Investigating neurobehavioral consequences of COVID-19 related stressors on maternal mental health and infant development

调查 COVID-19 相关压力源对孕产妇心理健康和婴儿发育的神经行为影响

• 批准号: 10181743
• 负责人: Natalie Hiromi Brito
• 金额: $ 76.28万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10181743
• 关键词: Animals; Behavioral; Biological; Brain; Buffers; COVID-19; COVID-19 pandemic; Caring; Child; Child Development; Chronic stress; Collection; Communities; Contracts; Data; Data Set; Development; Economics; Electroencephalography; Enrollment; Environment; Environmental Risk Factor; Equilibrium; Event; Exposure to; Family; Financial Support; Foundations; Future; Goals; Hair; Health; Heart Rate; Height; Human; Human Milk; Hydrocortisone; Individual; Infant; Infant Development; Inflammation; Intervention; Lead; Life; Link; Long-Term Effects; Longitudinal Studies; Measures; Medical; Mental Health; Mother-Child Relations; Mothers; Neurobiology; Neurocognition; Neurocognitive; New York City; Outcome; Parent-Child Relations; Pathway interactions; Pattern; Perinatal; Personal Satisfaction; Physiological; Population; Postpartum Women; Pregnancy; Pregnant Women; Protocols documentation; Psychopathology; Recording of previous events; Research; Resources; Rest; Risk; Severities; Social support; Stress; Surveys; System; Testing; Time; Toddler; United States; Virus; Woman; Work; anxious behavior; base; biobehavior; brain behavior; caregiving; cognitive function; cohort; coronavirus disease; early life stress; economic impact; emotional distress; experience; gut microbiome; gut microbiota; health economics; improved; infancy; inflammatory marker; interest; maternal stress; neurobehavioral; neurodevelopment; neuropsychiatry; pandemic disease; perinatal period; postnatal; pregnant; prenatal; prospective; protective factors; psychosocial; public health emergency; recruit; response; social; social norm; sociodemographic factors; sociodemographics; stressor; transmission process

PROJECT SUMMARY Societal consequences of the COVID-19 pandemic are unprecedented. The global community has been crippled by a public health emergency that has had deleterious health and economic impacts, the scope of which has yet to be determined. As a result of the current crisis, pregnant women and new mothers are currently experiencing dramatic loss of medical, financial, and social support, resulting in higher rates of emotional distress. It is well established that chronic stress can be embedded in the developing neurobiological system, particularly during sensitive periods of life, but how the timing of maternal stressors and pathways through which these experiences impact child neurobehavioral development are unclear. The central objective of this proposal is to examine the association between perinatal COVID-19 stress and longitudinal postnatal brain development, and to rigorously evaluate timing of exposure, underlying biological mechanisms and postnatal protective factors. We will enroll 300 women and children from the New York City (NYC) COVID-19 Perinatal Experiences (COPE) cohort into a longitudinal protocol that will measure child biobehavioral outcomes at 12-, 24-, and 36-months. The COPE cohort is comprised of more than 900 women that were enrolled into a longitudinal assessment protocol at the height of the pandemic, approximately half of which were pregnant (54%) and half of which were new mothers (46%). The primary aims of this project are to (i) identify key windows of perinatal stress vulnerability; (ii) evaluate biological pathways that underlie associations between maternal COVID-19 stressors and infant neurocognition; and (iii) isolate protective factors in the postnatal environment that promote resilient outcomes in children exposed to extreme perinatal stress. We will selectively recruit the proposed subsample for this study based on balance of timing of exposure, severity of stressors, and sociodemographic factors. We will thus be able to meaningfully evaluate biological consequences of perinatal stress with control over both timing and aggregate risk. Such work would constitute a substantial advance in our understanding of the longitudinal effects of maternal perinatal stress on early human brain development and would also offer potential avenues for promoting healthy outcomes in children born at the height of history’s most significant perinatal stressor.

项目摘要 共同19-19大流行的社会后果是前所未有的。全球社区一直是 受到有害健康和经济影响的公共卫生紧急紧急事件的瘫痪，范围 尚未确定。由于当前的危机，孕妇和新母亲是 目前正在遭受医疗，财务和社会支持的巨大丧失，导致较高的比率 情绪困扰。众所周知，慢性应激可以嵌入发展中的神经生物学中 系统，尤其是在敏感时期，但如何 这些经历会影响儿童神经行为的发育尚不清楚。中心目标 该建议是检查围产期covid-19应激与纵向后产后之间的关联 大脑发育，并严格评估暴露时间，潜在的生物学机制和 产后保护因素。我们将招募来自纽约市Covid-19的300名妇女和儿童 围产期经验（COPE）队列成一个纵向方案，该方案将测量儿童生物行为 成果在12-、24和36个月。 Cope队列由900多名女性组成 在大流行高度的纵向评估方案中招募了大约一半 怀孕（54％），其中一半是新妈妈（46％）。该项目的主要目的是（i） 确定围产期应力脆弱性的关键窗口； （ii）评估基于关联的生物学途径 在Mater Covid-19压力源和婴儿神经认知之间； （iii）在 促进暴露于极端围产压力的儿童中弹性结局的产后环境。我们将 根据暴露时间的平衡，有选择地招募本研究的拟议子样本 压力源和社会人口统计学因素。因此，我们将能够有意义地评估生物学 围产期应力的后果以及对时间和总风险的控制。这样的工作将构成 我们对孕产妇围产压力对早期的纵向影响的理解有很大的进步 人脑发育，还将提供潜在的途径来促进儿童健康的结果 出生于历史最重要的围产期压力源。