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Mechanisms of Developmental Plasticity in the Mammalian Olfactory System

哺乳动物嗅觉系统发育可塑性机制

基本信息

批准号：
10424507
负责人：
Congrong Ron Yu
金额：
$ 47.27万
依托单位：
STOWERS INSTITUTE FOR MEDICAL RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10424507
关键词：
Adult Affect Aging Alzheimer&apos s Disease Animals Axon Behavior Birth Brain Candidate Disease Gene Continuous Infusion Data Development Developmental Process Embryo Failure Gene Expression Profile Genes Genetic Goals Growth Impairment Knowledge Label Lead Life Maps Molecular Motivation Mus Natural regeneration Nervous System Physiology Nervous system structure Neurodegenerative Disorders Neurons Olfactory Epithelium Olfactory Pathways Parkinson Disease Pathologic Pattern Perinatal Play Positioning Attribute Process Quality of life Regenerative Medicine Regenerative capacity Regulation Role Sensory Structure System Systems Development Testing WNT Signaling Pathway adult neurogenesis axonal pathfinding brain cell critical period deprivation developmental plasticity experimental study functional restoration genetic manipulation genetic testing innovation insight loss of function mature animal nerve stem cell neurodevelopment neuron development neuron regeneration novel novel strategies olfactory bulb olfactory sensory neurons postnatal postnatal development postnatal period preventive intervention programs public health relevance receptor regenerative repair relating to nervous system repaired scaffold sensory system single-cell RNA sequencing transcriptome

项目摘要

Project Summary/Abstract. In the mammalian brain, the olfactory bulb is the only region that receives not only continuous infusion of neuronal progenitor cells from the brain, but also renewed input from the olfactory epithelium. The olfactory sensory neurons (OSNs) continuously regenerate throughout the life of the animal. The newly-generated OSNs project precisely to stereotypical positions in the olfactory bulb to maintain a sensory map. It has been thought that the olfactory system does not exhibit a critical period during development because of its unique, continuous regenerative capacity. Our recent results show that axonal targeting of the OSNs is sensitive to deprivation of neural activity and other perturbations during the first postnatal week in olfactory development, suggesting a critical period in OSN axon targeting. Our data further suggest that two separate developmental programs underlie the precise targeting of the OSNs before and after the critical period. The switch is accompanied by a prominent change in the patterns of gene expression. The objective of this application is to determine the molecular control of the critical period in olfactory system development. By combining genetic manipulation and transcriptome analyses, we have developed approaches that allow us to directly compare the developmental programs during early postnatal period and in adulthood. We have identified candidate genes and we will test their role in determining the axon dynamics during the critical period and their role in determining the timing of the critical period. These studies will provide mechanistic insights into axon pathfinding during OSN development and during adult neurogenesis.

项目总结/抽象。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Identification and Localization of Cell Types in the Mouse Olfactory Bulb Using Slide-SeqV2.

使用 Slide-SeqV2 识别和定位小鼠嗅球中的细胞类型。

DOI：
10.1007/978-1-0716-3425-7_13
发表时间：
2023
期刊：
Methods in molecular biology (Clifton, N.J.)
影响因子：
0
作者：
Fang,Ai;Petentler,Kaitlyn;Price,Andrew;Malloy,Seth;Peterson,Michael;Maddera,Lucinda;Russell,Jonathon;Treese,McKenzie;Li,Hua;Wang,Yongfu;McKinney,Sean;Perera,Anoja;Yu,CRon
通讯作者：
Yu,CRon

Encoding innately recognized odors via a generalized population code.