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Core B: Clinical Translational Core

核心 B：临床转化核心

基本信息

批准号：
10229593
负责人：
BETH A MALOW
金额：
$ 20.89万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10229593
关键词：
Address Affect Area Asthma Behavior assessment Blood Caregivers Child Clinical Clinical Research Clinical Trials Consent Consultations Data Data Analyses Data Science Core Discipline Disease Down Syndrome Educational Intervention Educational Materials Electronic Health Record Enrollment Face Family Feedback Future Genetic Databases Healthcare Systems Individual Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Intervention Studies Learning Longevity Maintenance Medical Methods Modeling Obesity Outcome Participant Patients Population Population Study Pragmatic clinical trial Preparation Prevalence Protocols documentation Registries Research Research Design Research Personnel Research Project Grants Resources Rural Population Scanning Schools Services Structure System Technology Testing Time Training Translating Translational Research Work aging population autism spectrum disorder base behavioral phenotyping community engagement design disability driving force efficacy evaluation electronic consent electronic data imaging modality improved individualized medicine innovation neurophysiology novel novel strategies pragmatic trial public health relevance recruit remote intervention research study response retention rate targeted treatment telehealth tool translational neuroscience translational study vaccine trial

项目摘要

The Clinical Translational Core B will: (1) enable intellectual and developmental disabilities (IDD)-related clinical research to accelerate translational studies of the causes, associated clinical features, and new interventions in IDD; (2) incorporate non-traditional approaches into IDD research, including pragmatic clinical trials within learning healthcare systems and remote interventional studies and (3) enhance inclusion of IDD populations into ongoing (non-IDD) research studies by providing investigative teams with the necessary tools and trainings to support these populations. These efforts will facilitate inclusion of people with IDD into ongoing clinical and translational research, especially in studies from which they have previously been excluded. The Core’s services include (1) hands-on support to IDDRC research teams in the form of targeted consultations that tailor “condition-agnostic” Vanderbilt resources such as the Recruitment Innovation Center, which implements recruitment and retention strategies for clinical trials, to the needs of IDD populations; (2) maintenance and expansion of two research registries, one for autism spectrum disorder and one for Down syndrome; (3) consultation on data pulls for electronic health records and genetic databanks; (4) various methods to enable remote research, including online research portals and telehealth research approaches; and (5) hands-on support to non-IDD research teams to enhance inclusion in studies, including modifying Electronic Consent (eConsent) for IDD populations. These services are both responsive to investigator needs as well as generative in adding value to IDD research locally and nationwide, via dissemination through national networks. Overall, Core B’s services are focused on encouraging non-traditional researchers (e.g. those not working on IDD) to become engaged in IDD research; enables research involving non-traditional participants (e.g. people with IDD typically excluded from ongoing clinical research); and facilitates the use of non-traditional approaches (e.g. pragmatic trials, remote research) into IDD research efforts. Thus, Core B’s activities enable IDD research to be conducted optimally from study design to recruitment/consent, to implementation, and also expands efforts to more appropriately represent those with IDD in non-IDD ongoing research studies. Together these activities will accelerate IDD-related discoveries that will lead to high-impact interventions and treatments, thus improving the lives of those with IDD and families.

临床转化核心B将：(1)使智力和发育障碍（IDD）相关