骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用-猫眼课题宝

骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用

批准号：

10226799

负责人：

Hugo Guerrero-Cazares

金额：

$21.06万

依托单位：

MAYO CLINIC JACKSONVILLE

依托单位国家：

美国

项目类别：

财政年份：

2019

资助国家：

美国

项目状态：

已结题

起止时间：

2019-05-01 至 2022-04-30

来源：

https://reporter.nih.gov/project-details/10226799

关键词：

Adult Affect Animal Model Applications Grants Binding Bioinformatics Biological Biopsy Blocking Antibodies Brain Neoplasms CD44 gene Cell Proliferation Cell Survival Cells Cerebrospinal Fluid Chemotherapy and/or radiation DNA Damage Data Diagnosis Distal Encapsulated FDA approved Family Gene Expression Profile Genes Glioblastoma Glioma Glycoproteins Goals Human Hydrogels Implant In Vitro Intrathecal Injections Lead Location Malignant - descriptor Malignant Neoplasms Mentored Research Scientist Development Award Operative Surgical Procedures Pathway interactions Patients Pharmaceutical Preparations Play Primary Brain Neoplasms Proteins Recombinants Recurrence Reporting Role Sampling Scientist Secure Speed Testing Translational Research base career cell motility differential expression experimental study gain of function genetic signature in vivo inhibitor/antagonist lateral ventricle loss of function malignant phenotype member migration neoplastic cell nerve stem cell osteopontin overexpression pluripotency pre-clinical prenylation response self-renewal skills stemness subventricular zone targeted treatment therapy resistant transcriptome sequencing tumor tumor progression whole genome

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英文摘要

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with a median survival of only 14 months after diagnosis, despite optimal surgery, chemotherapy, and radiation. Patients whose GBMs infiltrate the wall of the lateral ventricles (LV) have a substantially shorter survival than those whose tumors are located away from the LV, for reasons that remain unknown. Cerebrospinal fluid (CSF) in the LV can regulate the differentiation and migration of normal neural progenitor cells. We propose by analogy that LV-infiltrating GBMs also can interact with components of the CSF, and that this interaction makes these tumors more malignant. This proposal will study the interaction of human GBM cells and CSF. Particularly it will be focused on determining whether the osteopontin-CD44 axis plays a role in the response of GBM cells to CSF. This K01 award will allow Dr. Hugo Guerrero-Cazares to solidify his career as an independent scientist, develop bioinformatics and translational research skills and secure the preliminary information for a successful R01 grant application

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