Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
基本信息
- 批准号:9142707
- 负责人:
- 金额:$ 37.68万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-01 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Project Summary
Enzymes that employ transition metals to initiate free-radical mechanisms require exquisite control of highly
reactive intermediates. The mechanism by which diverse outcomes can be controlled by similar enzyme
structures and active sites is not well understood. Global study of entire enzyme classes provides detailed,
testable hypotheses about the means by which distinct outcomes are accomplished, providing deeper insight
into the reactions catalyzed by individual members. This family-wide approach will be essential for controlling
these scaffolds, both in engineering of new protein-based catalysts and in targeting these systems for novel
antimicrobial therapeutics. This approach has already allowed for successful reengineering of non-native
activity into a new scaffold using observations gleaned from structural data. Continued work to reveal the
structural underpinnings of mechanism in complex metalloenzymes will enable exploitation of the seemingly
limitless catalytic capabilities of these systems in the design of new drugs, new technological tools, and new
chemical processes.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Amie K Boal其他文献
Amie K Boal的其他文献
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{{ truncateString('Amie K Boal', 18)}}的其他基金
SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS)
通过与教师一起进行主题建模来探索科学研究,塑造真实的实践(形状很重要)
- 批准号:
10623153 - 财政年份:2020
- 资助金额:
$ 37.68万 - 项目类别:
SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS)
通过与教师一起进行主题建模来探索科学研究,塑造真实的实践(形状很重要)
- 批准号:
9975283 - 财政年份:2020
- 资助金额:
$ 37.68万 - 项目类别:
SHaping of Authentic Practices by Engaging in Modeling of A Topic with Teachers to Explore Research in Science (SHAPE MATTERS)
通过与教师一起进行主题建模来探索科学研究,塑造真实的实践(形状很重要)
- 批准号:
10385814 - 财政年份:2020
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
9324290 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10201240 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
9987124 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10728422 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10407038 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10598851 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
绘制金属酶超家族机械多样性的结构基础
- 批准号:
10621788 - 财政年份:2016
- 资助金额:
$ 37.68万 - 项目类别:
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