Modulating stimulus intensity to improve clinical outcomes in aphasia treatment
调节刺激强度以改善失语症治疗的临床结果
基本信息
- 批准号:10424517
- 负责人:
- 金额:$ 61.21万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-07-09 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAffectiveAftercareAphasiaBehaviorClientClinicalClinical TreatmentCognitive ScienceCommunication impairmentCommunitiesComplexComputer ModelsComputersDoseEducational process of instructingEffectivenessElementsEnsureEnvironmentFrequenciesGoalsHomeIn SituIndividualInterventionInvestigationLarynxLearningLinguisticsLiteratureLongevityMaintenanceMeasuresModelingNamesNeurologicNeuronal PlasticityNeurosciencesOutcomeOutcome MeasureParticipantPatternPersonalityPersonsPrivacyProductionReportingResearchResponse GeneralizationScheduleSecondary toSpeech IntelligibilityStimulusStimulus GeneralizationTabletsTimeTrainingTreatment Effectivenessclinical applicationclinical practicecomputerizedcostcost effectivecost effective treatmentdesignimprovedinnovationlong-term rehabilitationprimary outcomesecondary outcomesensorsoundtreatment armtreatment programvirtualvisual speechwireless
项目摘要
Abstract
Determining the optimal intensity of treatment is essential to the design and implementation of any
treatment program for aphasia. Yet, treatment intensity is a complex construct and information on the variables
modulating it remain ambiguous and limited. Studies reported in the neuroscience and clinical literature
support the need for intensive treatment to induce long-term neuroplastic changes while the cognitive
psychology literature suggests that learning is best maintained with distributed schedules. A few studies have
looked at dose parameters for single word naming tasks, but there is limited evidence regarding dose
parameters for treatments that focus on training the production of larger units, such as sentences or even
connected discourse. One approach that is frequently used clinically and has evidence for its efficacy is script
training. Little is currently known regarding the optimum dose of script training (i.e., the number of repetitions
over time of each sentence within the script) that is required to promote the best outcomes.
In this proposal we conduct a two-factor RCT on the effects of modulating stimulus variables, specifically
stimulus practice distribution and stimulus repetition. We use a baseline script treatment that has experimental
support regarding its efficacy, and that allows the manipulation of these variables. To ensure independence
and fidelity, treatment is provided in a controlled computer environment (desktop and tablet). To avoid clinician-
related variables such as expertise and personality factors that may influence treatment, sentences are
modeled during treatment by an anthropomorphic agent with high visual speech intelligibility and affective
expressions.
With regard to “best outcomes”, generalization is the ultimate goal of any treatment approach. Therefore,
the primary outcome is a generalization measure of conversation. Secondary measures address short-term
acquisition, longer-term maintenance, and response generalization for assessing gain over baseline,
differential effects, and interactions. A mobile-connected wireless wearable laryngeal sensor allows tracking of
talk time at home and in the community as a measure of treatment effectiveness and transfer. For privacy, it
does not record audio.
Results and computational models of learning (generalization, short-term acquisition, and longer-term
maintenance) will contribute new evidence to fill critical gaps in current scientific understanding regarding the
effectiveness and clinical application of aphasia treatment approaches. More generally, findings will help to
inform clinical practice and treatment of neurologic communication disorders; the virtual clinician guided
intervention that the proposal develops has the potential to reduce costly clinician-client time otherwise
required for long-term rehabilitation.
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摘要
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Leora R Cherney其他文献
Leora R Cherney的其他文献
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{{ truncateString('Leora R Cherney', 18)}}的其他基金
Ethical considerations implementing wearable sensors to record communication interactions by people with aphasia in the home and community
使用可穿戴传感器记录失语症患者在家庭和社区中的交流互动的伦理考虑
- 批准号:
10594286 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
Defining Trajectories of Linguistic, Cognitive-Communicative and Quality of Life Outcomes in Aphasia
定义失语症的语言、认知交际和生活质量结果的轨迹
- 批准号:
10376798 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
Modulating stimulus intensity to improve clinical outcomes in aphasia treatment
调节刺激强度以改善失语症治疗的临床结果
- 批准号:
10194454 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
Defining Trajectories of Linguistic, Cognitive-Communicative and Quality of Life Outcomes in Aphasia
定义失语症的语言、认知交际和生活质量结果的轨迹
- 批准号:
10614491 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
Modulating stimulus intensity to improve clinical outcomes in aphasia treatment
调节刺激强度以改善失语症治疗的临床结果
- 批准号:
10642964 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
Modulating stimulus intensity to improve clinical outcomes in aphasia treatment
调节刺激强度以改善失语症治疗的临床结果
- 批准号:
9974499 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
Defining Trajectories of Linguistic, Cognitive-Communicative and Quality of Life Outcomes in Aphasia
定义失语症的语言、认知交际和生活质量结果的轨迹
- 批准号:
9912743 - 财政年份:2019
- 资助金额:
$ 61.21万 - 项目类别:
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