Sibling Relations in the Context of Dementia Parental Care: Implications for Health and Well-Being

项目总结 我的长期目标是扩展我关于晚年家庭和幸福的研究议程，包括 创新观察和生物标记物方法，并发展有效的家庭干预 战略。拟议的项目将为我提供三个新领域的培训，这三个领域对于扩展我的 之前的训练。这些技能包括收集和分析(1)家庭成员的观察 相互作用；(2)压力、压力保护和免疫生物标记物；(3)将基础研究转化为 以家庭为基础的干预。这将使我能够研究家庭过程和生理过程之间的联系。 影响健康和福祉结果的机制。该项目还提供了基础知识 我可以将其应用于未来以家庭为基础的护理干预。拟议的项目将突出 家庭关系对照顾者身体健康和心理健康的影响 护理者被嵌入其中。该项目有三个目标：(1)确定人们对父母照顾的看法 护理分工中的公平偏好和感知影响兄弟姐妹互动策略和认同 兄弟姐妹互动策略对兄弟姐妹关系质量的影响，(2)确定压力和 响应兄弟姐妹相互作用的压力保护性生物标志物以及(3)确定兄弟姐妹的含义 ADRD护理期间的关系质量累积生物健康指标、心理幸福感 和身体健康。拟议的项目通过采用创新的组合来扩展之前的工作 从100个家庭的两个成年子女那里收集的调查、观察和生物标志物数据；这将是第一次 研究结合这三种类型的数据来研究照顾背景下的兄弟姐妹关系。本研究 通过使用成年兄弟姐妹在以下情况下使用的交互策略的观察性编码，其方法是新颖的 讨论他们父母过去和未来的护理需求；并评估他们对这些需求的生理反应 通过测量压力(即皮质醇)和压力保护性生物标志物(即脱氢表雄酮或 DHEA)。此外，我会考虑兄弟姐妹关系质量对累积压力、压力- 保护性和免疫性(即分泌型免疫球蛋白A(SIgA)、C反应蛋白(CRP)、白介素1-β(IL-β) 1β)和单纯疱疹病毒1型(HSV)生物标志物。这项研究的发现将填补关于以下方面的知识空白 成年子女在紧张的生活事件中的健康脆弱性。这项研究的洞察力有助于塑造 旨在改善兄弟姐妹互动战略和整体健康的未来预防和干预努力 成年子女照顾患有ADRD的年长父母的幸福感。

PROJECT SUMMARY My long-term goal is to extend my research agenda regarding later-life families and well-being by incorporating innovative observational and biomarker methodologies and to develop effective family-based intervention strategies. The proposed project will provide me with training in three new areas which are critical to extend my previous training. These skills include the collection and analysis of (1) observations of family members’ interactions, (2) stress, stress-protective and immune biomarkers and (3) the translation of basic research into family-based interventions. This will allow me to examine the links between family processes and biological mechanisms that influence health and well-being outcomes. This project also provides foundational knowledge which I can apply to future family-based caregiving interventions. The proposed project will highlight the role of family relations in caregivers’ physical health and psychological well-being by considering the network in which caregivers are embedded. This project has three aims: (1) Determine whether perceptions of parental care preferences and perceptions of equity in the division of care influence sibling interaction strategies and identify the implications of sibling interaction strategies on sibling relationship quality, (2) identify changes in stress and stress-protective biomarkers in response to sibling interactions and (3) identify the implications of sibling relationship quality during ADRD caregiving for cumulative biological health indicators, psychological well-being and physical health. The proposed project extends this previous work by employing an innovative combination of survey, observational and biomarker data collected from two adult children in 100 families; and will be the first study to combine these three types of data to study sibling relationships in the context of caregiving. This study is novel in its approach by employing observational coding of the interaction strategies adult siblings use when discussing their parents’ past and future care needs; and also assessing the physiological reactions to these interactions by measuring stress (i.e. cortisol) and stress-protective biomarkers (i.e. dehydroepiandrosterone or DHEA). Further, I will consider the consequences of sibling relationship quality on cumulative stress, stress- protective and immune (i.e. secretory immunoglobulin A (sIgA), C-reactive protein (CRP), interleukin 1-beta (IL- 1β) and herpes simplex virus-1 (HSV)) biomarkers. The findings from this study will fill a knowledge gap regarding the health vulnerability of adult children during a stressful life event. Insights from this study can help to shape future prevention and intervention efforts aimed at improving sibling interaction strategies and the overall health and well-being of adult children caring for older parents with ADRD.