Enhancing Partner Services among Men Who Have Sex with Men Living With HIV: A Pilot Randomized Controlled Trial

加强男男性行为艾滋病毒感染者的伴侣服务：一项试点随机对照试验

• 批准号: 10227179
• 负责人: Weiming Tang
• 金额: $ 18.67万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-08 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10227179
• 关键词: AIDS prevention; Address; Caring; Cellular Phone; China; Chinese People; Cities; Cohort Studies; Communities; Community Participation; Computers; Cost Savings; Country; Data; Disease; Disease Outbreaks; Effectiveness; Effectiveness of Interventions; Entrepreneurship; Environment; Exposure to; Female; HIV; Health; Health Personnel; Human immunodeficiency virus test; Image; Incidence; Income; Individual; Infection; Infrastructure; Interdisciplinary Study; Internet; Intervention; Investments; Lead; Link; Methods; Monitor; Notification; Participant; Patients; Persons; Phase; Pilot Projects; Population; Prevalence; Prevention strategy; Process; Public Health; Randomized; Randomized Controlled Trials; Recording of previous events; Reporting; Research; Research Personnel; Research Training; Resources; Risk; Series; Services; Sexual Health; Sexual Partners; Specialist; Spouses; System; Testing; Voice; acceptability and feasibility; arm; base; community based participatory research; comparison group; condoms; cost; cost effectiveness; crowdsourcing; design; efficacy evaluation; experience; feasibility testing; group intervention; hackathon; health disparity; improved; indexing; infection rate; innovation; low and middle-income countries; male; member; men who have sex with men; public health relevance; service intervention; social; standard of care; study population; success; testing uptake; theories; therapy development; tool; transmission process; treatment arm

Project title: Enhancing Partner Services among Men Who Have Sex with Men Living With HIV: A Pilot Randomized Controlled Trial Despite global efforts to control HIV among key populations, new infections among men who have sex with men (MSM) are still increasing. To deal with this challenge, HIV prevention strategies with high efficacy are urgently needed. Partner services (PS), the process of informing potential risk of exposure to sexual partners, is a cornerstone of HIV prevention. PS are important for identifying cases, reducing re-infection rates, promoting linkage to care, and reducing costs. However, barriers from both health providers and index cases limit the efficacy of PS. As a result, PS is underused in many countries, including China where only 16% of index HIV case spouses were notified. Crowdsourcing can be used to improve the effectiveness of PS. Crowdsourcing is an approach that obtains solutions from communities. Crowdsourcing has been used effectively in public health to improve HIV testing, promote condom use, and monitor outbreaks. As a bottom-up approach, crowdsourcing can effectively engage MSM and other stakeholders to contribute their voices to enhance understanding of HIV PS and design participant-oriented interventions. Crowdsourced messages developed for PS may resonate more strongly with MSM compared to traditional PS messages. In turn, this could lead to increased community participation and acceptance of HIV PS, improving the effectiveness of HIV PS. We hypothesize that a crowdsourced HIV PS approach is feasible and acceptable. We also hypothesize that, as compared to conventional PS using referral cards (standard of care in China), will yield: a) more sexual partners reporting for HIV testing, and b) more sexual partners with confirmed HIV. Our multi-disciplinary research team brings together crowdsourcing and PS experience, a history of working with MSM in China, and a rich local infrastructure for HIV research, to investigate the following aims: (1) to develop a crowdsourced PS intervention for Chinese MSM using open contests; (2) to test the feasibility, acceptability and pilot the preliminary impact of crowdsourced PS with conventional PS on promoting HIV testing uptake among partners of newly identified MSM cases using a pilot randomized controlled trial. In this pilot project, we will first use open contests to develop a crowdsourced PS intervention for Chinese MSM, then we will conduct a pilot RCT in which index MSM cases are randomized to receive crowdsourced intervention or standard of care in a ratio of 2:1. The project will develop crowdsourced intervention strategies for promoting HIV PS, and collect preliminary data for a full RCT that aims to further evaluate the efficacy and cost-effectiveness of crowdsourced PS in multiple Chinese cities. ?

项目标题：增强与艾滋病毒男性发生性关系的男性中的伴侣服务： 飞行员随机对照试验 尽管全球控制关键人群中的艾滋病毒的努力，但与之发生性关系的男性中的新感染 男性（MSM）仍在增加。为了应对这一挑战，具有高效力的艾滋病毒预防策略是 迫切需要。合作伙伴服务（PS），告知潜在风险性的过程 合作伙伴是艾滋病毒预防的基石。 PS对于识别病例很重要，减少重新感染 费率，促进与护理的联系以及降低成本。但是，卫生提供者和 指数案例限制了PS的功效。结果，PS在包括中国在内的许多国家都没有用 仅通知只有16％的指数HIV病例配偶。众包可用于改善 PS的有效性。众包是一种从社区获得解决方案的方法。 众包已有效地用于公共卫生，以改善艾滋病毒测试，促进避孕套的使用和 监测暴发。作为一种自下而上的方法，众包可以有效吸引MSM和其他 利益相关者贡献自己的声音，以增强对艾滋病毒PS和设计参与者的理解 干预措施。为PS开发的众包消息可能会与MSM更加强烈共鸣 传统的PS消息。反过来，这可能导致社区参与和接受 HIV PS，提高了HIV PS的有效性。我们假设众包HIV PS的方法是 可行和可接受。我们还假设，与传统的PS使用推荐卡相比 （中国的护理标准），将产生：a）更多的性伴侣报告艾滋病毒测试，b）更多性 与确认的艾滋病毒的合作伙伴。我们的多学科研究团队汇集了众包和PS 经验，与中国MSM合作的历史以及艾滋病毒研究的丰富当地基础设施 调查以下目的：（1）使用Open开发中国MSM的众包PS干预 比赛； （2）测试可行性，可接受性和驾驶性的众包PS的初步影响 常规PS使用A 飞行员随机对照试验。在这个试点项目中，我们将首先使用公开比赛来开发 众包PS干预中国MSM，然后我们将进行索引MSM的飞行员RCT 案例被随机接受以2：1的比例接受众包干预或护理标准。项目 将制定众包干预策略来促进艾滋病毒PS，并收集初步数据 旨在进一步评估众包PS的功效和成本效益的完整RCT 中国城市。 ？

项目成果

Immune response and safety to inactivated COVID-19 vaccine: a comparison between people living with HIV and HIV-naive individuals.

• DOI: 10.1186/s12981-022-00459-y
• 发表时间: 2022-07-05
• 期刊: AIDS research and therapy
• 影响因子: 2.2

Humoral Immune Response to Inactivated COVID-19 Vaccination at the 3rd Month among People Living with HIV.

HIV 感染者在第 3 个月对灭活 COVID-19 疫苗接种的体液免疫反应。

• DOI: 10.21203/rs.3.rs-1750225/v1
• 发表时间: 2022
• 期刊: Research square
• 作者: Wu,Songjie;Zou,Shi;Ming,Fangzhao;Wu,Mengmeng;Guo,Wei;Xing,Zhongyuan;Zhang,Zhiyue;Liu,Jinli;Tang,Weiming;Liang,Ke
• 通讯作者: Liang,Ke

A crowdsourced intervention to decrease hepatitis B stigma in men who have sex with men in China: A cohort study.

• DOI: 10.1111/jvh.13213
• 发表时间: 2020-02
• 期刊: Journal of viral hepatitis
• 影响因子: 2.5
• 作者: Shen K;Yang NS;Huang W;Fitzpatrick TS;Tang W;Zhao Y;Wang Y;Li L;Tucker JD
• 通讯作者: Tucker JD

Monetary incentives and peer referral in promoting digital network-based secondary distribution of HIV self-testing among men who have sex with men in China: study protocol for a three-arm randomized controlled trial.

• DOI: 10.1186/s12889-020-09048-y
• 发表时间: 2020-06-12
• 期刊: BMC public health
• 影响因子: 4.5
• 作者: Lu, Ying;Ni, Yuxin;Tang, Weiming
• 通讯作者: Tang, Weiming

Willingness to Receive COVID-19 Vaccination Among People Living With HIV and AIDS in China: Nationwide Cross-sectional Online Survey.

• DOI: 10.2196/31125
• 发表时间: 2021-10-21
• 期刊: JMIR public health and surveillance
• 影响因子: 8.5
• 作者: Huang X;Yu M;Fu G;Lan G;Li L;Yang J;Qiao Y;Zhao J;Qian HZ;Zhang X;Liu X;Jin X;Chen G;Jiang H;Tang W;Wang Z;Xu J
• 通讯作者: Xu J