Core D: Behavioral Phenotyping Core

核心 D：行为表型核心

• 批准号: 10229596
• 负责人: Fiona Edith Harrison
• 金额: $ 23.14万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10229596
• 关键词: Address; Adopted; Affect; Animal Model; Animal Testing; Animals; Area; Basic Science; Behavior assessment; Behavioral; Caregivers; Clinical; Clinical assessments; Communities; Complement; Complex; Computer software; Consultations; Data; Data Analyses; Data Collection; Data Science Core; Development; Disease; Down Syndrome; Encapsulated; Equipment; Experimental Designs; Family; Fee-for-Service Plans; Funding; Generations; Goals; Grant; Home; Human; Individual; Infrastructure; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Intervention; Laboratories; Language; Manuscripts; Measurement; Measures; Methods; Modeling; Outcome; Output; Phenotype; Physiological; Population; Population Research; Precision therapeutics; Protocols documentation; Quality of life; Reproducibility; Research; Research Personnel; Research Training; Resources; Rodent; Rodent Model; Services; Testing; Training; Training Support; Translating; Translational Research; Vulnerable Populations; Work; animal data; autism spectrum disorder; base; behavior observation; behavioral phenotyping; community involvement; data integration; design; disability; equipment training; experience; home test; human data; human model; improved; individualized medicine; innovation; instrumentation; investigator training; laboratory experience; large datasets; mouse model; new technology; novel; novel strategies; phenotypic data; pre-clinical; predictive marker; public health relevance; response; success; targeted treatment; testing services; tool; translational neuroscience; wearable device

The Behavioral Phenotyping Core (Core D) is designed to support three overarching aims: To support and promote innovative and replicable behavioral phenotyping data in clinical populations people with IDD (Aim 1) and in rodent models of IDD (Aim 2); and to facilitate translational research incorporating human and animal data approaches (Aim 3). Previously supported iterations of this Core have been highly generative in terms of grant submission and manuscript support. The guiding thematic focus of the newly designed Core supports the “non-traditional” emphasis articulated for the overarching goals of the IDDRC in incorporating non-traditional researchers, non-traditional populations, and non-traditional approaches into every facet of the core. The Core will accomplish these goals by providing six major services: (i) Consultation. The three Co-Directors (Peters, Harrison, Wallace) have complementary expertise in human and animal phenotyping including specific experience with project design and analysis approaches. Consultation services will serve to support rigorous experimental design by IDD researchers and, importantly, support non-IDD researchers who wish to develop IDD-relevant projects despite lack of previous experience (non-traditional researchers). Consultation services are supported by comprehensive (ii) training for Core users. Training includes hands-on support for equipment use (animal and human research) and clinical assessment training. A new focus of the Core is to support the use of wearable devices and the use of apps for in-home behavioral observation in order to provide the opportunity for non-traditional populations to participate in research. Training will therefore also extend to non-scientist care-givers for in-home testing. Key to the Core’s success in prior funding periods has been the ability to provide (iii) access to equipment and facilities. State-of-the-art facilities and equipment for human and animal testing will continue to be supported for IDD researchers to use on a discounted fee-for-service basis. (iv) Full-service phenotyping is now offered for both human and animal testing conducted by trained research technicians. This service will permit non-traditional researchers to perform IDD-related research regardless of IDD-related experience, increase testing throughput, particularly for smaller laboratories, and support experimental rigor. The Core will continue to offer (v) scientific Instrumentation fabrication services for specialized equipment for human and animal projects. The final service (vi) data integration and conceptual development is designed as a complement to consultation service for basic science investigators who wish expand their work into human clinical populations, as well as for clinically-oriented investigators wishing to expand into animal models. This truly translational service will enable similar methods and models to be utilized or adapted across species to directly measure phenotypically relevant outcomes including behavioral and physiological measures, therefore encapsulating the IDDRC’s overarching goal to accelerate discovery in IDD research through trans-disciplinary approaches.

行为表型核心（核心D）旨在支持三个首要目标：支持和 在临床人群中推广创新和可复制的行为表型数据（目标1） 和IDD的啮齿动物模型（目标2）;并促进包括人类和动物的转化研究 数据方法（目标3）。以前支持的这个核心的迭代在以下方面具有很高的生成性： 资助投稿和稿件支持。新设计的核心文件的指导性专题重点支持 为非洲工发十年的总体目标阐明了"非传统"重点， 研究人员、非传统人口和非传统方法进入核心的每一个方面。核心 将通过提供六项主要服务来实现这些目标：（一）咨询。三位联合董事（彼得斯， Harrison，Wallace）在人类和动物表型分析方面具有互补的专业知识，包括特异性 具有项目设计和分析方法的经验。咨询服务将有助于支持严格的 IDD研究人员的实验设计，重要的是，支持希望开发的非IDD研究人员 缺乏经验的缺碘症相关项目（非传统研究人员）。咨询服务 通过对核心用户的全面（ii）培训提供支持。培训包括以下方面的实际支持 设备使用（动物和人体研究）和临床评估培训。核心的一个新重点是 支持使用可穿戴设备和应用程序进行家庭行为观察，以提供 非传统人群参与研究的机会。因此，培训还将扩大到 非科学家护理人员进行家庭测试。核心方案在以往供资期间取得成功的关键是， （三）提供设备和设施的能力。为人类提供最先进的设施和设备 将继续支持IDD研究人员使用动物试验， 基础(iv)全方位的表型分析服务现在提供给人类和动物试验， 研究技术人员。这项服务将允许非传统研究人员进行与缺碘症有关的研究 无论有无缺碘症相关经验，都能提高检测通量，特别是对小型实验室而言， 支持严格的实验。核心将继续提供（v）科学仪器制造服务 用于人类和动物项目的专用设备。最终服务（六）数据集成和 概念发展是对基础科学研究者咨询服务的补充 希望将其工作扩展到人类临床人群以及面向临床的研究人员 希望扩展到动物模型。这种真正的翻译服务将使类似的方法和模型 用于或适用于跨物种，以直接测量表型相关结果，包括 行为和生理措施，因此封装IDDRC的首要目标，以加速 通过跨学科的方法在IDD研究中发现。