UNC Integrated Translational Oncology Program (UNC-iTOP)

北卡罗来纳大学综合转化肿瘤学项目 (UNC-iTOP)

• 批准号: 10468679
• 负责人: WILLIAM Y. KIM
• 金额: $ 54.11万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-20 至 2024-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10468679
• 关键词: oncology program; translational oncology

Abstract The University of North Carolina at Chapel Hill Integrated Translational Oncology Program (UNC-iTOP) is a T32 training program focused on training clinicians (MDs), basic scientists (PhDs), and PhD, MD and MD-PhD candidates in clinical/translational disease based research at the interface of clinical oncology and cancer biology using patient samples. We have recruited preceptors/faculty with broad interests who are committed to improving translational oncology and tissue-based research. Led by two physician-scientists with complementary expertise in tissue-based research, clinically applicable preclinical models, and clinical trials, UNC-iTOP has recruited preceptors/faculty who are leaders in their fields. The UNC-iTOP faculty includes members with expertise in translational research focusing on biomarkers of cancer and novel therapies and interventions for patients. All UNC-iTOP faculty have approved IRB protocols and have led prospective clinical protocols and/or trials. Support for UNC-iTOP will enable a proactive, energetic and sustained effort to identify, recruit and train promising MD, PhD, and MD-PhD investigators for research careers that will address the knowledge gap in tissue-based translational oncology research. Translational oncology tissue-based research has been critically important for the identification of key drivers of cancer initiation, progression and metastasis. Identifying treatments that target the vulnerabilities at each stage continues to be a broad area of need. Evaluating new therapies in relevant models with more stringent metrics is key to translating findings to the clinic. Validating findings in patients is the overarching goal. To succeed in each area requires a fundamental understanding of the workings of the healthcare and clinical protocol/regulatory system that supports cutting edge research. UNC-iTOP will provide a comprehensive training program for MD and PhD trainees committed to translational oncology and tissue-based research. We recognize that translational oncology research involves numerous disciplines and successful advances are the result of interdisciplinary teams. The UNC-iTOP focuses on integrating the “basic”, “clinical”, and “regulatory” teams early on with the overarching goal to develop a cadre of translational scientists (both MDs and PhDs) who will be the next generation of leaders in the field of oncology research.

抽象的 北卡罗来纳大学教堂山综合翻译肿瘤学计划（UNC-ITOP）是一个 T32培训计划的重点是培训临床医生（MDS），基础科学家（PHD）和PhD，MD和MD-PHD 基于临床/转化疾病的候选者在临床肿瘤学和癌症界面的研究 使用患者样品的生物学。我们已经招募了具有广泛利益的主持人/教职员工，他们致力于 改善转化肿瘤学和基于组织的研究。由两个身体科学家领导 在基于组织的研究，临床适用的临床前模型和临床试验方面的完全专业知识， UNC-Itop招募了领导者/教职员工。 UNC-Itop教师包括 具有翻译研究专业知识的成员，重点是癌症和新型疗法的生物标志物以及 患者的干预措施。所有UNC-Itop教师均已批准IRB方案，并领导了前瞻性临床 协议和/或试验。 对UNC-Itop的支持将使能够积极，充满活力和持续的努力来识别，招募和培训 有希望的医学博士，博士和MD-PHD研究人员的研究职业将解决知识差距 基于组织的翻译肿瘤研究。基于翻译肿瘤组织的研究一直是至关重要的 对于鉴定癌症倡议，进展和转移的关键驱动因素而言至关重要。识别 针对每个阶段脆弱性的治疗仍然是广泛的需求领域。评估新 具有更严格指标的相关模型中的疗法是将发现转化为诊所的关键。验证 患者的发现是总体目标。要在每个领域取得成功，都需要对 支持尖端研究的医疗保健和临床方案/监管系统的运作。 UNC-Itop将为致力于翻译的医学博士和博士学位学员提供全面的培训计划 肿瘤学和基于组织的研究。我们认识到翻译肿瘤学研究涉及许多 学科和成功的进步是跨学科团队的结果。 UNC-Titop专注于 早期将“基本”，“临床”和“监管”团队与开发干部的总体目标相结合 翻译的科学家（MDS和PHD）将成为该领域的下一代领导者 肿瘤学研究。