Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用
基本信息
- 批准号:10628557
- 负责人:
- 金额:$ 21.06万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-01 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AdultAffectAnimal ModelApplications GrantsBindingBioinformaticsBiologicalBiopsyBlocking AntibodiesBrain NeoplasmsCD44 geneCell ProliferationCell SurvivalCellsCerebrospinal FluidChemotherapy and/or radiationDNA DamageDataDiagnosisDistalEncapsulatedFDA approvedFamilyGene Expression ProfileGenesGlioblastomaGliomaGlycoproteinsGoalsHumanHydrogelsImplantIn VitroIntrathecal InjectionsLeadLocationMalignant - descriptorMalignant NeoplasmsMentored Research Scientist Development AwardOperative Surgical ProceduresPathway interactionsPatientsPharmaceutical PreparationsPlayPrimary Brain NeoplasmsProteinsRecombinantsRecurrenceReportingRoleSamplingScientistSecureSpeedTestingTranslational Researchbasecareercell motilitydifferential expressionexperimental studygain of functiongenetic signaturein vivoinhibitorlateral ventricleloss of functionmalignant phenotypemembermigrationneoplastic cellnerve stem cellosteopontinoverexpressionpluripotencypre-clinicalprenylationresponseself-renewalskillsstemnesssubventricular zonetargeted treatmenttherapy resistanttranscriptome sequencingtumortumor progressionwhole genome
项目摘要
Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults,
with a median survival of only 14 months after diagnosis, despite optimal surgery,
chemotherapy, and radiation. Patients whose GBMs infiltrate the wall of the lateral
ventricles (LV) have a substantially shorter survival than those whose tumors are located
away from the LV, for reasons that remain unknown. Cerebrospinal fluid (CSF) in the LV
can regulate the differentiation and migration of normal neural progenitor cells. We
propose by analogy that LV-infiltrating GBMs also can interact with components of the
CSF, and that this interaction makes these tumors more malignant. This proposal will
study the interaction of human GBM cells and CSF. Particularly it will be focused on
determining whether the osteopontin-CD44 axis plays a role in the response of GBM
cells to CSF. This K01 award will allow Dr. Hugo Guerrero-Cazares to solidify his career
as an independent scientist, develop bioinformatics and translational research skills and
secure the preliminary information for a successful R01 grant application
胶质母细胞瘤(GBM)是成人中最常见和最具侵袭性的原发性脑肿瘤,
诊断后的中位生存期仅为14个月,尽管进行了最佳手术,
化疗和放疗GBM浸润外侧壁的患者
心室(LV)的生存期明显短于肿瘤位于
远离左心室,原因尚不清楚。LV中的脑脊液(CSF)
可调节正常神经前体细胞的分化和迁移。我们
通过类比提出,LV渗透GBM也可以与GBM的组分相互作用。
这种相互作用使这些肿瘤更加恶性。这项建议会
研究人GBM细胞和CSF的相互作用。它将特别关注
确定骨桥蛋白-CD 44轴是否在GBM的反应中起作用
细胞到CSF。这个K 01奖项将使Hugo Guerrero-Cazares博士能够巩固他的职业生涯
作为一名独立的科学家,发展生物信息学和转化研究技能,
确保成功申请R 01资助的初步信息
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Hugo Guerrero-Cazares其他文献
Hugo Guerrero-Cazares的其他文献
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{{ truncateString('Hugo Guerrero-Cazares', 18)}}的其他基金
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用
- 批准号:
10688119 - 财政年份:2022
- 资助金额:
$ 21.06万 - 项目类别:
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用
- 批准号:
10226799 - 财政年份:2019
- 资助金额:
$ 21.06万 - 项目类别:
Role of SerpinA3 in the response of glioblastoma to cerebrospinal fluid
SerpinA3在胶质母细胞瘤对脑脊液反应中的作用
- 批准号:
9925463 - 财政年份:2019
- 资助金额:
$ 21.06万 - 项目类别:
Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma
骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用
- 批准号:
9923761 - 财政年份:2019
- 资助金额:
$ 21.06万 - 项目类别:
Role of SerpinA3 in the response of glioblastoma to cerebrospinal fluid
SerpinA3在胶质母细胞瘤对脑脊液反应中的作用
- 批准号:
9789384 - 财政年份:2018
- 资助金额:
$ 21.06万 - 项目类别:
Role of Human Cerebrospinal Fluid Chemokines in the Invasiveness of Human Glioblastoma
人脑脊液趋化因子在人胶质母细胞瘤侵袭性中的作用
- 批准号:
9544413 - 财政年份:2016
- 资助金额:
$ 21.06万 - 项目类别:
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