Immersive Training in Glycosciences
糖科学沉浸式培训
基本信息
- 批准号:10424530
- 负责人:
- 金额:$ 95.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:Biomedical EngineeringBiomedical ResearchCardiologyClinicClinicalDevelopmentDiseaseDoctor of MedicineDoctor of PhilosophyFacultyFellowship ProgramGrantImmersionIndividualKnowledgeLearningMentorsMolecularMonitorNational Heart, Lung, and Blood InstitutePhysiciansPolysaccharidesProgram DevelopmentPublicationsPulmonologyResearchReview LiteratureScientistSeriesSystemTrainingTranslational ResearchUniversitiesWritingcareercareer developmentexperiencehuman diseaselaboratory curriculumlecturesnext generationprogramsrecruitskillssuccess
项目摘要
The program directors and faculty from three of the six prior NHLBI Program of Excellence in
Glycoscience (PEG) centers have joined forces with top quality physician scientists at the Cleveland Clinic
and at Johns Hopkins to create a unique career development program that will train the next generation of
leaders in biomedical research involving glycans and human disease. Scholars will be selected by either an
advertised national search or by selecting individuals who were already nationally recruited by highly
competitive searches to local fellowship programs in cardiology, pulmonology or biomedical engineering.
Five scholars will be selected during the first cycle of the Program. Five additional Scholars will be selected
in the second cycle of the Program. Each Scholar will have at-least two co-mentors, one a leading expert in
glycoscience and the other(s) leading experts in clinical/translational research on a disease of high priority
to NHLBI. Selection of Scholars will favor individuals with the M.D. or M.D.-Ph.D. degree. The objectives of
our career development program are to provide immersion in state-of-the art glycosciences relevant to
human disease for both Scholars and their clinical co-mentors. The career development program will
consist of a multi-faceted immersion in disease-related glycosciences. Research experiences will be
supplemented by a) advanced topic lectures; b) translational glycoscience examples & applications; c)
thematic literature reviews; d) glycoscience seminar series; and e) research in progress. This training will be
simulcast at the Cleveland Clinic or Johns Hopkins University (JHU) as needed. f) Scholars will also take a
hands-on laboratory course, where they will learn major skills required to do research in glycosciences.
Biomedical glycoscience career development will be further supported by professional development
opportunities, focused on grant writing, presentation skills, and networking. Attendance at all Program
activities by Scholars will be mandatory. Participation and progress of Scholars will be collectively overseen
by the internal oversight committee, comprised of all of the Co-P.I.s. A formal electronic system for
evaluating both the Scholars and mentors will be established. The overall Program will be evaluated
annually by an outside review panel, comprised of leading glycoscientists. We will also monitor publications,
presentations and career trajectories of present and former Scholars to evaluate the overall success of the
Program. Our Program will create a cadre of physician scientists who not only will become leaders in
disease-related research, but also will be well versed in the glycosciences required to understand the
molecular basis of disease. True success of the Program will occur as these Scholars are now able to pass
on their knowledge of the importance of glycans to their own Fellows when they become independent
physician scientists.
来自六个先前的NHLBI卓越计划中的三个的计划主任和教师,
糖科学(PEG)中心与克利夫兰诊所的顶级医生科学家联手
在约翰霍普金斯大学,我们创建了一个独特的职业发展计划,
生物医学研究领域的领导者,涉及聚糖和人类疾病。学者将由一个
广告全国搜索或选择个人谁已经在全国范围内招募的高度
竞争性搜索到心脏病学,肺病学或生物医学工程的当地奖学金计划。
在方案第一周期将选出五名学者。将选出另外五名学者
在该计划的第二个周期。每个学者将有至少两个共同导师,一个是领先的专家,
糖科学和其他高优先级疾病临床/转化研究领域的领先专家
关于NHLBI学者的选择将有利于个人与医学博士。或者医学博士博士℃下的目标
我们的职业发展计划是提供沉浸在最先进的糖科学相关,
人类疾病的学者和他们的临床共同导师。职业发展计划将
包括多方面的沉浸在疾病相关的糖科学。研究经验将是
辅以a)高级专题讲座; B)转化糖科学实例和应用; c)
专题文献综述; d)糖科学系列研讨会;以及e)进行中的研究。将培训以文件形式进行
根据需要在克利夫兰诊所或约翰霍普金斯大学(JHU)进行联播。(f)学者也将参加一个
实践实验室课程,在那里他们将学习进行糖科学研究所需的主要技能。
生物医学糖科学职业发展将进一步得到专业发展的支持
机会,侧重于赠款写作,演讲技巧和网络。出席所有方案
学者的活动将是强制性的。学者的参与和进展将受到集体监督
内部监督委员会由所有首席执行官组成一个正式的电子系统,
评估学者和导师将建立。将对整个方案进行评估
每年由一个由领先的糖科学家组成的外部审查小组进行审查。我们还将监测出版物,
介绍和职业轨迹的现任和前任学者,以评估的整体成功
程序.我们的计划将创造一个医生科学家的干部,他们不仅将成为领导者,
疾病相关的研究,但也将精通所需的糖科学,以了解
疾病的分子基础该计划的真正成功将发生,因为这些学者现在能够通过
当他们独立时,他们对聚糖对自己同伴的重要性的了解
医学科学家
项目成果
期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Critical observations that shaped our understanding of the function(s) of intracellular glycosylation (O-GlcNAc).
批判性观察塑造了我们对细胞内糖基化功能(O-GLCNAC)功能的理解。
- DOI:10.1002/1873-3468.13286
- 发表时间:2018-12
- 期刊:
- 影响因子:3.5
- 作者:Zachara NE
- 通讯作者:Zachara NE
Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3.
转化生长因子-β 受体介导的 p38 丝裂原激活蛋白激酶依赖性信号传导在缺乏透明质酸合成酶 1 和 3 的小鼠皮肤伤口愈合过程中增强肌成纤维细胞分化。
- DOI:10.1016/j.ajpath.2022.08.003
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:Wang,Yan;Mack,JudithA;Hascall,VincentC;Maytin,EdwardV
- 通讯作者:Maytin,EdwardV
Monocyte adhesive hyaluronan matrix induced by hyperglycemia in diabetic lung injuries.
- DOI:10.1016/j.jbc.2023.104995
- 发表时间:2023-08
- 期刊:
- 影响因子:4.8
- 作者:Wang, Andrew Jun;Ren, Juan;Wang, Aimin;Hascall, Vincent C.
- 通讯作者:Hascall, Vincent C.
Integration of O-GlcNAc into Stress Response Pathways.
- DOI:10.3390/cells11213509
- 发表时间:2022-11-05
- 期刊:
- 影响因子:6
- 作者:
- 通讯作者:
Detection and Analysis of Proteins Modified by O-Linked N-Acetylglucosamine.
- DOI:10.1002/cpz1.129
- 发表时间:2021-05
- 期刊:
- 影响因子:0
- 作者:Fahie K;Narayanan B;Zahra F;Reeves R;Fernandes SM;Hart GW;Zachara NE
- 通讯作者:Zachara NE
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VINCENT CHARLES HASCALL其他文献
VINCENT CHARLES HASCALL的其他文献
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{{ truncateString('VINCENT CHARLES HASCALL', 18)}}的其他基金
TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
TSG-6:炎症气道中病毒诱导的透明质酸合成的新型调节剂
- 批准号:
9069956 - 财政年份:2013
- 资助金额:
$ 95.49万 - 项目类别:
TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
TSG-6:炎症气道中病毒诱导的透明质酸合成的新型调节剂
- 批准号:
8849492 - 财政年份:2013
- 资助金额:
$ 95.49万 - 项目类别:
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