Skeletal Health and Bone Marrow Composition Among Youth

青少年骨骼健康和骨髓成分

基本信息

  • 批准号:
    10401768
  • 负责人:
  • 金额:
    $ 58.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-04-06 至 2025-03-31
  • 项目状态:
    未结题

项目摘要

ABSTRACT Transgender youth with gender dysphoria are often treated with a gonadotropin-releasing hormone (GnRH) agonist to suppress sex steroids and pubertal development. However, there is little information available on its effects on bone health in young peri-pubertal transgender youth. Sex steroid suppression can alter mesenchymal stem cells to differentiate preferentially into adipocytes over osteoblasts, compromising osteogenesis, bone formation, and bone density in both adolescents and adults. The current investigators have previously demonstrated that adolescents with restrictive eating disorders and hypoestrogenism experience bone marrow shifts from red (hematopoietic) to yellow (fatty) marrow with progression of disease. These bone marrow changes may have adverse long-term implications for bone formation, bone accretion during adolescence, and ultimately, lifetime skeletal health. Examining how bone marrow composition is altered after pubertal blockade in transgender youth, and its relation to bone density, structure, and cross-sectional geometry, could provide a mechanistic understanding of the effects of a GnRH agonist on a young, immature skeleton. This proposal will examine the skeletal effects of pubertal blockade, the initial phase of transgender medical management, prior to gender affirming hormonal therapy (estrogen or testosterone therapy). The study will provide new insights on bone health in transgender youth, examining bone marrow composition via magnetic resonance imaging (MRI) and spectroscopy (MRS). These results will be correlated with BMD measurements obtained by the clinical assessment tool, dual-energy x-ray absorptiometry (DXA), and the research tool, peripheral quantitative computed tomography (pQCT). We will also address the clinically relevant question of how bone marrow composition relates to bone density and skeletal strength in young adolescents who are undergoing pubertal blockade. We will recruit a cohort of adolescents including those assigned female at birth (AFAB) and assigned male at birth (AMAB), and matched healthy controls, and examine bone marrow composition (by MRI/MRS), bone density (by DXA + pQCT), and bone structure and cross-sectional geometry (by pQCT), before and after 12 months of pubertal blockade. This project will leverage our large patient population as a two-site study in nationally recognized pediatric hospitals and our extensive experience with DXA, pQCT, and MRI/MRS. In an exploratory aim, we will also consider the effect of pubertal blockade on anxiety, depression, and health-related quality of life. Findings from the proposed study will allow us to identify preventive strategies to counter potential long-term adverse sequelae of pubertal blockade such as early osteoporosis and fractures, raise awareness for providers of transgender youth, and help guide monitoring after receipt of a GnRH agonist.
摘要

项目成果

期刊论文数量(0)
专著数量(0)
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CATHERINE M. GORDON其他文献

CATHERINE M. GORDON的其他文献

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{{ truncateString('CATHERINE M. GORDON', 18)}}的其他基金

Skeletal Health and Bone Marrow Composition in Transgender Youth
跨性别青年的骨骼健康和骨髓成分
  • 批准号:
    10707623
  • 财政年份:
    2020
  • 资助金额:
    $ 58.29万
  • 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
  • 批准号:
    8468645
  • 财政年份:
    2011
  • 资助金额:
    $ 58.29万
  • 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
  • 批准号:
    8664813
  • 财政年份:
    2011
  • 资助金额:
    $ 58.29万
  • 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
  • 批准号:
    9115311
  • 财政年份:
    2011
  • 资助金额:
    $ 58.29万
  • 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
  • 批准号:
    8509337
  • 财政年份:
    2011
  • 资助金额:
    $ 58.29万
  • 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
  • 批准号:
    8083110
  • 财政年份:
    2011
  • 资助金额:
    $ 58.29万
  • 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
  • 批准号:
    8304990
  • 财政年份:
    2011
  • 资助金额:
    $ 58.29万
  • 项目类别:
ALENDRONATE FOR GLUCOCORTICOID-ASSOCIATED OSTEOPENIA
阿仑膦酸钠治疗糖皮质激素相关骨质减少症
  • 批准号:
    7607239
  • 财政年份:
    2007
  • 资助金额:
    $ 58.29万
  • 项目类别:
EFFECTS OF ADRENAL & GONADAL HORMONE REPLACEMENT IN YOUNG WOMEN W/AN
肾上腺的作用
  • 批准号:
    7607236
  • 财政年份:
    2007
  • 资助金额:
    $ 58.29万
  • 项目类别:
TREATMENT OF SUBCLINICAL VIT D DEFICIENCY AND RICKETS INFANTS/TODDLERS
亚临床维生素 D 缺乏症和婴儿/幼儿佝偻病的治疗
  • 批准号:
    7607266
  • 财政年份:
    2007
  • 资助金额:
    $ 58.29万
  • 项目类别:

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