Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
基本信息
- 批准号:10407038
- 负责人:
- 金额:$ 42.09万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:BiologicalChemicalsDNA biosynthesisDrug TargetingEngineeringEnzyme InhibitionEnzymesFamilyMetalsModificationOutcomeProcessReactionRouteStructureSystemTrace ElementsTransition ElementsWorkbiological systemschemical bondchemical reactioncofactorcomparativedrug synthesismetalloenzymenovelpathogenpathogenic bacteriatool
项目摘要
Project Summary
Enzymes that employ transition metals can initiate chemically challenging modifications
of inert chemical bonds. These systems serve as both important drug targets and useful
biocatalysts. In certain transition-metal driven essential biological transformations, such
as DNA biosynthesis, divergent trace elements can be used for reaction initiation.
Discovery of novel metal cofactors used for these processes, and their mechanisms of
assembly and deployment, will enable novel routes of enzyme inhibition in bacterial
pathogens. In a second project, structures and reaction mechanisms in three different
metalloenzyme superfamilies relevant to biocatalysis will be elucidated. These systems
use a common cofactor to catalyze divergent reaction outcomes, controlled by structural
features of each enzyme. A comparative approach provides detailed and testable
hypotheses about the means by which distinct chemical reactions are accomplished, as
well as discovery of entirely new families of enzymes and new ways to control their
activities. The objective of this work is to enable exploitation of the catalytic power
inherent in these systems for more efficient and environmentally friendly synthesis of
drugs, chemicals, technological tools, and new chemical processes.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amie K Boal其他文献
Amie K Boal的其他文献
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{{ truncateString('Amie K Boal', 18)}}的其他基金
SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS)
通过与教师一起进行主题建模来探索科学研究,塑造真实的实践(形状很重要)
- 批准号:
10623153 - 财政年份:2020
- 资助金额:
$ 42.09万 - 项目类别:
SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS)
通过与教师一起进行主题建模来探索科学研究,塑造真实的实践(形状很重要)
- 批准号:
9975283 - 财政年份:2020
- 资助金额:
$ 42.09万 - 项目类别:
SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS)
通过与教师一起进行主题建模来探索科学研究,塑造真实的实践(形状很重要)
- 批准号:
10385814 - 财政年份:2020
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
9324290 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10201240 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
9987124 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10728422 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
9142707 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10598851 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10621788 - 财政年份:2016
- 资助金额:
$ 42.09万 - 项目类别:
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