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Administrative Core

行政核心

基本信息

批准号：
10450034
负责人：
Gary Allen Rosenberg
金额：
$ 36.92万
依托单位：
UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10450034
关键词：
Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia American Indians Area Basic Science Biological Markers Blood Blood Vessels Budgets Caring Chairperson Clinical Cognitive Collaborations Communication Communities Community Health Consent Data Data Set Databases Dementia Diagnosis Elderly Ensure Event Faculty Funding Funding Mechanisms Geriatrics Goals Government Officials Grant Guidelines Head Health Occupations Human Image Image Analysis Imaging Device Incidence Inflammation Information Systems Infrastructure Link Magnetic Resonance Imaging Memory Mentorship Methods Mind-Body Method Minority Groups Molecular Neurology Neuropsychology Neurosciences New Mexico Newsletter Patient Recruitments Physicians Pilot Projects Population Prevalence Procedures Process Pueblo Race Research Research Personnel Research Project Grants Resources Role Rural Population Science Scientist Senior Scientist Services Site State Government Students Testing Textbooks Time Tissue Sample Training Translational Research Trust Underrepresented Minority United States National Institutes of Health Universities Vascular Diseases Work Zuni advocacy organizations clinical practice community organizations data submission early-career faculty experience health care service innovation insight interest medical schools meetings member neuroimaging next generation outreach programs quality assurance ranpirnase rural Americans screening service providers social media tau Proteins training opportunity transmission process undergraduate student urban Native American vaccine development vascular factor web site

项目摘要

Abstract Administrative Core: The Administrative Core (AC) of New Mexico Exploratory Alzheimer’s Disease Research Center (NM eADRC) is critical for the management of the center by convening committees and interacting with NACC, NCRAD, and NIA. NM eADRC creates an infrastructure for AD science in New Mexico, raising the level of research participation in rural American Indian (AI) communities, and increasing the understanding of the role of vascular disease in AD and related dementias (AD/ADRD) through the use of biomarkers and advances in neuroimaging. The AC will ensure the successful completion of the aims in the Overall, Clinical and Scientific Cores. The AC will form committees to help achieve the goals of the NM eADRC. The AC will link senior scientists with junior faculty, trainees, clinical practice physicians and community health representatives (CHRs). The scientists in the NM eADRC are accomplished investigators with extensive experience managing large research projects, training junior investigators, and working as a team. The PI was head of Neurology at UNM and is director of the Center for Memory and Aging. As Chair, he managed two neuroscience CoBRE grants. The Co-Director of the NM eADRC is a nationally recognized researcher in AD and a leader in the development of a vaccine against tau protein. The AC Co-Leader is trained in geriatrics and neurology, co-edited the textbook on geriatric neurology and has engaged with local communities and state-wide organizations for many years in dementia related activities. Neuropsychology will be directed by Drs. Sadek and Prestopnik and neuroimaging by Drs. Caprihan and Kiehl. A demonstration/pilot project will use community health representatives and mobile MR imaging to bring AD research to the tribal areas with the Mobile On-Site Screening and Testing (MOSST), using the two mobile 1.5T MRI scanners at the MIND Research Network. The innovative work on developing vascular biomarkers will add a vascular component to the NIA-AA criterial for AD. BBB studies developed at UNM will provide insight into mechanisms of inflammation. A major advantage of the NM eADRC is the ability to include data from underrepresented minorities in the NACC, ADNI, and NCRAD databases. The NM eADRC will bring to the southwest a major center for research and innovative care in AD/ADRD that will utilize the outstanding scientific resources in the state, while building a greater understanding of the needs of rural and minority populations.

摘要管理核心：新墨西哥州探索性阿尔茨海默病研究中心（NM）行政核心（AC eADRC）通过召集委员会并与 NACC、NCRAD和NIA。NM eADRC为新墨西哥州的AD科学创建了一个基础设施，农村美国印第安人（AI）社区的研究参与水平，并增加了解血管疾病在AD和相关痴呆（AD/ADRD）中的作用，生物标志物和神经影像学的进展。咨询委员会将确保成功完成目标总体、临床和科学核心。咨询委员会将成立委员会，以帮助实现 NM eADRC。AC将把高级科学家与初级教师、实习生、临床实践医生和社区卫生代表。NM eADRC的科学家们具有丰富经验的研究人员管理大型研究项目，培训初级研究人员，和团队合作PI是UNM神经病学的负责人，也是记忆中心的主任和老化。作为主席，他管理了两项神经科学Cobre赠款。NM eADRC联合主任是全国公认的AD研究人员，也是开发tau疫苗的领导者。蛋白AC共同领导人接受过老年病学和神经病学培训，共同编辑了老年病学教科书，神经病学，并已与当地社区和全州组织多年来，痴呆症相关活动神经心理学将由Sadek和Prestopnik博士指导，卡普里汉和基尔博士的神经成像一个示范/试点项目将利用社区卫生代表和移动的MR成像，将AD研究带到部落地区，并配备移动的现场筛选和测试（MOSST），使用MIND Research的两台移动的1.5 T MRI扫描仪网络开发血管生物标志物的创新性工作将为血管生物标志物添加血管成分。 AD的NIA-AA标准。新墨西哥大学开展的BBB研究将为深入了解炎症NM eADRC的一个主要优势是能够包括来自代表性不足的数据少数民族在NACC，ADNI和NCRAD数据库。NM eADRC将为西南部带来一个 AD/ADRD研究和创新护理的主要中心，将利用杰出的科学国家资源，同时更好地了解农村和少数民族的需求，人口。