Role of Human Cerebrospinal Fluid Chemokines in the Invasiveness of Human Glioblastoma
Role of Human Cerebrospinal Fluid Chemokines in the Invasiveness of Human Glioblastoma
批准号:
9544413
负责人:
Hugo Guerrero-Cazares
金额:
$0.34万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-15 至 2018-08-31
关键词:
AdultAffectAggressive behaviorBehaviorBrain NeoplasmsCell Culture TechniquesCellsCerebrospinal FluidChoroidDataDistantDrosophila sli proteinExcisionFoundationsFractionationGlioblastomaGliomaGoalsHumanIn VitroIntrathecal InjectionsIpsilateralLeadLigandsLocationMalignant - descriptorMalignant NeoplasmsModelingMusOperative Surgical ProceduresOutcomePathway interactionsPatientsPilot ProjectsPlayPopulationPrimary Brain NeoplasmsRadiationRadiation therapyRadioRecurrenceReportingResearchRodentRoleSamplingSchemeSignal TransductionSpeedSurvival RateTestingTherapeuticTherapeutic InterventionTissuesTumor Cell InvasionTumor InitiatorsUndifferentiatedVentricularcancer cellcell motilitycerebrospinal fluid flowchemokinechemotherapyhuman migrationhuman tissueimprovedin vivoinnovationinterestknock-downlateral ventriclemigrationnegative affectnerve stem celloutcome forecastprogramsreceptorresponseself-renewalsubventricular zonetargeted treatmenttherapeutic targettumortumor growthtumor progressionvirtual
中文摘要
项目摘要
胶质母细胞瘤(GBM)是成人中最常见的、侵袭性的和增殖性的原发性脑肿瘤,尽管目前的研究表明,
结合联合收割机手术、放疗和化疗的治疗策略。GBM的高侵袭能力使总的
手术切除几乎不可能,导致极高的复发率。形成新肿瘤的能力
存在于GBM内称为脑肿瘤起始细胞(BTIC)的细胞亚群中。BTIC未分化
具有自我更新和多能性能力的细胞,还具有在体内形成肿瘤的能力。本集团与
其他人报道,在原发性GBM中,那些位于侧脑室(LV)附近的GBM
多个不同的特征,包括远处复发增加,这对患者的生存产生了负面影响。
左心室近端GBM患者结局恶化的原因尚不清楚。可能的解释可能
涉及这些肿瘤接近脑脊液(CSF)和脑室下区的神经源性龛
(SVZ)。在初步研究中,我们已经确定人非癌CSF在体外排斥BTIC迁移。的分子
在CSF中负责这种影响是未知的。在这里,我们建议研究BTIC之间的相互作用,
CSF的不同部分。我们假设CSF可以诱导GBM细胞更具攻击性的行为。我们将
使用术中人体组织进行这项研究。完成这项研究后,我们将获得更好的
了解CSF对GBM细胞的影响,并将发现CSF中影响GBM细胞的可能因素。
BTIC和癌症进展。最终,我们希望揭示治疗干预的具体目标,
GBM患者的生存率增加。
英文摘要
PROJECT SUMMARY
Glioblastoma (GBM) is the most common, aggressive and proliferative primary brain tumor in adults despite current
therapeutic strategies that combine surgery, radio, and chemotherapy. The high invasive capacity of GBM makes total
surgical resection virtually impossible, resulting in an extremely high recurrence rate. The ability to form a new tumor
resides in a subpopulation of cells within the GBM called brain tumor initiating cells (BTICs). BTICs are undifferentiated
cells with self-renewing and pluripotential capacity, with the added ability of forming tumors in vivo. Our group and
others have reported that among primary GBMs, those located in close proximity to the lateral ventricles (LV) present
multiple distinct features, including increased recurrence at distant locations, which negatively affect patients' survival.
The cause for worse outcomes in patients suffering LV-proximal GBMs is not known. Possible explanations may
involve the proximity of these tumors to the cerebrospinal fluid (CSF) and neurogenic niche in the sub-ventricular zone
(SVZ). In a pilot study, we have determined that human non-cancer CSF repels BTICs migration in vitro. The molecules
in the CSF responsible for this effect are not known. Here we propose to study the interactions between BTICs and
different fractions of CSF. We hypothesize that CSF can induce a more aggressive behavior of GBM cells. We will
perform this research using intraoperative human tissue. Upon completion of this study we will have gained a better
understanding of the effects of CSF on GBM cells and will have discovered possible factors within CSF which influence
BTICs and cancer progression. Ultimately, we hope to reveal specific targets for therapeutic intervention leading to
increased survival in patients with GBM.
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会议论文
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
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批准号:10628557
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项目类别:
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资助金额:$21.06万
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财政年份:2022
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负责人:Hugo Guerrero-Cazares
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依托单位:
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
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批准号:10688119
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项目类别:
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资助金额:$21.06万
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财政年份:2022
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负责人:Hugo Guerrero-Cazares
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依托单位:
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
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批准号:10226799
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项目类别:
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资助金额:$21.06万
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财政年份:2019
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负责人:Hugo Guerrero-Cazares
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依托单位:
Role of SerpinA3 in the response of glioblastoma to cerebrospinal fluid
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批准号:9925463
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项目类别:
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资助金额:$1.24万
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财政年份:2019
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负责人:Hugo Guerrero-Cazares
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依托单位:
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
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批准号:9923761
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项目类别:
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资助金额:$21.06万
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财政年份:2019
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负责人:Hugo Guerrero-Cazares
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依托单位:
Role of SerpinA3 in the response of glioblastoma to cerebrospinal fluid
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批准号:9789384
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项目类别:
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资助金额:$14.52万
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财政年份:2018
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负责人:Hugo Guerrero-Cazares
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依托单位:
海外基金