UNC Oncology Clinical/Translational Research Training Program (OCT-RTP)

摘要 在这次竞争性更新中，北卡罗来纳大学教堂山分校 (UNC) 成人分部 和儿科血液学/肿瘤学、放射肿瘤学系和北卡罗来纳大学 莱恩伯格综合癌症中心 (UNC LCCC) 寻求为 UNC 提供新的资金 Calabresi K12，称为肿瘤学临床/转化研究培训计划 (OCT- 实时传输协议）。所有组成部分都将为培训计划提供导师和资源，并且 除 LCCC 外，所有组成部分都将贡献学者。 OCT-RTP将录取两名学者 每年。 PI Norman Sharpless 博士是 Wellcome 癌症领域杰出教授 LCCC 研究部主任。 Sharpless 博士在肿瘤学方面拥有丰富的经验 转化研究。 Hanna Sanoff 博士，医学副教授兼科长 GI医学肿瘤学，是一位经验丰富的导师，担任项目总监（PD） 2016 年。该计划的目标是建立一支经过严格培训的研究人员队伍， 将成为成功的、独立的癌症研究人员。可用的培训资源 OCT-RTP 包括：LCCC、北卡罗来纳州癌症医院和 UNC 临床与治疗中心 转化科学奖 (CTSA) 支持教育、培训和职业 开发核心。 OCT-RTP 的目标是提高患者治疗的质量和数量 定向癌症研究。拟议培训计划的基础将是 分配给每位学者的高素质基础科学和临床导师的参与 由 K12 领导层协调的指导活动。内部咨询委员会 (IAC) 包括项目组成部分的高级教师将选择和监控学者的进展， 外部咨询委员会每年都会对该计划进行审查。自成立以来，OCT RTP 已招收 16 名学者，其中 10 名是在上一个资助周期获得资助的，其记录为 进度报告中有详细说明。自上次更新以来的主要变化包括新的 PD（Dr. Sanoff），IAC 的组成发生变化，与 UNC 的其他培训进一步整合 计划以及导师名册的变化。特别是，导师名单被精简了 导师人数从 40 名增至 34 名，以增强研究重点，新导师的加入增加了 现在相关专业知识更加多样化，包括患者报告中的显着增加 结果、数据分析和新颖的临床试验设计。该计划的设施和资源 已经发展到提供更强有力的支持，包括利用相当大的国家力量 大学癌症研究基金（UCRF）的支持。我们相信这些变化和 增长加强了成功且重要的培训计划。

Abstract In this competing renewal, the University of North Carolina at Chapel Hill (UNC) Divisions of Adult and Pediatric Hematology/Oncology, the Department of Radiation Oncology and the UNC Lineberger Comprehensive Cancer Center (UNC LCCC) seek renewed funding for the UNC Calabresi K12, called the Oncology Clinical/Translational Research Training Program (OCT- RTP). All of the components will contribute mentors and resources to the training program, and all components except the LCCC will contribute scholars. The OCT-RTP will admit two scholars per year. The PI, Dr. Norman Sharpless, is the Wellcome Distinguished Professor in Cancer Research and Director of the LCCC. Dr. Sharpless has extensive experience in oncologic translational research. Dr. Hanna Sanoff, Associate Professor of Medicine and Section Chief of GI Medical Oncology, is an experienced mentor who assumed the role of Program Director (PD) in 2016. The program's objectives are to establish a rigorously trained cadre of researchers who will become successful, independent cancer investigators. Training resources available for the OCT-RTP include: the LCCC, the North Carolina Cancer Hospital and the UNC Clinical and Translational Science Award (CTSA) which supports an Education, Training, and Career Development Core. The goals of the OCT-RTP are to increase the quality and quantity of patient- oriented cancer research. The foundation of the proposed training program will be the participation of highly qualified basic science and clinical mentors assigned to each scholar with mentoring activities coordinated by the K12 leadership. An internal advisory committee (IAC) that includes senior faculty from the program components will select and monitor scholar progress, while an external advisory committee reviews the program annually. Since its inception, the OCT- RTP has enrolled sixteen Scholars, including 10 funded in the last grant cycle whose records are detailed in the progress report. Major changes since our last renewal include a new PD (Dr. Sanoff), changes in the composition of the IAC, greater integration with other UNC training programs, and changes in the mentorship roster. In particular, the mentor roster has been pruned from 40 to 34 mentors to enhance research focus, with the addition of new mentors adding a greater diversity of now-relevant expertise, including notable additions in patient-reported outcomes, data analytics and novel clinical trial design. Facilities and resources for the program have evolved to provide even stronger support, including the leveraging of considerable state support from the University Cancer Research Fund (UCRF). We believe these changes and growth have strengthened a successful and important training program.