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UCLA IDDRC

加州大学洛杉矶分校国际数据研究中心

基本信息

批准号：
10224907
负责人：
SUSAN Y BOOKHEIMER
金额：
$ 124.16万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10224907
关键词：
3-Dimensional Accountability Advocacy Animal Behavior Animal Model Animals Basic Science Bioinformatics Biological Models Biometry Brain Cells Clinical Clinical Trials Clinical Trials Design Cognition Collaborations Collection Communication Communities Community Outreach Consultations Core Facility D Cells Databases Development Diagnosis Discipline Education Education and Outreach Educational workshop Electrophysiology (science)Environment Epigenetic Process Equipment and supply inventories Faculty Family Fostering Functional Imaging Functional Magnetic Resonance Imaging Funding Gene Expression Genetic Genomics Genotype Goals Grant Group Meetings Health Fairs Human Image Impaired cognition In Vitro Individual Infrastructure Institutes Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study Intervention Lead Longevity Methods Microscopy Minority Mission Modeling Organoids Parents Patients Personal Satisfaction Phenotype Request for Applications Request for Proposals Research Research Personnel Research Project Grants Research Proposals Research Support Resources Rett Syndrome Schools Science Scientist Series Services Sleep Sleep disturbances Slow-Wave Sleep Special Event Spectrum Analysis Structure Syndrome System Systems Analysis Technology Training Translating Translational Research Universities Visit Visualization Washington behavioral phenotyping clinical translation community center community partnership data management data sharing design developmental neurobiology effective therapy experimental study financial incentive genetic analysis genomic data improved in vivo induced pluripotent stem cell innovation innovative technologies interdisciplinary approach interdisciplinary collaboration lectures meetings model development multidisciplinary neurodevelopment new technology novel optogenetics outreach program dissemination recruit sleep abnormalities sleep physiology symposium tool voucher working group

项目摘要

This proposal requests 5 years of additional funding for the UCLA Intellectual and Developmental Disabilities Research Center (IDDRC). For over 40 years, our mission has been to provide an optimal environment for conducting multidisciplinary research into the mechanisms underlying intellectual and developmental disabilities (IDDs), to translate these findings into effective treatments for IDDs, and disseminate these findings to the scientific community and the public. This submission expands on the translational focus that we began 5 years ago with an added emphasis on human research and clinical trials, and closer ties to the community. Each of the 5 cores are structured to facilitate interdisciplinary collaborations, following four thematic goals: 1) providing state of the art infrastructure for IDD related research; 2) encourage innovation by supporting technical development and providing financial incentives for new projects; 3) promote integration across disciplines, by encouraging interdisciplinary research among faculty and between cores; and 4) to disseminate advances in technology to other scientists, train new IDD investigators, and convey findings to the scientific community and stakeholders in community outreach efforts. We propose 5 interacting cores: A: Administration and Dissemination, which oversees core functions and usage, assures quality and accountability, and promotes outreach and dissemination; B: Clinical Translation, supporting clinical trials, recruitment, diagnosis and deep phenotyping, and biosample collection; C: Genetics, Genomics and BioInformatics, which performs genetic analysis, sequencing, expression, and provides resources for planning and executing analysis of genomics data; D: Cells, Circuits and Systems, supporting human iPSC and 3-dimensional organoid development, in- and ex- vivo electrophysiology and optogenetics; and E: Structural and Functional Visualization, which provides training, access, and analysis services for in vitro microscopy, mini-cameras for in vivo visualization, animal and human structural and functional MRI and spectroscopy. Our model research project focuses on mechanisms underlying sleep impairments in two IDDs, building on new findings from our last submission: a near absence of slow-wave sleep in Dup15q syndrome. We will examine mechanisms underlying sleep impairments in Dup15q and Rett's Syndrome using a multidisciplinary approach that includes a clinical component, animal models, and brain organoid model using patient-derived IPSCs, to elucidate how mechanisms underlying altered sleep physiology lead to cognitive dysfunction. Results from this project will directly inform next steps for developing interventions that may modulate sleep and, in turn, neurodevelopment in IDDs.

该提案要求为加州大学洛杉矶分校智力和发育障碍研究中心提供5年的额外资金