Investigating neurobehavioral consequences of COVID-19 related stressors on maternal mental health and infant development

调查 COVID-19 相关压力源对孕产妇心理健康和婴儿发育的神经行为影响

• 批准号: 10181743
• 负责人: Natalie Hiromi Brito
• 金额: $ 76.28万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10181743
• 关键词: Animals; Behavioral; Biological; Brain; Buffers; COVID-19; COVID-19 pandemic; Caring; Child; Child Development; Chronic stress; Collection; Communities; Contracts; Data; Data Set; Development; Economics; Electroencephalography; Enrollment; Environment; Environmental Risk Factor; Equilibrium; Event; Exposure to; Family; Financial Support; Foundations; Future; Goals; Hair; Health; Heart Rate; Height; Human; Human Milk; Hydrocortisone; Individual; Infant; Infant Development; Inflammation; Intervention; Lead; Life; Link; Long-Term Effects; Longitudinal Studies; Measures; Medical; Mental Health; Mother-Child Relations; Mothers; Neurobiology; Neurocognition; Neurocognitive; New York City; Outcome; Parent-Child Relations; Pathway interactions; Pattern; Perinatal; Personal Satisfaction; Physiological; Population; Postpartum Women; Pregnancy; Pregnant Women; Protocols documentation; Psychopathology; Recording of previous events; Research; Resources; Rest; Risk; Severities; Social support; Stress; Surveys; System; Testing; Time; Toddler; United States; Virus; Woman; Work; anxious behavior; base; biobehavior; brain behavior; caregiving; cognitive function; cohort; coronavirus disease; early life stress; economic impact; emotional distress; experience; gut microbiome; gut microbiota; health economics; improved; infancy; inflammatory marker; interest; maternal stress; neurobehavioral; neurodevelopment; neuropsychiatry; pandemic disease; perinatal period; postnatal; pregnant; prenatal; prospective; protective factors; psychosocial; public health emergency; recruit; response; social; social norm; sociodemographic factors; sociodemographics; stressor; transmission process

PROJECT SUMMARY Societal consequences of the COVID-19 pandemic are unprecedented. The global community has been crippled by a public health emergency that has had deleterious health and economic impacts, the scope of which has yet to be determined. As a result of the current crisis, pregnant women and new mothers are currently experiencing dramatic loss of medical, financial, and social support, resulting in higher rates of emotional distress. It is well established that chronic stress can be embedded in the developing neurobiological system, particularly during sensitive periods of life, but how the timing of maternal stressors and pathways through which these experiences impact child neurobehavioral development are unclear. The central objective of this proposal is to examine the association between perinatal COVID-19 stress and longitudinal postnatal brain development, and to rigorously evaluate timing of exposure, underlying biological mechanisms and postnatal protective factors. We will enroll 300 women and children from the New York City (NYC) COVID-19 Perinatal Experiences (COPE) cohort into a longitudinal protocol that will measure child biobehavioral outcomes at 12-, 24-, and 36-months. The COPE cohort is comprised of more than 900 women that were enrolled into a longitudinal assessment protocol at the height of the pandemic, approximately half of which were pregnant (54%) and half of which were new mothers (46%). The primary aims of this project are to (i) identify key windows of perinatal stress vulnerability; (ii) evaluate biological pathways that underlie associations between maternal COVID-19 stressors and infant neurocognition; and (iii) isolate protective factors in the postnatal environment that promote resilient outcomes in children exposed to extreme perinatal stress. We will selectively recruit the proposed subsample for this study based on balance of timing of exposure, severity of stressors, and sociodemographic factors. We will thus be able to meaningfully evaluate biological consequences of perinatal stress with control over both timing and aggregate risk. Such work would constitute a substantial advance in our understanding of the longitudinal effects of maternal perinatal stress on early human brain development and would also offer potential avenues for promoting healthy outcomes in children born at the height of history’s most significant perinatal stressor.

项目概要 COVID-19 大流行的社会后果是前所未有的。国际社会已经 由于突发公共卫生事件对健康和经济产生了有害影响， 目前尚未确定。由于当前的危机，孕妇和新妈妈们 目前正经历着医疗、经济和社会支持的巨大损失，导致患病率上升 情绪困扰。众所周知，慢性压力可以嵌入正在发育的神经生物学中。 系统，特别是在生命的敏感时期，但母亲压力源的时间和途径如何 这些经历如何影响儿童神经行为发育尚不清楚。中心目标 该提案的目的是研究围产期 COVID-19 压力与纵向产后压力之间的关系 大脑发育，并严格评估暴露时间、潜在的生物机制和 产后保护因素。我们将招募 300 名来自纽约市 (NYC) COVID-19 的妇女和儿童 围产期经历 (COPE) 队列纳入纵向方案，用于测量儿童生物行为 12、24 和 36 个月的结果。 COPE 队列由 900 多名女性组成 在大流行最严重的时候加入了纵向评估方案，其中大约一半 已怀孕（54%），其中一半是新妈妈（46%）。该项目的主要目标是 (i) 确定围产期应激脆弱性的关键窗口； (ii) 评估关联背后的生物途径 母亲 COVID-19 压力源与婴儿神经认知之间的关系； (iii) 隔离保护因素 产后环境可促进暴露于极端围产期压力的儿童的恢复能力。我们将 根据暴露时间的平衡、暴露的严重程度，选择性地招募本研究中提议的子样本 压力源和社会人口因素。因此，我们将能够有意义地评估生物学 通过控制时间和总体风险来控制围产期应激的后果。此类工作将构成 我们对母亲围产期压力对早期妊娠的纵向影响的理解取得了重大进展 人脑发育，也将为促进儿童健康结果提供潜在途径 出生在历史上最重要的围产期压力源的高峰期。