“Overlapping and Discrete Pathways Through Which Prenatal Isolation and Uncertainty Stress Impact Maternal Mental Health and Child Neurodevelopment

☀产前隔离和不确定性压力影响母亲心理健康和儿童神经发育的重叠和离散途径

• 批准号: 10231690
• 负责人: Natalie Hiromi Brito
• 金额: $ 87.11万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10231690
• 关键词: Address; Affect; Age; Allopregnanolone; Animals; Architecture; Area; Attention; Award; Behavior; Behavior assessment; Behavioral; Bioenergetics; Biological; Biology; Biophysics; Brain; COVID-19; COVID-19 pandemic; Child; Child Development; Collection; Communicable Diseases; Data Collection; Development; Diffusion; Disasters; Economics; Electrocardiogram; Electroencephalogram; Endocrine; Enrollment; Environment; Etiology; Event; Fatty Acids; Fiber; Foundations; Glucose; Goals; Health; Height; Home environment; Hormonal; Hour; Human; Human Development; Hydrocortisone; Infant; Inflammation; Inflammatory; Investigation; Knowledge; Learning; Leptin; Life; Literature; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Medical; Mental Health; Modality; Morbidity - disease rate; Mothers; Movement; Myelin; Neurocognitive; New York City; Outcome; Parents; Pathway interactions; Perinatal; Phase; Physiological; Play; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Prevalence; Psychopathology; Psychosocial Stress; Questionnaires; Relaxation; Research; Risk; Role; Sinus Arrhythmia; Social Environment; Social isolation; Societies; Stress; Sum; Supervision; Surveys; System; Testing; Time; Uncertainty; United States National Institutes of Health; Variant; Woman; Work; arm; awake; base; care providers; cohort; course development; experience; family support; follow-up; imaging approach; innovation; machine learning algorithm; multimodality; neurobehavior; neurobehavioral; neurobehavioral disorder; neurodevelopment; neuroimaging; new technology; offspring; pandemic disease; physical conditioning; postnatal; preclinical study; pregnant; prenatal; prospective; psychobiologic; psychobiology; psychologic; public health relevance; recruit; remote sensing; respiratory; response; restraint; sensor technology; serial imaging; sound; stressor; tool

PROJECT SUMMARY The prenatal period is regarded as one of the most sensitive phases in human development. Events that occur during gestation can alter the course of development with lasting impact. Presently, the COVID-19 pandemic is exerting wide-spread impact on the lives of expectant mothers around the world. Particularly salient pandemic- related stressors that are being experienced by pregnant women are social isolation and uncertainty stress. There is ample physiological and behavioral literature showing that social isolation and uncertainty stress affect typical human and animal psychobiological functioning, but there is an absence of knowledge about how these conditions might impact the physical and psychological health of a pregnant woman, and what the consequences of those changes might be for her developing child. The central objective of this proposal is to build foundational knowledge about the effects of prenatal social isolation and uncertainty stress on maternal psychobiology and infant neurobehavior. We will explore several candidate physiological systems in the mother to elucidate mechanisms that underlie associations between maternal stressors and child outcomes. To achieve these goals, we will recruit 200 women from a large New York City cohort established at the height of the pandemic into a prospective, longitudinal study that will include pre- and postnatal biospecimen collection and child neurobehavioral assessments at 6-, 12- and 24 months. Multi-modal neuroimaging strategies, including infant EEG and quantitative MRI, and innovative remote biophysical data collection strategies will be employed. The primary aims of this project are to (i) examine the impact of prenatal social isolation and uncertainty stress on maternal biology and postnatal mental health; (ii) evaluate the influence of maternal prenatal social isolation and uncertainty stress on infant neurobehavioral development; and (iii) examine the role of prenatal social isolation and uncertainty stress on mother-infant bi-directional interactions. We will thus be able to meaningfully evaluate whether, and how, prenatal social isolation and uncertainty stress modify maternal biology and affect, and the neurobehavioral consequences of those impacts on infants. Such work would constitute a substantial advance in our understanding of the longitudinal effects of prenatal psychosocial stress exposures, the underlying mechanistic pathways, and the origins of child neurobehavioral disorders.

项目总结