Skeletal Health and Bone Marrow Composition Among Youth
青少年骨骼健康和骨髓成分
基本信息
- 批准号:10401768
- 负责人:
- 金额:$ 58.29万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-04-06 至 2025-03-31
- 项目状态:未结题
- 来源:
- 关键词:AddressAdipocytesAdolescenceAdolescentAdultAdverse effectsAffectAgeAgonistAnxietyAwarenessBeck depression inventoryBirthBody mass indexBone DensityBone MarrowBone structureChildChild HealthClinical Assessment ToolDataDevelopmentDisease ProgressionDistressDual-Energy X-Ray AbsorptiometryEating DisordersEquipment and supply inventoriesEstrogensEthnic OriginFatty acid glycerol estersFeelingFemaleFractureGenderGeometryGoalsGonadal Steroid HormonesGonadotropin Hormone Releasing HormoneHealthHematopoieticHormonalHormonesInterventionLipidsLong-Term EffectsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMarrowMeasurementMeasuresMedicalMental DepressionMental HealthMesenchymal Stem CellsMonitorObesityOsteoblastsOsteogenesisOsteoporosisOutcomeParticipantPatient Self-ReportPediatric HospitalsPeripheralPhasePrevention strategyProfessional OrganizationsProviderPubertyQuestionnairesRaceResearchResearch PersonnelSex CharacteristicsSiteSkeletonSpectrum AnalysisStructureTestosteroneTimeTranslatingWell in selfWorkX-Ray Computed TomographyYellow MarrowYouthbonebone healthbone massclinically relevantclinically significantcohortcritical periodexperiencefracture riskgender dysphoriahealth related quality of lifehormone therapyinsightmalepatient populationphysical conditioningrecruitrestrictive eatingsexskeletalspectroscopic imagingtooltraittransgender
项目摘要
ABSTRACT
Transgender youth with gender dysphoria are often treated with a gonadotropin-releasing hormone (GnRH)
agonist to suppress sex steroids and pubertal development. However, there is little information available on its
effects on bone health in young peri-pubertal transgender youth. Sex steroid suppression can alter
mesenchymal stem cells to differentiate preferentially into adipocytes over osteoblasts, compromising
osteogenesis, bone formation, and bone density in both adolescents and adults. The current investigators have
previously demonstrated that adolescents with restrictive eating disorders and hypoestrogenism experience
bone marrow shifts from red (hematopoietic) to yellow (fatty) marrow with progression of disease. These bone
marrow changes may have adverse long-term implications for bone formation, bone accretion during
adolescence, and ultimately, lifetime skeletal health. Examining how bone marrow composition is altered after
pubertal blockade in transgender youth, and its relation to bone density, structure, and cross-sectional
geometry, could provide a mechanistic understanding of the effects of a GnRH agonist on a young, immature
skeleton. This proposal will examine the skeletal effects of pubertal blockade, the initial phase of transgender
medical management, prior to gender affirming hormonal therapy (estrogen or testosterone therapy). The
study will provide new insights on bone health in transgender youth, examining bone marrow composition via
magnetic resonance imaging (MRI) and spectroscopy (MRS). These results will be correlated with BMD
measurements obtained by the clinical assessment tool, dual-energy x-ray absorptiometry (DXA), and the
research tool, peripheral quantitative computed tomography (pQCT). We will also address the clinically
relevant question of how bone marrow composition relates to bone density and skeletal strength in young
adolescents who are undergoing pubertal blockade. We will recruit a cohort of adolescents including those
assigned female at birth (AFAB) and assigned male at birth (AMAB), and matched healthy controls, and
examine bone marrow composition (by MRI/MRS), bone density (by DXA + pQCT), and bone structure and
cross-sectional geometry (by pQCT), before and after 12 months of pubertal blockade. This project will
leverage our large patient population as a two-site study in nationally recognized pediatric hospitals and our
extensive experience with DXA, pQCT, and MRI/MRS. In an exploratory aim, we will also consider the effect of
pubertal blockade on anxiety, depression, and health-related quality of life. Findings from the proposed study
will allow us to identify preventive strategies to counter potential long-term adverse sequelae of pubertal
blockade such as early osteoporosis and fractures, raise awareness for providers of transgender youth, and
help guide monitoring after receipt of a GnRH agonist.
摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
CATHERINE M. GORDON其他文献
CATHERINE M. GORDON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('CATHERINE M. GORDON', 18)}}的其他基金
Skeletal Health and Bone Marrow Composition in Transgender Youth
跨性别青年的骨骼健康和骨髓成分
- 批准号:
10707623 - 财政年份:2020
- 资助金额:
$ 58.29万 - 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
- 批准号:
8468645 - 财政年份:2011
- 资助金额:
$ 58.29万 - 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
- 批准号:
8664813 - 财政年份:2011
- 资助金额:
$ 58.29万 - 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
- 批准号:
9115311 - 财政年份:2011
- 资助金额:
$ 58.29万 - 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
- 批准号:
8509337 - 财政年份:2011
- 资助金额:
$ 58.29万 - 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
- 批准号:
8083110 - 财政年份:2011
- 资助金额:
$ 58.29万 - 项目类别:
Effect of Adrenal and Gonadal Hormones on Bone Marrow and Appendicular BMD
肾上腺和性腺激素对骨髓和四肢 BMD 的影响
- 批准号:
8304990 - 财政年份:2011
- 资助金额:
$ 58.29万 - 项目类别:
ALENDRONATE FOR GLUCOCORTICOID-ASSOCIATED OSTEOPENIA
阿仑膦酸钠治疗糖皮质激素相关骨质减少症
- 批准号:
7607239 - 财政年份:2007
- 资助金额:
$ 58.29万 - 项目类别:
EFFECTS OF ADRENAL & GONADAL HORMONE REPLACEMENT IN YOUNG WOMEN W/AN
肾上腺的作用
- 批准号:
7607236 - 财政年份:2007
- 资助金额:
$ 58.29万 - 项目类别:
TREATMENT OF SUBCLINICAL VIT D DEFICIENCY AND RICKETS INFANTS/TODDLERS
亚临床维生素 D 缺乏症和婴儿/幼儿佝偻病的治疗
- 批准号:
7607266 - 财政年份:2007
- 资助金额:
$ 58.29万 - 项目类别:
相似国自然基金
支链氨基酸代谢紊乱调控“Adipocytes - Macrophages Crosstalk”诱发2型糖尿病脂肪组织功能和结构障碍的作用及机制
- 批准号:81970721
- 批准年份:2019
- 资助金额:55.0 万元
- 项目类别:面上项目
相似海外基金
New development of cellular regeneration therapy in jaw bone using stem cells derived from adipocytes jaw bone
利用颌骨脂肪细胞来源的干细胞进行颌骨细胞再生治疗的新进展
- 批准号:
23K16058 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
A novel mechanism of insulin resistance mediated by uric acid metabolism in adipocytes
脂肪细胞尿酸代谢介导胰岛素抵抗的新机制
- 批准号:
23K10969 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Hypertrophic adipocytes as biophysical mediators of breast cancer progression
肥大脂肪细胞作为乳腺癌进展的生物物理介质
- 批准号:
10751284 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Elucidation of mechanisms for conversion of adipocytes to cancer-associated fibroblasts in osteosarcoma microenvironment
阐明骨肉瘤微环境中脂肪细胞转化为癌症相关成纤维细胞的机制
- 批准号:
23K19518 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Research Activity Start-up
Study on UCP-1 independent metabolic regulation by brown adipocytes
棕色脂肪细胞对UCP-1独立代谢调节的研究
- 批准号:
23K18303 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Development of adipocytes for gene therapy that avoids cellular stress due to overexpression of therapeutic proteins
开发用于基因治疗的脂肪细胞,避免因治疗蛋白过度表达而造成的细胞应激
- 批准号:
23H03065 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Functional analysis of bitter taste receptors in adipocytes and hepatocytes
脂肪细胞和肝细胞中苦味受体的功能分析
- 批准号:
23K05107 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
NKA/CD36 signaling in adipocytes promotes oxidative stress and drives chronic inflammation in atherosclerosis
脂肪细胞中的 NKA/CD36 信号传导促进氧化应激并驱动动脉粥样硬化的慢性炎症
- 批准号:
10655793 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
The mechanisms of the signal transduction from brown adipocytes to afferent neurons and its significance.
棕色脂肪细胞向传入神经元的信号转导机制及其意义。
- 批准号:
23K05594 - 财政年份:2023
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
NKT cell activation depend on lipid accumulation in adipocytes
NKT 细胞的激活取决于脂肪细胞中的脂质积累
- 批准号:
22K08679 - 财政年份:2022
- 资助金额:
$ 58.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)














{{item.name}}会员




