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Blood flow-based guidance and diagnostics using OCT

使用 OCT 基于血流的指导和诊断

基本信息

批准号：
10424917
负责人：
Nestor Uribe-Patarroyo
金额：
$ 12.83万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-01 至 2022-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10424917
关键词：
Address Affect Animal Experiments Animals Blindness Blood Blood Vessels Blood flow Bolus Infusion Catheters Cerebrovascular Disorders Cessation of life Clinical Clinical Trials Complex Coronary Coronary Arteriosclerosis Coronary artery Development Diabetic Retinopathy Diagnosis Diagnostic Disease Dyes Early Diagnosis Economic Burden Ethics Eye diseases Family suidae Fat emulsion Flowmetry Functional Imaging Glaucoma Healthcare Heart Diseases Human Image In Vitro Injections Intervention Macular degeneration Measurement Measures Mentors Morbidity - disease rate Optical Coherence Tomography Outcome Panthera leo Phase Pilot Projects Population Procedures Public Health Research Resolution Retinal Diseases Risk Signal Transduction Speed Structure System Techniques Testing Training Translating Validation Vision Disorders Visual impairment base burden of illness career development clinical application clinical practice cost design disease diagnosis experimental study human subject improved meetings mortality novel percutaneous coronary intervention pre-clinical premature response standard of care synergism technology development

项目摘要

7. Project Summary/Abstract Diseases diagnosed with assessment of blood flow account for 29% of deaths in the US and are leading causes of premature morbidity, including visual disorders which carry an economic burden of $35 bil- lion per year. The heart disease with the most impact on public health is coronary artery disease (CAD); more than one million percutaneous coronary interventions (PCI) are performed in the US ev- ery year. Among visual disorders diabetic retinopathy, macular degeneration and glaucoma are lead- ing causes of blindness in the US and affect 9% of the population over 40. All of these diseases are di- agnosed based on the qualitative assessment of blood flow using invasive dye contrast techniques. Extensive clinical trials have shown that guiding PCI based on quantitative blood flow assessment greatly improves the clinical outcome, but blood flow assessment requires catheters which are not in- tegrated with imaging catheters, increasing the intervention duration and therefore risk and cost. In- travascular optical coherence tomography (IV-OCT) has enabled high-resolution structural imaging of coronary arteries and can evaluate the response to PCI. Enabling blood flow quantification, flowmetry, with IV-OCT would provide functional information, critical to guide treatment and improve clinical outcomes. Similarly, OCT has been established as the standard of care in retinal diseases, providing critical structural imaging for diagnosis. It is known that early diagnosis of DR-MD-G requires func- tional information in the form of flowmetry, detecting changes in blood flow rate before the disease af- fects the vascular network structure and reducing associated vision loss. This project develops an OCT flowmetry technological platform, OCT-Flow, which relies on the analy- sis of the stochastic fluctuations of the OCT signal and its relation to the scatterers' velocity field. OCT- Flow will provide accurate flowmetry in complex-amplitude- and intensity-based modes. Upon com- pletion, OCT-Flow will be fully validated and will enable CAD treatment guidance and early eye-dis- ease diagnosis. The long-term impact of OCT-Flow will further include a wide range of clinical and preclinical applications, meeting the large demand for accurate flowmetry for treatment guidance and diagnosis in healthcare.

7.项目总结/摘要在美国，通过血流评估诊断的疾病占死亡人数的29%，过早发病的原因，包括视觉障碍，带来350亿美元的经济负担，狮子每年对公众健康影响最大的心脏病是冠心病 (CAD)在美国，每年有超过100万例经皮冠状动脉介入治疗（PCI），每年。在视力障碍中，糖尿病视网膜病变、黄斑变性和青光眼是主要的- 致盲的原因在美国和影响9%的人口超过40。所有这些疾病都是... 基于使用侵入性染料对比技术对血流的定性评估而不确定。大量的临床试验表明，基于定量血流评估的指导PCI 大大改善了临床结果，但血流评估需要导管，与成像导管集成，增加了介入时间，因此增加了风险和成本。在- 经血管光学相干断层扫描（IV-OCT）已经实现了高分辨率的结构成像，冠状动脉，并可以评估PCI的反应。使血流定量，血流测定， IV-OCT将提供功能信息，这对于指导治疗和改善临床结果。类似地，OCT已被确立为视网膜疾病的护理标准，关键的结构成像诊断。众所周知，DR-MD-G的早期诊断需要功能- 以流量计的形式提供常规信息，检测疾病发生前血液流速的变化，影响血管网络结构并减少相关的视力丧失。本课题开发了OCT流量测量技术平台OCT-Flow。 OCT信号的随机起伏及其与散射体速度场的关系。OCT- Flow将在基于复振幅和强度的模式下提供准确的流量测定。在com- 此外，OCT-Flow将得到充分验证，并将实现CAD治疗指导和早期眼部疾病- 方便诊断。OCT-Flow的长期影响将进一步包括广泛的临床和临床前应用，满足治疗指导对精确流量测量的大量需求，医疗诊断。