Nonmydriatic ultra-widefield fundus photography employing trans-pars-planar illumination

R 01标题：采用跨部平面照明的非散瞳超宽视野眼底摄影 本计画旨在研制一种可携式全视网膜影像装置，并验证其对糖尿病视网膜病变的诊断价值 (DR)筛选和分类。糖尿病视网膜病变是糖尿病常见的并发症，是致盲的主要原因之一 糖尿病。及时筛查和早期诊断对于预防视力损害和失明至关重要。新兴 宽视野眼底照相在DR筛查、诊断和治疗中显示出其上级能力 评价然而，现有的宽视场眼底成像器的高成本和操作复杂性限制了其应用。 远程医疗DR检查的潜力，特别是在农村和服务不足的地区， 没有仪器和熟练的操作人员。我们最近已经证明了trans-pars的可行性- 平面照明，即，通过瞳孔外侧的睫状体平坦部传递照明光。通过释放 由于整个瞳孔仅用于成像目的，因此跨部分平面照明提供了发展的独特机会 一种低成本、便携式、非散瞳眼底照相机，具有超宽视野覆盖范围。使用所有现成的部件，我们 我已经展示了一种便携式接触式眼底照相机，在一张快照中可以覆盖200 °的视野 形象我们建议在这里追求定制设计的光学开发一个便携式，眼球接触自由230 o超， 宽视场眼底照相机（u-WFC）以在单个快照图像中覆盖整个视网膜。第一个目标是 项目是完善一个台式原型WFC定量表征睫状体平坦部的光学特性。 aim 1研究的预期结果是：1）确定不同的功率水平和暴露时间 色素沉着水平和年龄; 2）建立照明器的可调节距离/角度范围; 3）建立 真彩色眼底成像所需的R/G/B比值。这些数字将提供所有必要的信息， 详细介绍了目标2中所提出的便携式u-WFC的系统设计和规格。第二个目标是技术性的 开发便携式u-WFC。所提出的u-WFC可以作为低成本手持设备工作， 集成的跨面照明器或紧凑的台式仪器。原型U的初步测试- 将使用模型眼进行WFC。FOV、中央和周边空间分辨率将通过以下方式量化： 遵循ISO 10940：2009中定义的标准程序。第三个目标是便携式的临床验证 u-WFC。DR患者和健康受试者将在UIC Retina Clinic进行临床验证。为 功能比较，眼底图像将使用原型u-WFC，超宽场扫描激光采集 UIC眼科临床研究中心的眼底镜（SLO）和OCT血管造影（OCTA）。关键 本研究的成功标准是验证便携式230 o u-WFC可以提供可靠的DR检测 与200 ° Optos 200 Tx（Optos，马尔伯勒，MA）相比，

R01 title: Nonmydriatic ultra-widefield fundus photography employing trans-pars-planar illumination Summary: This project is to develop a portable pan-retinal imaging device, and validate it for diabetic retinopathy (DR) screening and classification. As a leading cause of blindness, DR is a frequent complication of diabetes mellitus. Prompt screening and early diagnosis is essential to prevent visual impairment and blindness. Emerging widefield fundus photography has demonstrated its superior capability in DR screening, diagnosis and treatment evaluation. However, the high cost and operational complexity of existing widefield fundus imagers limit its potential for telemedicine DR examination, particularly in rural and underserved areas where both expensive instruments and skilled operators are not available. We have recently demonstrated the feasibility of trans-pars- planar illumination, i.e., delivering illuminating light through the pars plana outside of the pupil. By freeing the whole pupil for imaging purpose only, the trans-pars-planar illumination provides a unique opportunity to develop a low-cost, portable, non-mydriatic fundus camera with ultra-widefield coverage. Using all off-the-shelf parts, we have demonstrated a portable, contact-mode fundus camera to cover 200o field of view in a single snapshot image. We propose here to pursue custom-designed optics to develop a portable, eyeball contact-free 230o ultra- widefield fundus camera (u-WFC) to cover the whole retina in a single snapshot image. The first aim of this project is to refine a benchtop prototype WFC to quantitatively characterize optical property of the pars plana. Anticipated outcomes of the aim 1 study are 1) to establish power levels and exposure time required for different pigmentation levels and ages; 2) to establish adjustable distance/angle range of the illuminator; 3) to establish R/G/B ratios required for true color fundus imaging. These numbers will provide all necessary information to detail the system design and specification of the proposed portable u-WFC in Aim 2. The second aim is technical development of a portable u-WFC. The proposed u-WFC can work as either a low-cost handheld device with integrated trans-pars-planar illuminator, or a compact benchtop instrument. Preliminary test of the prototype u- WFC will be conducted using a model eye. FOV, central and peripheral spatial resolutions will be quantified by following the standard procedures defined in ISO 10940:2009. The third aim is clinical validation of the portable u-WFC. DR patients and healthy subjects will be recruited for clinical validation at UIC Retina Clinic. For functional comparison, fundus images will be acquired using the prototype u-WFC, ultra-widefield scanning laser ophthalmoscope (SLO) and OCT angiography (OCTA) at UIC Clinical Research Center of Ophthalmology. Key success criterion of this study is to verify that the portable 230o u-WFC can provide reliable DR detection sensitivity and repeatability, compared to 200o Optos 200Tx (Optos, Marlborough, MA).