UNC Oncology Clinical/Translational Research Training Program (OCT-RTP)

摘要 在这场竞争中，北卡罗来纳大学教堂山分校(UNC)成人分部 和儿科血液学/肿瘤学、放射肿瘤科和北卡罗来纳大学 莱恩伯格综合癌症中心(UNC LCCC)为UNC寻求新的资金 Calabresi K12，称为肿瘤学临床/转译研究培训计划(OCT- RTP)。所有的组成部分都将为培训计划提供导师和资源，以及 除LCCC外的所有组成部分都将提供学者。OCT-RTP将录取两名学者 每年。私人侦探诺曼·夏普莱斯博士是惠康癌症杰出教授 他是LCCC的研究部主任。夏普莱斯医生在肿瘤学方面有丰富的经验 翻译研究。汉娜·桑诺夫博士，医学副教授兼科长 GI医学肿瘤学，是一位经验丰富的导师，担任项目主任(PD) 在2016年。该计划的目标是建立一支训练有素的研究人员队伍， 将成为成功的、独立的癌症调查人员。可提供的培训资源 OCT-RTP包括：LCCC、北卡罗来纳州癌症医院和UNC临床和 支持教育、培训和职业的翻译科学奖(CTSA) 开发核心。OCT-RTP的目标是提高患者的质量和数量- 以癌症研究为导向。拟议的培训方案的基础将是 分配给每位学者的高素质基础科学和临床导师的参与 由K12领导层协调的指导活动。内部咨询委员会(IAC) 包括来自项目组成部分的资深教师将挑选和监督学者的进展， 而一个外部咨询委员会每年都会审查该计划。自成立以来，OCT- RTP已经招募了16名奖学金获得者，其中10名在上一个资助周期中获得资助，他们的记录是 进度报告中详细说明了这一点。自上次续签以来的主要变化包括新的PD(Dr。 Sanoff)，IAC组成的变化，与其他UNC培训的更大融合 计划，以及导师名册上的变化。特别是，导师花名册已被削减 从40名导师增加到34名导师，以增强研究重点，并增加了新的导师 更加多样化的现在相关的专业知识，包括患者报告的显著增加 结果、数据分析和新的临床试验设计。计划的设施和资源 已经演变为提供更强大的支持，包括利用相当大的国家 大学癌症研究基金(UCRF)的支持。我们相信这些变化和 增长加强了一个成功而重要的培训计划。

Abstract In this competing renewal, the University of North Carolina at Chapel Hill (UNC) Divisions of Adult and Pediatric Hematology/Oncology, the Department of Radiation Oncology and the UNC Lineberger Comprehensive Cancer Center (UNC LCCC) seek renewed funding for the UNC Calabresi K12, called the Oncology Clinical/Translational Research Training Program (OCT- RTP). All of the components will contribute mentors and resources to the training program, and all components except the LCCC will contribute scholars. The OCT-RTP will admit two scholars per year. The PI, Dr. Norman Sharpless, is the Wellcome Distinguished Professor in Cancer Research and Director of the LCCC. Dr. Sharpless has extensive experience in oncologic translational research. Dr. Hanna Sanoff, Associate Professor of Medicine and Section Chief of GI Medical Oncology, is an experienced mentor who assumed the role of Program Director (PD) in 2016. The program's objectives are to establish a rigorously trained cadre of researchers who will become successful, independent cancer investigators. Training resources available for the OCT-RTP include: the LCCC, the North Carolina Cancer Hospital and the UNC Clinical and Translational Science Award (CTSA) which supports an Education, Training, and Career Development Core. The goals of the OCT-RTP are to increase the quality and quantity of patient- oriented cancer research. The foundation of the proposed training program will be the participation of highly qualified basic science and clinical mentors assigned to each scholar with mentoring activities coordinated by the K12 leadership. An internal advisory committee (IAC) that includes senior faculty from the program components will select and monitor scholar progress, while an external advisory committee reviews the program annually. Since its inception, the OCT- RTP has enrolled sixteen Scholars, including 10 funded in the last grant cycle whose records are detailed in the progress report. Major changes since our last renewal include a new PD (Dr. Sanoff), changes in the composition of the IAC, greater integration with other UNC training programs, and changes in the mentorship roster. In particular, the mentor roster has been pruned from 40 to 34 mentors to enhance research focus, with the addition of new mentors adding a greater diversity of now-relevant expertise, including notable additions in patient-reported outcomes, data analytics and novel clinical trial design. Facilities and resources for the program have evolved to provide even stronger support, including the leveraging of considerable state support from the University Cancer Research Fund (UCRF). We believe these changes and growth have strengthened a successful and important training program.