship
Using novel modelling approaches to investigate the evolution of symmetry in early animals.
使用新颖的建模方法来研究早期动物的对称性进化。
  • 批准号:
    2842926
  • 财政年份:
    2023
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Studentship
Study of human late fetal lung tissue and 3D in vitro organoids to replace and reduce animals in lung developmental research
研究人类晚期胎儿肺组织和 3D 体外类器官在肺发育研究中替代和减少动物
  • 批准号:
    NC/X001644/1
  • 财政年份:
    2023
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Training Grant
RUI: Unilateral Lasing in Underwater Animals
RUI:水下动物的单侧激光攻击
  • 批准号:
    2337595
  • 财政年份:
    2023
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Continuing Grant
RUI:OSIB:The effects of high disease risk on uninfected animals
RUI:OSIB:高疾病风险对未感染动物的影响
  • 批准号:
    2232190
  • 财政年份:
    2023
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Continuing Grant
A method for identifying taxonomy of plants and animals in metagenomic samples
一种识别宏基因组样本中植物和动物分类的方法
  • 批准号:
    23K17514
  • 财政年份:
    2023
  • 资助金额:
    $ 89.85万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了