UNC Integrated Translational Oncology Program (UNC-iTOP)

摘要 北卡罗来纳大学教堂山分校综合转化肿瘤学项目(UNC-iTOP)是 T32培训计划侧重于培训临床医生(MD)、基础科学家(PhD)以及博士、MD和MD-PhD 临床肿瘤学与癌症交界处基于临床/转化性疾病研究的候选人 使用病人样本的生物学。我们招募了具有广泛兴趣的导师/教职员工，他们致力于 改进转化肿瘤学和基于组织的研究。由两位内科科学家领导， 在基于组织的研究、临床适用的临床前模型和临床试验方面的互补专业知识， UNC-iTOP已经招募了各自领域的领导者/教员。UNC-iTOP的教职员工包括 具有专注于癌症生物标记物和新疗法的翻译研究专业知识的成员 对患者的干预。所有UNC-iTOP教员都批准了IRB方案，并领导了未来的临床 方案和/或试验。 对UNC-iTOP的支持将有助于积极、积极和持续的努力，以确定、招募和培训 有希望的MD、博士和MD-PhD研究人员的研究生涯将解决知识差距 基于组织的转译肿瘤学研究。翻译肿瘤学基于组织的研究一直是至关重要的 对于确定癌症发生、发展和转移的关键驱动因素非常重要。识别 在每个阶段针对脆弱性的治疗仍然是一个广泛的需要领域。评估新产品 相关模型中的治疗方法具有更严格的指标，是将研究结果转化为临床的关键。正在验证 在患者身上的发现是最重要的目标。要在每个领域取得成功，需要对以下方面有基本的了解 支持尖端研究的医疗保健和临床方案/监管系统的工作方式。 UNC-iTOP将为致力于翻译的医学博士和博士学员提供全面的培训计划 肿瘤学和组织研究。我们认识到转译肿瘤学研究涉及到许多 学科和成功的进步是跨学科团队的结果。UNC-iTOP的重点是 早期整合“基础”、“临床”和“监管”团队，以培养一支干部队伍为总目标 翻译科学家(包括医学博士和博士)，他们将成为该领域的下一代领导者 肿瘤学研究。

Abstract The University of North Carolina at Chapel Hill Integrated Translational Oncology Program (UNC-iTOP) is a T32 training program focused on training clinicians (MDs), basic scientists (PhDs), and PhD, MD and MD-PhD candidates in clinical/translational disease based research at the interface of clinical oncology and cancer biology using patient samples. We have recruited preceptors/faculty with broad interests who are committed to improving translational oncology and tissue-based research. Led by two physician-scientists with complementary expertise in tissue-based research, clinically applicable preclinical models, and clinical trials, UNC-iTOP has recruited preceptors/faculty who are leaders in their fields. The UNC-iTOP faculty includes members with expertise in translational research focusing on biomarkers of cancer and novel therapies and interventions for patients. All UNC-iTOP faculty have approved IRB protocols and have led prospective clinical protocols and/or trials. Support for UNC-iTOP will enable a proactive, energetic and sustained effort to identify, recruit and train promising MD, PhD, and MD-PhD investigators for research careers that will address the knowledge gap in tissue-based translational oncology research. Translational oncology tissue-based research has been critically important for the identification of key drivers of cancer initiation, progression and metastasis. Identifying treatments that target the vulnerabilities at each stage continues to be a broad area of need. Evaluating new therapies in relevant models with more stringent metrics is key to translating findings to the clinic. Validating findings in patients is the overarching goal. To succeed in each area requires a fundamental understanding of the workings of the healthcare and clinical protocol/regulatory system that supports cutting edge research. UNC-iTOP will provide a comprehensive training program for MD and PhD trainees committed to translational oncology and tissue-based research. We recognize that translational oncology research involves numerous disciplines and successful advances are the result of interdisciplinary teams. The UNC-iTOP focuses on integrating the “basic”, “clinical”, and “regulatory” teams early on with the overarching goal to develop a cadre of translational scientists (both MDs and PhDs) who will be the next generation of leaders in the field of oncology research.