Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt

成立于1965年，是最早的智力和发育障碍研究中心之一 (IDDRC)，范德比尔特肯尼迪中心(VKC)IDDRC是范德比尔特的中心纽带 智力和发育障碍(IDD)方面的跨学科研究、交流和培训。这个 VKC IDDRC是一个跨机构的机构，汇集了来自38个系的200多名教职员工 在范德比尔特的10所学校。VKC的使命是促进发现，为改进最佳实践提供信息 IDD患者及其家人的生活。这一使命是通过利用我们杰出的机构来实现的 资源和支助，与残疾人社区结成伙伴关系，利用协同互动 在VKC的联邦指定中心：VKC IDDRC，位于 发育障碍和神经发育障碍领导力教育计划。这个 IDDRC作为VKC的核心，是创造“中心文化”的基础性组织结构 其中研究和发现渗透到VKC更广泛的培训和服务活动中，从而增强 IDDRC的翻译研究目标。IDDRC取得的显著成功包括976名调查员- 撰写的出版物和NIH向Vanderbilt提供的强劲资金，以支持与IDD相关的研究(20财年为5260万美元)。 利用和利用这一跨机构的力量，专注于IDD的独特挑战， IDDRC下一阶段的总体目标是发展对IDD的精准护理，通过提供 基础设施和科学领先地位，使基本发现能够快速转化为高 影响碘缺乏病干预和治疗。三个全球目标指导着国际发展与发展中心的工作。AIM 1提供核心 支持和传播基于病因的个体化治疗的有效研究的服务， 机制，并导致缺乏症的共病后遗症；目标2侧重于纳入创新方法 和加强多学科IDD研究的方法；目标3建议进行签名 旨在提高自闭症患者抗精神病药物使用精确度的研究项目。穿过这些 AIMS和IDDRC支持的五个核心(行政、临床翻译、翻译 神经科学、行为表型和数据科学)，三个主题渗透到我们的工作中：(1)招聘 目前没有进行IDD研究的高技能研究人员(非传统研究人员)；(2)纳入 参加目前不包括IDD(非传统对象)的研究的IDD参与者；以及(3) 采用新的科学途径和方法(非传统方法)。我们的IDDRC是理想的 通过支持50名研究人员领导70名研究人员，实现快速发现精准护理方法 研究项目(15个来自NICHD)，并如签名研究项目所强调的那样，促进和 实施生成性、新颖性和影响力的研究方向，从而满足NICHD的应用愿景 新发展的技术和方法，以迅速加快预防和/或改善IDDS。

Founded in 1965 as one of the original Intellectual and Developmental Disorders Research Centers (IDDRC), the Vanderbilt Kennedy Center (VKC) IDDRC serves as the central nexus across Vanderbilt for interdisciplinary research, communication, and training in intellectual and developmental disabilities (IDD). The VKC IDDRC serves as a trans-institutional institute that brings together over 200 faculty from 38 departments in 10 schools at Vanderbilt. The VKC’s mission to facilitate discoveries that inform best practices to improve the lives of people with IDD and their families. This mission is met by leveraging our outstanding institutional resources and support, partnering with disability communities, and capitalizing on synergistic interactions across the VKC’s federally-designated centers: the VKC IDDRC, a University Center of Excellence in Developmental Disabilities and a Leadership Education in Neurodevelopmental Disabilities program. The IDDRC as the centerpiece of the VKC is the foundational organizing structure that creates a “Center culture” wherein research and discovery permeates the VKC’s broader training and service activities, thus enhancing the translational research goals of the IDDRC. Demonstrable IDDRC success includes 976 investigator- authored publications and robust NIH funding to Vanderbilt to support IDD-related research ($52.6M in FY20). Harnessing and leveraging this trans-institutional strength to focus on unique challenges in IDD, the overarching goal of the next phase of the IDDRC is to develop precision care for IDD by providing infrastructure and scientific leadership to enable rapid translation of basic discoveries into high- impact IDD interventions and treatments. Three global Aims guide the IDDRC’s work. Aim 1 provides core services to enable and disseminate impactful research on individualizing treatments based upon the causes, mechanisms, and contributing co-morbid sequelae of IDD; Aim 2 focuses on incorporating innovative methods and approaches to enhance multidisciplinary IDD research; and Aim 3 proposes to conduct a signature research project to improve the precision use of antipsychotic medication in people with autism. Across these Aims and five Cores supported by the IDDRC (Administrative, Clinical Translational, Translational Neuroscience, Behavioral Phenotyping, and Data Sciences), three themes permeate our work: (1) recruitment of highly-skilled researchers not currently conducting IDD research (non-traditional researchers); (2) inclusion of IDD participants into research studies that currently do not include IDD (non-traditional subjects); and (3) incorporation of novel scientific approaches and methods (non-traditional approaches). Our IDDRC is ideally posed to enable rapid discovery of precision care approaches by supporting 50 investigators leading 70 research projects (15 from NICHD) and, as highlighted by the Signature Research Project, to promote and implement generative, novel, and impactful research directions, thus meeting the NICHD’s vision of applying newly evolved technologies and approaches to rapidly accelerate the prevention and/or amelioration of IDDs.