Neurotechnology design features' impact on the identity and function of reactive astrocytes
Neurotechnology design features' impact on the identity and function of reactive astrocytes
批准号:
10229345
负责人:
Ti'Air Riggins
金额:
$3.71万
依托单位国家:
美国
项目类别:
财政年份:
2020
资助国家:
美国
项目状态:
已结题
起止时间:
2020-07-06 至 2022-01-31
关键词:
ActinsAddressAffectAstrocytesAtomic Force MicroscopyBasic ScienceBiological AssayBiological MarkersBoronBrainCalcium ChannelCellsChronicClinical TrialsCoculture TechniquesComplementComplexCyclic AMPDevicesDiamondDiseaseElectrodesEnvironmentFemaleForeign BodiesFutureGene ExpressionGeneticGenetic TranscriptionGlial Fibrillary Acidic ProteinGlutamatesGoalsHourHypertrophyImmune responseImmune systemImmunochemistryImplantImplanted ElectrodesInflammationInflammatoryInjuryInterdisciplinary StudyIon ChannelKnock-outKnowledgeLipopolysaccharidesLiteratureLongevityMeasuresMechanicsMeningealMetabolismMethodsMicroelectrodesModelingMolecularMonitorMorphologyMotor CortexNerve DegenerationNeurodegenerative DisordersNeuronal PlasticityNeuronsNeurosciencesNoisePathway interactionsPatientsPerformancePhasePlayProductionProtein IsoformsQuadriplegiaReactive Oxygen SpeciesReportingResearchResearch PersonnelRoboticsRoleSelf-Help DevicesSignal TransductionSiliconSiteStimulusSuperoxide DismutaseSurfaceTechniquesTherapeutic Human ExperimentationTimeTissuesTrainingWorkarmastrogliosiscareercytokinedesignimplantationimprovedknock-downmechanical devicemechanical propertiesmigrationneurotechnologyneurotoxicnext generation sequencingpatch clamppotential biomarkerpre-doctoralpreventprotein expressionresponseskillstargeted treatmenttherapeutic targettranscriptometranscriptome sequencingwound
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
Implantable neurotechnology such as microelectrode arrays offers substantial promise to improve
the condition of many neurogenerative diseases. However, shortly after implantation, foreign body
response occurs, which is what researchers believe decreases stability and longevity of these
devices. Established biomarkers such as glial acid fibrillary protein and astrogliosis and stimuli such
as mechanical mismatch are studied to assess the state of response to the devices, however
immune response in the brain is not well understood. Astrocytes play an important role in the
brain’s immune system and recently, transcriptome analysis has confirmed calcium channel activity
of reactive astrocytes to be a potential biomarker in many neurodegenerative diseases, in this
dissertation project, I will investigate the correlation between astroglial reactivity and device
features. Preliminary studies have demonstrated that calcium channel isoforms respond to different
stimuli to induce the reactive state. I will use tissue co-culture methods to induce three types of
inflammatory astrocytic models, and characterize each model’s reactivity to probe material stiffness,
device features and change in cytoarchitecture, metabolism and pathophysiological genetic
expression. I aim to elucidate that pathway in neuro foreign body response, which will give
researchers a potential biomarker to target for therapeutic research concerning implantable
neurotechnology. I have outlined the work done thus far, current and future training strategies for
academic, professional, and educational advancement, as it relates to this project and aligns with
this my career goals.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
Atomic Force Microscope Characterization of the Bending Stiffness and Surface Topography of Silicon and Polymeric Electrodes.
硅和聚合物电极的弯曲刚度和表面形貌的原子力显微镜表征。
DOI:
10.1109/embc48229.2022.9871216
发表时间:
2022
期刊:
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
影响因子:
--
作者:
[Riggins,Ti'AirE, Li,Wen, Purcell,ErinK]
通讯作者:
Purcell,ErinK
Toward a Three-Dimensional Brian Organoid Model to Evaluate Neuro Technology Device
-
批准号:10558011
-
项目类别:
-
资助金额:$7.62万
-
财政年份:2022
-
负责人:Ti'Air Riggins
-
依托单位:
海外基金