Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at Vanderbilt

总体而言：范德堡大学尤尼斯·肯尼迪·施赖弗智力与发育障碍研究中心

• 批准号: 10685984
• 负责人: Jeffrey L Neul
• 金额: $ 135.8万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-06 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685984
• 关键词: Academic Medical Centers; Acceleration; Affect; Antipsychotic Agents; Basic Science; Behavioral; Biomedical Research; Caregivers; Caring; Clinical Research; Clinical Trials; Communication; Communities; Computerized Medical Record; Data; Data Science; Development; Developmental Disabilities; Diagnosis; Disease; Disease model; Down Syndrome; Education; Evaluation; Faculty; Family; Foundations; Funding; Future; Genotype; Goals; Image; Individual; Infrastructure; Institution; Intellectual and Developmental Disabilities Research Centers; Intellectual functioning disability; Interdisciplinary Study; Intervention; Leadership; Longevity; Machine Learning; Medical Records; Methods; Mission; Modeling; National Institute of Child Health and Human Development; Neurodevelopmental Disability; Obesity; Outcome; Participant; Persons; Pharmaceutical Preparations; Pharmacogenetics; Phase; Pilot Projects; Policy Research; Prevention; Problem behavior; Publications; Research; Research Personnel; Research Project Grants; Resources; Risk; Sampling; Schools; Series; Services; Techniques; Technology; Testing; Training; Translational Research; Translations; United States National Institutes of Health; Universities; Vision; Weight Gain; Work; autism spectrum disorder; behavioral phenotyping; clinical translation; comorbidity; cost effective; developmental disease; disability; drug-induced weight gain; experience; image processing; implementation science; improved; individualized medicine; individuals with autism spectrum disorder; innovation; large datasets; lectures; meetings; multidisciplinary; novel; organizational structure; personalized approach; personalized care; personalized medicine; population based; pragmatic trial; predictive modeling; programs; public health relevance; recruit; research study; skills; success; targeted treatment; translational neuroscience; trial comparing

Founded in 1965 as one of the original Intellectual and Developmental Disorders Research Centers (IDDRC), the Vanderbilt Kennedy Center (VKC) IDDRC serves as the central nexus across Vanderbilt for interdisciplinary research, communication, and training in intellectual and developmental disabilities (IDD). The VKC IDDRC serves as a trans-institutional institute that brings together over 200 faculty from 38 departments in 10 schools at Vanderbilt. The VKC’s mission to facilitate discoveries that inform best practices to improve the lives of people with IDD and their families. This mission is met by leveraging our outstanding institutional resources and support, partnering with disability communities, and capitalizing on synergistic interactions across the VKC’s federally-designated centers: the VKC IDDRC, a University Center of Excellence in Developmental Disabilities and a Leadership Education in Neurodevelopmental Disabilities program. The IDDRC as the centerpiece of the VKC is the foundational organizing structure that creates a “Center culture” wherein research and discovery permeates the VKC’s broader training and service activities, thus enhancing the translational research goals of the IDDRC. Demonstrable IDDRC success includes 976 investigator- authored publications and robust NIH funding to Vanderbilt to support IDD-related research ($52.6M in FY20). Harnessing and leveraging this trans-institutional strength to focus on unique challenges in IDD, the overarching goal of the next phase of the IDDRC is to develop precision care for IDD by providing infrastructure and scientific leadership to enable rapid translation of basic discoveries into high- impact IDD interventions and treatments. Three global Aims guide the IDDRC’s work. Aim 1 provides core services to enable and disseminate impactful research on individualizing treatments based upon the causes, mechanisms, and contributing co-morbid sequelae of IDD; Aim 2 focuses on incorporating innovative methods and approaches to enhance multidisciplinary IDD research; and Aim 3 proposes to conduct a signature research project to improve the precision use of antipsychotic medication in people with autism. Across these Aims and five Cores supported by the IDDRC (Administrative, Clinical Translational, Translational Neuroscience, Behavioral Phenotyping, and Data Sciences), three themes permeate our work: (1) recruitment of highly-skilled researchers not currently conducting IDD research (non-traditional researchers); (2) inclusion of IDD participants into research studies that currently do not include IDD (non-traditional subjects); and (3) incorporation of novel scientific approaches and methods (non-traditional approaches). Our IDDRC is ideally posed to enable rapid discovery of precision care approaches by supporting 50 investigators leading 70 research projects (15 from NICHD) and, as highlighted by the Signature Research Project, to promote and implement generative, novel, and impactful research directions, thus meeting the NICHD’s vision of applying newly evolved technologies and approaches to rapidly accelerate the prevention and/or amelioration of IDDs.

成立于1965年，是最初的智力和发育障碍研究中心之一。 （IDDRC），范德比尔特肯尼迪中心（VKC）IDDRC作为整个范德比尔特的中心纽带， 在智力和发育障碍（IDD）方面的跨学科研究、交流和培训。的 VKC IDDRC是一个跨机构的研究所，汇集了来自38个部门的200多名教师 范德比尔特的10所学校。VKC的使命是促进发现，为最佳实践提供信息， IDD患者及其家人的生活。这一使命是通过利用我们出色的机构 资源和支持，与残疾人社区合作，利用协同互动 在VKC的联邦指定的中心：VKC IDDRC，卓越的大学中心， 发展性残疾和神经发展性残疾计划的领导力教育。的 IDDRC作为VKC的核心，是创建“中心文化”的基本组织结构 其中研究和发现渗透到VKC更广泛的培训和服务活动中，从而提高 IDDRC的翻译研究目标。可证明的IDDRC成功包括976名调查员- 撰写出版物，并向范德比尔特提供强大的NIH资金，以支持IDD相关研究（2020财年为5260万美元）。 利用和利用这一跨机构的力量，集中应对缺碘症方面的独特挑战， IDDRC下一阶段的总体目标是通过提供以下服务来发展对IDD的精确护理 基础设施和科学领导力，使基本发现能够迅速转化为高质量的产品， 影响缺碘症干预和治疗。非洲工发十年的工作以三个全球目标为指导。Aim 1提供核心 提供服务，以促进和传播关于基于病因的个性化治疗的有影响力的研究， 目标2侧重于采用创新方法， 目标3建议开展一项签署 研究项目，以提高抗精神病药物在自闭症患者中的精确使用。跨这些 IDDRC支持的目标和五个核心（行政、临床翻译、翻译 神经科学、行为表型分析和数据科学），三个主题贯穿我们的工作：（1）招募 目前没有从事碘缺乏病研究的高技能研究人员（非传统研究人员）;（2）纳入 （3）参与现时不包括缺碘症的研究（非传统科目）;及 采用新的科学办法和方法（非传统办法）。我们的IDDRC是理想的 通过支持50名研究人员领导70名研究人员， 研究项目（15个来自NICHD），并强调了签名研究项目，以促进和 实施生成性，新颖性和有影响力的研究方向，从而满足NICHD的应用愿景 迅速加速预防和/或改善缺碘症的新技术和方法。

项目成果

Anatomical texture patterns identify cerebellar distinctions between essential tremor and Parkinson's disease.

解剖学纹理模式鉴定了基本震颤与帕金森氏病之间的小脑区分。

• DOI: 10.1002/hbm.25331
• 发表时间: 2021-06-01
• 期刊: Human brain mapping
• 影响因子: 4.8
• 作者: Hett K;Lyu I;Trujillo P;Lopez AM;Aumann M;Larson KE;Hedera P;Dawant B;Landman BA;Claassen DO;Oguz I
• 通讯作者: Oguz I

Laws Forbidding Pregnancy Discrimination in Substance Use Disorder Treatment Are Not Associated With Treatment Access.

在药物使用障碍治疗中禁止怀孕歧视的法律与治疗获取无关。

• DOI: 10.1097/adm.0000000000000897
• 发表时间: 2022-05-01
• 期刊: Journal of addiction medicine
• 影响因子: 5.5
• 作者: Davis CS;McNeer E;Patrick SW
• 通讯作者: Patrick SW

Disruption of Synaptic Transmission in the Bed Nucleus of the Stria Terminalis Reduces Seizure-Induced Death in DBA/1 Mice and Alters Brainstem E/I Balance.

• DOI: 10.1177/17590914221103188
• 发表时间: 2022-01
• 期刊: ASN NEURO
• 影响因子: 4.7
• 作者: Xia, Maya;Owen, Benjamin;Chiang, Jeremy;Levitt, Alyssa;Preisinger, Katherine;Yan, Wen Wei;Huffman, Ragan;Nobis, William P.
• 通讯作者: Nobis, William P.

Cataloguing and characterizing interests in typically developing toddlers and toddlers who develop ASD.

• DOI: 10.1002/aur.2543
• 发表时间: 2021-08
• 期刊: Autism research : official journal of the International Society for Autism Research
• 作者: Burrows CA;Bodfish JW;Wolff JJ;Vollman EP;Altschuler MR;Botteron KN;Dager SR;Estes AM;Hazlett HC;Pruett JR Jr;Schultz RT;Zwaigenbaum L;Piven J;Elison JT;IBIS Network
• 通讯作者: IBIS Network

Cyclooxygenase-2 inhibition prevents stress induced amygdala activation and anxiety-like behavior.

• DOI: 10.1016/j.bbi.2020.07.046
• 发表时间: 2020-10
• 期刊: Brain, behavior, and immunity
• 作者: Morgan A;Gaulden A;Altemus M;Williford K;Centanni S;Winder D;Patel S
• 通讯作者: Patel S