Nonmydriatic ultra-widefield fundus photography employing trans-pars-planar illumination

采用透明平面照明的免散瞳超广角眼底摄影

• 批准号: 9816977
• 负责人: Robison Vernon Paul Chan
• 金额: $ 56.08万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9816977
• 关键词: Age; Angiography; Area; Blindness; Cellular Phone; Classification; Clinic; Clinical; Clinical Research; Color; Complications of Diabetes Mellitus; Custom; Dependence; Detection; Development; Devices; Diabetes Mellitus; Diabetic Retinopathy; Diagnosis; Early Diagnosis; Evaluation; Eye; Eye diseases; Fostering; Fundus; Fundus photography; Image; Imaging Device; Investigation; Lasers; Light; Lighting; Location; Medical Device; Modeling; Mydriasis; Ophthalmology; Ophthalmoscopes; Optics; Outcome; Patients; Peripheral; Pigmentation physiologic function; Price; Procedures; Property; Pupil; Race; Resolution; Retina; Scanning; System; Telemedicine; Testing; Time; Validation; Visual impairment; Width; Work; base; comparative; cost; design; diabetes management; fundus imaging; handheld equipment; imager; imaging capabilities; instrument; low and middle-income countries; point of care; portability; prevent; prototype; recruit; retinal imaging; rural underserved; screening; success

R01 title: Nonmydriatic ultra-widefield fundus photography employing trans-pars-planar illumination Summary: This project is to develop a portable pan-retinal imaging device, and validate it for diabetic retinopathy (DR) screening and classification. As a leading cause of blindness, DR is a frequent complication of diabetes mellitus. Prompt screening and early diagnosis is essential to prevent visual impairment and blindness. Emerging widefield fundus photography has demonstrated its superior capability in DR screening, diagnosis and treatment evaluation. However, the high cost and operational complexity of existing widefield fundus imagers limit its potential for telemedicine DR examination, particularly in rural and underserved areas where both expensive instruments and skilled operators are not available. We have recently demonstrated the feasibility of trans-pars- planar illumination, i.e., delivering illuminating light through the pars plana outside of the pupil. By freeing the whole pupil for imaging purpose only, the trans-pars-planar illumination provides a unique opportunity to develop a low-cost, portable, non-mydriatic fundus camera with ultra-widefield coverage. Using all off-the-shelf parts, we have demonstrated a portable, contact-mode fundus camera to cover 200o field of view in a single snapshot image. We propose here to pursue custom-designed optics to develop a portable, eyeball contact-free 230o ultra- widefield fundus camera (u-WFC) to cover the whole retina in a single snapshot image. The first aim of this project is to refine a benchtop prototype WFC to quantitatively characterize optical property of the pars plana. Anticipated outcomes of the aim 1 study are 1) to establish power levels and exposure time required for different pigmentation levels and ages; 2) to establish adjustable distance/angle range of the illuminator; 3) to establish R/G/B ratios required for true color fundus imaging. These numbers will provide all necessary information to detail the system design and specification of the proposed portable u-WFC in Aim 2. The second aim is technical development of a portable u-WFC. The proposed u-WFC can work as either a low-cost handheld device with integrated trans-pars-planar illuminator, or a compact benchtop instrument. Preliminary test of the prototype u- WFC will be conducted using a model eye. FOV, central and peripheral spatial resolutions will be quantified by following the standard procedures defined in ISO 10940:2009. The third aim is clinical validation of the portable u-WFC. DR patients and healthy subjects will be recruited for clinical validation at UIC Retina Clinic. For functional comparison, fundus images will be acquired using the prototype u-WFC, ultra-widefield scanning laser ophthalmoscope (SLO) and OCT angiography (OCTA) at UIC Clinical Research Center of Ophthalmology. Key success criterion of this study is to verify that the portable 230o u-WFC can provide reliable DR detection sensitivity and repeatability, compared to 200o Optos 200Tx (Optos, Marlborough, MA).

R01标题：使用跨部分平面照明的非散瞳超宽视野眼底照相术 摘要：本项目旨在开发一种便携式全视网膜成像设备，并验证其对糖尿病视网膜病变的诊断价值 (Dr)筛选和分类。糖尿病视网膜病变是糖尿病的常见并发症，是导致失明的主要原因。 糖尿病。及时筛查和早期诊断是预防视力损伤和失明的关键。新兴 宽视场眼底照相术在糖尿病视网膜病变的筛查、诊断和治疗中显示出优越的能力。 评估。然而，现有宽视场眼底成像仪的高成本和操作复杂性限制了其 远程医疗DR检查的潜力，特别是在农村和服务不足的地区，那里的费用都很高 没有仪器和熟练的操作员。我们最近已经证明了TRAS-PAR的可行性- 平面照明，即通过瞳孔外的平坦部投射照明光。通过释放 全瞳孔仅用于成像目的，跨部分平面照明提供了一个独特的发展机会 一款低成本、便携、无散瞳、超宽视野覆盖的眼底相机。使用所有现成的部件，我们 我演示了一款便携式接触式眼底相机，可在一张快照中覆盖200O视场 图像。我们建议在这里追求定制设计的光学器件，以开发便携式、无眼球接触的230度超 宽视场眼底相机(u-WFC)在一张快照图像中覆盖整个视网膜。这样做的第一个目的是 项目是改进一个台式WFC原型，以定量表征平面部的光学性质。 Aim 1研究的预期结果是：1)确定不同的功率水平和暴露时间 色素沉着程度和年龄；2)建立照明器的可调距离/角度范围；3)建立 真彩色眼底成像所需的R/G/B比率。这些数字将提供所有必要的信息 详细介绍了目标2中提出的便携式u-WFC的系统设计和规范。第二个目标是技术 便携式u-wfc的研制。建议的u-wfc既可以作为低成本的手持设备使用，也可以使用 集成的横向平面照明器，或紧凑型台式仪器。样机U型的初步试验 WFC将使用模型眼进行。视场、中心和外围空间分辨率将通过以下方式量化 遵循国际标准化组织10940：2009中规定的标准程序。第三个目标是便携式的临床验证。 U-WFC。DR患者和健康受试者将被招募到UIC视网膜诊所进行临床验证。为 功能比较，将使用u-wfc原型超宽场扫描激光器获取眼底图像 UIC眼科临床研究中心的眼底镜(SLO)和OCT血管造影(OCTA)。钥匙 这项研究的成功标准是验证便携式2300 u-WFC可以提供可靠的DR检测 灵敏度和重复性，与200O Optos 200Tx(位于马萨诸塞州马尔伯勒的Optos)相比。