Administrative Core

行政核心

• 批准号: 10227134
• 负责人: Gary Allen Rosenberg
• 金额: $ 28.97万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227134
• 关键词: Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; American Indians; Area; Basic Science; Biological Markers; Blood; Blood Vessels; Budgets; Caring; Chairperson; Clinical; Cognitive; Collaborations; Communication; Communities; Community Health; Consent; Data; Data Set; Databases; Dementia; Diagnosis; Elderly; Ensure; Event; Faculty; Funding; Funding Mechanisms; Geriatrics; Goals; Government Officials; Grant; Guidelines; Head; Health Occupations; Human; Image; Image Analysis; Imaging Device; Incidence; Inflammation; Information Systems; Infrastructure; Link; Magnetic Resonance Imaging; Memory; Mentorship; Methods; Mind-Body Method; Minority Groups; Molecular; Neurology; Neuropsychology; Neurosciences; New Mexico; Newsletter; Patient Recruitments; Physicians; Pilot Projects; Population; Prevalence; Procedures; Process; Pueblo Race; Research; Research Personnel; Research Project Grants; Resources; Role; Rural Population; Science; Scientist; Senior Scientist; Services; Site; State Government; Students; Testing; Textbooks; Time; Tissue Sample; Training; Translational Research; Trust; Underrepresented Minority; United States National Institutes of Health; Universities; Vascular Diseases; Work; Zuni; advocacy organizations; clinical practice; community organizations; data submission; early-career faculty; experience; health care service; innovation; insight; interest; medical schools; meetings; member; neuroimaging; next generation; outreach; programs; quality assurance; ranpirnase; rural Americans; screening; service providers; social media; tau Proteins; training opportunity; transmission process; undergraduate student; urban Native American; vaccine development; vascular factor; web site

Abstract Administrative Core: The Administrative Core (AC) of New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC) is critical for the management of the center by convening committees and interacting with NACC, NCRAD, and NIA. NM eADRC creates an infrastructure for AD science in New Mexico, raising the level of research participation in rural American Indian (AI) communities, and increasing the understanding of the role of vascular disease in AD and related dementias (AD/ADRD) through the use of biomarkers and advances in neuroimaging. The AC will ensure the successful completion of the aims in the Overall, Clinical and Scientific Cores. The AC will form committees to help achieve the goals of the NM eADRC. The AC will link senior scientists with junior faculty, trainees, clinical practice physicians and community health representatives (CHRs). The scientists in the NM eADRC are accomplished investigators with extensive experience managing large research projects, training junior investigators, and working as a team. The PI was head of Neurology at UNM and is director of the Center for Memory and Aging. As Chair, he managed two neuroscience CoBRE grants. The Co-Director of the NM eADRC is a nationally recognized researcher in AD and a leader in the development of a vaccine against tau protein. The AC Co-Leader is trained in geriatrics and neurology, co-edited the textbook on geriatric neurology and has engaged with local communities and state-wide organizations for many years in dementia related activities. Neuropsychology will be directed by Drs. Sadek and Prestopnik and neuroimaging by Drs. Caprihan and Kiehl. A demonstration/pilot project will use community health representatives and mobile MR imaging to bring AD research to the tribal areas with the Mobile On-Site Screening and Testing (MOSST), using the two mobile 1.5T MRI scanners at the MIND Research Network. The innovative work on developing vascular biomarkers will add a vascular component to the NIA-AA criterial for AD. BBB studies developed at UNM will provide insight into mechanisms of inflammation. A major advantage of the NM eADRC is the ability to include data from underrepresented minorities in the NACC, ADNI, and NCRAD databases. The NM eADRC will bring to the southwest a major center for research and innovative care in AD/ADRD that will utilize the outstanding scientific resources in the state, while building a greater understanding of the needs of rural and minority populations.

抽象管理核心： 新墨西哥州探索性阿尔茨海默病研究中心行政核心(AC) EADRC)对中心的管理至关重要，它通过召集委员会和与 NACC、NCRAD和NIA。NM eADRC在新墨西哥州为AD科学创建基础设施，提高 美国印第安人(AI)农村社区的研究参与水平，并增加 血管疾病在AD及相关痴呆(AD/ADRD)中的作用 生物标志物和神经成像的进展。咨询委员会将确保圆满完成目标 总体而言，临床和科学核心。咨询委员会将成立委员会，以帮助实现 NM eADRC。AC将把高级科学家与初级教员、实习生、临床实践医生和 社区卫生代表(CHR)。NM eADRC的科学家们已经完成了 具有管理大型研究项目、培训初级调查人员的丰富经验的调查人员， 像一个团队一样工作。PI曾任UNM神经科主任，现为记忆中心主任 和老龄化。作为主席，他管理着两笔神经科学科布雷奖学金。NM eADRC联席主任 是国家公认的AD研究人员，也是开发tau疫苗的领先者 蛋白。AC联合领导接受过老年病学和神经病学方面的培训，共同编辑了关于老年病学的教科书 神经科，多年来一直与当地社区和全州组织接触 痴呆症相关活动。神经心理学将由Sadek和Prestopnik博士指导， 卡普里汉博士和基尔博士的神经成像。一个示范/试点项目将利用社区卫生 代表和移动磁共振成像通过Mobile现场将AD研究带到部落地区 使用Mind Research的两台移动式1.5T磁共振扫描仪进行筛查和测试(MOSST) 网络。开发血管生物标记物的创新工作将为 NIA-AA诊断AD的标准。在UNM开展的BBB研究将提供对以下机制的见解 发炎。NM eADRC的一个主要优势是能够包括来自代表性不足的数据 NACC、ADNI和NCRAD数据库中的少数民族。NM eADRC将为西南部带来一个 AD/ADRD的主要研究和创新护理中心，将利用杰出的科学 国家资源，同时更好地了解农村和少数民族的需求 人口。