UNC Integrated Translational Oncology Program (UNC-iTOP)

摘要 位于查佩尔山的北卡罗来纳州大学综合转化肿瘤学项目（UNC-iTOP）是一个 T32培训计划侧重于培训临床医生（MD），基础科学家（PhD）和博士，MD和MD-PhD 候选人在临床/转化疾病为基础的研究在临床肿瘤学和癌症的接口 使用病人样本的生物学。我们招募了具有广泛兴趣的导师/教师，他们致力于 改善转化肿瘤学和基于组织的研究。由两名医生和科学家领导， 在基于组织的研究、临床适用的临床前模型和临床试验方面的互补专业知识， 联合国大学国际培训方案招聘了在各自领域具有领导地位的教员/教员。UNC-iTOP教师包括 成员具有专注于癌症生物标志物和新型疗法的转化研究的专业知识， 对患者的干预。所有UNC-iTOP教师都批准了IRB方案，并领导了前瞻性临床研究。 方案和/或试验。 对联合国内罗毕办事处国际办事处的支助将有助于积极、有力和持续地努力查明、征聘和培训 有前途的医学博士，博士，和MD-PhD研究人员的研究生涯，将解决知识差距， 组织转化肿瘤学研究。基于组织的转化肿瘤学研究一直是 这对于识别癌症起始、进展和转移的关键驱动因素是重要的。识别 针对每个阶段的脆弱性的治疗仍然是一个广泛的需要领域。评估新 具有更严格指标的相关模型中的治疗是将发现转化为临床的关键。验证 在患者中的发现是首要目标。要想在每个领域取得成功，都需要对以下方面有基本的了解： 支持尖端研究的医疗保健和临床协议/监管系统的运作。 UNC-iTOP将为致力于翻译的MD和PhD学员提供全面的培训计划 肿瘤学和组织研究。我们认识到，转化肿瘤学研究涉及许多 学科和成功的进步是跨学科团队的结果。UNC-iTOP侧重于 早期整合“基础”、“临床”和“监管”团队，总体目标是培养一支骨干队伍， 翻译科学家（包括医学博士和博士），他们将成为该领域的下一代领导者。 肿瘤学研究

Abstract The University of North Carolina at Chapel Hill Integrated Translational Oncology Program (UNC-iTOP) is a T32 training program focused on training clinicians (MDs), basic scientists (PhDs), and PhD, MD and MD-PhD candidates in clinical/translational disease based research at the interface of clinical oncology and cancer biology using patient samples. We have recruited preceptors/faculty with broad interests who are committed to improving translational oncology and tissue-based research. Led by two physician-scientists with complementary expertise in tissue-based research, clinically applicable preclinical models, and clinical trials, UNC-iTOP has recruited preceptors/faculty who are leaders in their fields. The UNC-iTOP faculty includes members with expertise in translational research focusing on biomarkers of cancer and novel therapies and interventions for patients. All UNC-iTOP faculty have approved IRB protocols and have led prospective clinical protocols and/or trials. Support for UNC-iTOP will enable a proactive, energetic and sustained effort to identify, recruit and train promising MD, PhD, and MD-PhD investigators for research careers that will address the knowledge gap in tissue-based translational oncology research. Translational oncology tissue-based research has been critically important for the identification of key drivers of cancer initiation, progression and metastasis. Identifying treatments that target the vulnerabilities at each stage continues to be a broad area of need. Evaluating new therapies in relevant models with more stringent metrics is key to translating findings to the clinic. Validating findings in patients is the overarching goal. To succeed in each area requires a fundamental understanding of the workings of the healthcare and clinical protocol/regulatory system that supports cutting edge research. UNC-iTOP will provide a comprehensive training program for MD and PhD trainees committed to translational oncology and tissue-based research. We recognize that translational oncology research involves numerous disciplines and successful advances are the result of interdisciplinary teams. The UNC-iTOP focuses on integrating the “basic”, “clinical”, and “regulatory” teams early on with the overarching goal to develop a cadre of translational scientists (both MDs and PhDs) who will be the next generation of leaders in the field of oncology research.