Osteopontin-CD44 role in the malignancy of lateral ventricle infiltrating glioblastoma

骨桥蛋白-CD44在侧脑室浸润性胶质母细胞瘤恶性肿瘤中的作用

• 批准号: 10628557
• 负责人: Hugo Guerrero-Cazares
• 金额: $ 21.06万
• 依托单位: MAYO CLINIC JACKSONVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10628557
• 关键词: Adult; Affect; Animal Model; Applications Grants; Binding; Bioinformatics; Biological; Biopsy; Blocking Antibodies; Brain Neoplasms; CD44 gene; Cell Proliferation; Cell Survival; Cells; Cerebrospinal Fluid; Chemotherapy and/or radiation; DNA Damage; Data; Diagnosis; Distal; Encapsulated; FDA approved; Family; Gene Expression Profile; Genes; Glioblastoma; Glioma; Glycoproteins; Goals; Human; Hydrogels; Implant; In Vitro; Intrathecal Injections; Lead; Location; Malignant - descriptor; Malignant Neoplasms; Mentored Research Scientist Development Award; Operative Surgical Procedures; Pathway interactions; Patients; Pharmaceutical Preparations; Play; Primary Brain Neoplasms; Proteins; Recombinants; Recurrence; Reporting; Role; Sampling; Scientist; Secure; Speed; Testing; Translational Research; base; career; cell motility; differential expression; experimental study; gain of function; genetic signature; in vivo; inhibitor; lateral ventricle; loss of function; malignant phenotype; member; migration; neoplastic cell; nerve stem cell; osteopontin; overexpression; pluripotency; pre-clinical; prenylation; response; self-renewal; skills; stemness; subventricular zone; targeted treatment; therapy resistant; transcriptome sequencing; tumor; tumor progression; whole genome

Glioblastoma (GBM) is the most common and aggressive primary brain tumor in adults, with a median survival of only 14 months after diagnosis, despite optimal surgery, chemotherapy, and radiation. Patients whose GBMs infiltrate the wall of the lateral ventricles (LV) have a substantially shorter survival than those whose tumors are located away from the LV, for reasons that remain unknown. Cerebrospinal fluid (CSF) in the LV can regulate the differentiation and migration of normal neural progenitor cells. We propose by analogy that LV-infiltrating GBMs also can interact with components of the CSF, and that this interaction makes these tumors more malignant. This proposal will study the interaction of human GBM cells and CSF. Particularly it will be focused on determining whether the osteopontin-CD44 axis plays a role in the response of GBM cells to CSF. This K01 award will allow Dr. Hugo Guerrero-Cazares to solidify his career as an independent scientist, develop bioinformatics and translational research skills and secure the preliminary information for a successful R01 grant application

胶质母细胞瘤（GBM）是成人中最常见和最具侵袭性的原发性脑肿瘤， 诊断后的中位生存期仅为14个月，尽管进行了最佳手术， 化疗和放疗GBM浸润外侧壁的患者 心室（LV）的生存期明显短于肿瘤位于 远离左心室，原因尚不清楚。LV中的脑脊液（CSF） 可调节正常神经前体细胞的分化和迁移。我们 通过类比提出，LV渗透GBM也可以与GBM的组分相互作用。 这种相互作用使这些肿瘤更加恶性。这项建议会 研究人GBM细胞和CSF的相互作用。它将特别关注 确定骨桥蛋白-CD 44轴是否在GBM的反应中起作用 细胞到CSF。这个K 01奖项将使Hugo Guerrero-Cazares博士能够巩固他的职业生涯 作为一名独立的科学家，发展生物信息学和转化研究技能， 确保成功申请R 01资助的初步信息