Genetic Mapping of Functional Vomeronasal Circuit
功能性犁鼻环路的基因图谱
基本信息
- 批准号:7850288
- 负责人:
- 金额:$ 23万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-07-17 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:Accessory Olfactory BulbsAddressAfferent NeuronsAggressive behaviorAlzheimer&aposs DiseaseAnimalsAttention deficit hyperactivity disorderAutistic DisorderBehaviorBehavioralBehavioral AssayBrainCalciumCampingCellsChemicalsChromosome MappingCuesDefectDetectionDiagnosticDiscriminationFemaleGenderGeneticGenetic SuppressionGoalsHealthImageImaging TechniquesIndividualInstinctKnowledgeLabelLacZ GenesLightLinkMapsMental disordersMethodsMolecular BiologyMonitorMusNeurologicNeuronsOutputParkinson DiseasePartner in relationshipPathway interactionsPatternPerceptionPheromonePheromone ReceptorsPopulationProteinsReceptor GeneResearch PersonnelReverse Transcriptase Polymerase Chain ReactionRitual compulsionSamplingSchizophreniaSensorySensory ProcessStereotypingSystemTestingTetanus ToxinTetracyclinesTherapeuticTransgenic AnimalsUrineVertebratesVomeronasal Systemsbasecalcium indicatordepressioninformation processinginsightinward rectifier potassium channelmaleneural circuitprogramspromoterreceptorrelating to nervous systemreproductiveresearch studyresponseselective expressionsensory mechanismsensory systemsocialvomeronasal organ
项目摘要
The major goal of this proposal is to understand the mechanisms and the general principles involved in
sensory informationprocessing. The proper function of the sensory systems is crucial to our health and well
being. Numerous neurological and psychiatric disorders, such as schizophrenia, autism, attention deficit
hyperactivity disorder (ADHD) and depression, all manifest defects in sensory responses. Sensory deficit is
also the earliest sign of Parkinson's and Alzheimer's diseases. The study of the sensory systems will enable
us to understand how the brain functions and help us to use this knowledge for diagnostic and therapeutic
applications. To achieve this goal, one must study the neural circuitry that detects and integrates sensory input
and elicits distinct behavioral output. In vertebrates, innate behaviors such as mating rituals and territorial
aggression are largely elicited by the detection of pheromone cues through the vomeronasal organ. These
behaviors are robust and stereotyped and their expression critically depends on the correct identification of
pheromones. The neural circuits involved in pheromone detection are largely genetically determined. There is
an intrinsic link between sensory input and behavior responses in the vomeronasal system, making it an
attractive and tractable circuitry to understand sensory processing.
In this study, we test the hypothesis that sensory information is encoded in the pattern of activation by
different pheromones in the sensory cells. This information is further represented in the brain by the
topographic projection from these neurons to allow an animal to discriminate gender, strain and the social and
reproductive status of other individuals. We will first develop transgenic animals expressing calcium
indicators in the sensory neurons to identify cells that respond to specific pheromones. Combining fluorescent
imaging, mouse genetics and molecular biology, we will then identify the pheromone receptor gene these
cells express. Third, we will trace the information flow by mapping the vomeronasal pathway with genetic
labeling experiments. Finally, we will genetically inactivate subpopulations of neurons in the vomeronasal
pathway to elucidate their functional contribution to pheromone perception. This functional mapping of the
vomeronasal circuit will provide insight into how the sensory system detects, parses and integrates
information to elicit specific behaviors.
本提案的主要目标是了解所涉及的机制和一般原则
项目成果
期刊论文数量(0)
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{{ truncateString('Congrong Ron Yu', 18)}}的其他基金
Circuit Mechanism of Pheromone Processing and Innate Behavior
信息素加工和先天行为的回路机制
- 批准号:
10601689 - 财政年份:2023
- 资助金额:
$ 23万 - 项目类别:
Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
哺乳动物嗅觉系统发育可塑性机制
- 批准号:
10174905 - 财政年份:2018
- 资助金额:
$ 23万 - 项目类别:
Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
哺乳动物嗅觉系统发育可塑性机制
- 批准号:
10119618 - 财政年份:2018
- 资助金额:
$ 23万 - 项目类别:
Mechanisms of Developmental Plasticity in the Mammalian Olfactory System
哺乳动物嗅觉系统发育可塑性机制
- 批准号:
10424507 - 财政年份:2018
- 资助金额:
$ 23万 - 项目类别:
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