New Mexico Alzheimer's Disease Research Center

新墨西哥州阿尔茨海默病研究中心

• 批准号: 10227133
• 负责人: Gary Allen Rosenberg
• 金额: $ 103.07万
• 依托单位: UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227133
• 关键词: Address; Aging; Alzheimer' s Disease; Alzheimer' s disease diagnosis; Alzheimer' s disease related dementia; American Indians; Amyloid; Area; Autopsy; Awareness; BRAIN initiative; Basic Science; Biological; Biological Markers; Blood - brain barrier anatomy; Blood Vessels; Caring; Clinic; Clinical; Clinical Services; Cognition; Cognitive; Collaborations; Communities; Community Health; Complement; Data; Data Set; Databases; Dementia; Diffusion Magnetic Resonance Imaging; Disease; Education; Educational Background; Educational Status; Elderly; Faculty; Feedback; Functional disorder; Funding; Geriatrics; Goals; Grant; Image; Imaging Device; Impaired cognition; Incidence; Inflammation; Infrastructure; Injury; Lewy Body Dementia; Liquid substance; Low income; MRI Scans; Magnetic Resonance Imaging; Measures; Medical center; Memory; Minority; Mission; Movement Disorders; Nerve Degeneration; Neuropsychological Tests; New Mexico; Nursing Faculty; Outcome; Parkinson' s Dementia; Participant; Patient Recruitments; Patients; Population; Population Heterogeneity; Population Study; Poverty; Prevalence; Prevention; Process; Pueblo Race; Research; Research Personnel; Resources; Rewards; Risk; Role; Rural; Rural Community; Rural Population; Sampling; Scientist; Services; Site; Socioeconomic Status; Specialist; Structure; System; Testing; Training; Travel; Tribal Elders; Tribes; Universities; Vascular Diseases; Work; Zuni; base; blood-brain barrier permeabilization; cognitive function; cognitive testing; comorbidity; contrast enhanced; cost effective; data repository; dementia care; education research; gray matter; health disparity; high risk; improved; interest; magnetic resonance imaging biomarker; medical schools; member; mixed dementia; multimodality; neuropathology; non-genetic; novel; outreach; patient engagement; patient population; patient stratification; precision medicine; programs; ranpirnase; recruit; remote location; response; rural Americans; screening; synergism; tau Proteins; tribal community; vascular cognitive impairment and dementia; vascular factor; vascular inflammation; vascular risk factor; white matter

ABSTRACT (Overall Core) This proposal is to establish in New Mexico an exploratory Alzheimer's Disease Research Center (NM eADRC). The Center goals are: 1) to build infrastructure and hire faculty to enhance Alzheimer's disease (AD) research; 2) to meet the needs of rural communities with health disparities, and 3) to use multimodal biomarkers, including CSF and MRI, to incorporate vascular disease into the new NIA-AA Alzheimer's disease (AD) biological definition, improving patient stratefication. This P20 NM eADRC will build toward the P30 ADRC. We plan to hire new faculty with expertise in Alzheimer's disease (AD) and related dementias (RD). Infrastructure needs for care of the elderly will be met by the construction of new 7 million dollar building that will house three centers: Movement disorders, Geriatrics, and Center for Memory and Aging, creating synergy in care of the elderly. The NM eADRC will address the unmet needs in dementia care related to disparities, particularly in the large American Indian (AI) population. There are challenges to improving dementia care to AI that include cultural insensitivity, low income and educational levels, and long distances to travel for specialist care. We will overcome these barriers by using community health representatives to perform cognitive screening and a program for mobile on-site screening and testing (MOSST) that includes neuropsychological testing and mobile 1.5T MRI for imaging. This will fill a gap in the national AD databases for data on minorities. Vascular disease is a major co-morbidity with AD that accelerates the cognitive decline. It is estimated that up to 70% of nongenetic AD is mixed dementia (MX), making this an important group to identify prior to autopsy. We have developed biomarkers that can successfully stratify patients. This involves the use of CSF and MRI studies, and allows for the addition of the vascular feature (V) to the amyloid (A), tau (T), and neurodegeneration (N) components of the NIA-AA formula for diagnosis of AD. Biomarkers in the CSF have been identified by the MarkVCID consortium that indicate inflammation, which occurs when both AD and vascular disease are present. The NM eADRC will measure these unique biomarkers in the newly recruited participants, and provide these services to other ADRCs that are interested. The blood- brain barrier (BBB) has been implicated in the pathophysiology of AD. We plan to measure BBB permeability in gray and white matter in patients with AD and RD along with VCID and MX to better understand its role in dementia. The NM eADRC will be nidus for AD research to a large community of researchers around the state and will be major center within the Medical School Administrative structure. With the ability to bring in new faculty, build new buildings, and bring together the community of scientists interested in dementia in NM, it will make a huge impact that will provide the infrastructure for a successful P30 Center application.

摘要（总体核心） 该提案是在新墨西哥州建立一个探索性阿尔茨海默病研究中心（NM 电子防灾研究中心）。该中心的目标是：1）建设基础设施并聘请教职人员以改善阿尔茨海默病 (AD) 研究； 2) 满足存在健康差距的农村社区的需求，以及 3) 使用 多模式生物标志物，包括 CSF 和 MRI，将血管疾病纳入新的 NIA-AA 阿尔茨海默病 (AD) 的生物学定义，改善患者分层。此 P20 NM eADRC 将 朝着 P30 ADRC 的方向努力。我们计划聘请具有阿尔茨海默病（AD）和 相关痴呆症（RD）。通过建设新的基础设施来满足老年人护理的基础设施需求 耗资 700 万美元的大楼将容纳三个中心：运动障碍中心、老年病学中心和康复中心 记忆与衰老，协同照顾老年人。 NM eADRC 将解决未满足的问题 痴呆症护理的需求与差异有关，特别是在大量的美洲印第安人 (AI) 人口中。 改善人工智能的痴呆症护理面临挑战，包括文化不敏感、低收入和 教育水平以及长途旅行以获得专家护理。我们将克服这些障碍 使用社区健康代表进行认知筛查和现场移动程序 筛查和测试 (MOSST)，包括神经心理学测试和移动 1.5T MRI 成像。这将填补国家 AD 数据库中少数民族数据的空白。血管疾病是一种 与 AD 的主要共病会加速认知能力下降。据估计，高达 70% 非遗传性 AD 是混合性痴呆 (MX)，使其成为尸检前需要识别的重要群体。我们 已经开发出可以成功对患者进行分层的生物标志物。这涉及到脑脊液和 MRI 的使用 研究，并允许将血管特征 (V) 添加到淀粉样蛋白 (A)、tau (T) 和 用于诊断 AD 的 NIA-AA 公式的神经变性 (N) 成分。脑脊液中的生物标志物 MarkVCID 联盟已确定表明炎症，当两者 存在 AD 和血管疾病。 NM eADRC 将测量这些独特的生物标志物 新招募的参与者，并向其他感兴趣的 ADRC 提供这些服务。血—— 脑屏障（BBB）与 AD 的病理生理学有关。我们计划测量 BBB AD 和 RD 患者灰质和白质的通透性以及 VCID 和 MX 可以更好地 了解它在痴呆症中的作用。 NM eADRC 将成为大型社区 AD 研究的核心 州内的研究人员，并将成为医学院管理结构的主要中心。 有能力引进新教师、建造新建筑并将科学家群体聚集在一起 对新墨西哥州的痴呆症感兴趣，它将产生巨大的影响，为 P30中心申请成功。