Immersive Training in Glycosciences
Immersive Training in Glycosciences
批准号:
10424530
负责人:
VINCENT CHARLES HASCALL
金额:
$95.49万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-07-01 至 2024-06-30
关键词:
Biomedical EngineeringBiomedical ResearchCardiologyClinicClinicalDevelopmentDiseaseDoctor of MedicineDoctor of PhilosophyFacultyFellowship ProgramGrantImmersionIndividualKnowledgeLearningMentorsMolecularMonitorNational Heart, Lung, and Blood InstitutePhysiciansPolysaccharidesProgram DevelopmentPublicationsPulmonologyResearchReview LiteratureScientistSeriesSystemTrainingTranslational ResearchUniversitiesWritingcareercareer developmentexperiencehuman diseaselaboratory curriculumlecturesnext generationprogramsrecruitskillssuccess
中文摘要
前六个NHLBI卓越计划中的三个计划的主任和教职员工
血糖科学(PEG)中心与克利夫兰诊所的顶尖内科科学家联手
并在约翰霍普金斯大学创建了一个独特的职业发展计划,将培训下一代
在涉及多糖和人类疾病的生物医学研究方面处于领先地位。奖学金获得者将由以下其中之一选出
广告全国搜索或通过选择已经在全国范围内招聘的个人
对心脏病学、肺病学或生物医学工程方面的本地奖学金项目进行竞争性搜索。
在该计划的第一个周期中,将选出五名学者。将再选出五名学者
在该方案的第二个周期中。每位奖学金获得者将至少有两位共同导师,其中一位是
血糖科学和其他(S)在一种高度优先的疾病的临床/翻译研究方面的领先专家
致NHLBI。奖学金获得者将优先考虑拥有医学博士或医学博士学位的个人。的目标
我们的职业发展计划是提供与以下相关的最先进的糖科学
对学者和他们的临床导师来说都是人类疾病。职业发展计划将
包括多方面沉浸在与疾病相关的糖科学中。研究经验将是
辅以a)高级专题讲座;b)翻译糖科学实例和应用;c)
专题文献综述;d)糖科学系列研讨会;e)正在进行的研究。这次培训将是
根据需要在克利夫兰诊所或约翰霍普金斯大学(JHU)同步转播。F)学者还将参加
动手实验室课程,在那里他们将学习做糖科学研究所需的主要技能。
专业发展将进一步支持生物医学糖科学职业发展
机会,重点放在赠款撰写、演示技能和网络方面。出席所有活动
奖学金获得者的活动将是强制性的。学者的参与和进步将受到集体监督
由所有合作伙伴组成的内部监督委员会。一种正式的电子系统
将建立对学者和导师的评估。将对整个计划进行评估
每年由一个由领先的血糖科学家组成的外部审查小组进行。我们还将监测出版物,
现任和前任学者的陈述和职业轨迹,以评估该项目的总体成功
程序。我们的计划将培养一支内科科学家干部队伍,他们不仅将成为
与疾病相关的研究,还将精通所需的糖科学,以了解
疾病的分子基础。当这些学者现在能够通过时,计划将会真正成功
当他们独立时,他们知道葡聚糖对他们的同伴的重要性
内科科学家。
英文摘要
The program directors and faculty from three of the six prior NHLBI Program of Excellence in
Glycoscience (PEG) centers have joined forces with top quality physician scientists at the Cleveland Clinic
and at Johns Hopkins to create a unique career development program that will train the next generation of
leaders in biomedical research involving glycans and human disease. Scholars will be selected by either an
advertised national search or by selecting individuals who were already nationally recruited by highly
competitive searches to local fellowship programs in cardiology, pulmonology or biomedical engineering.
Five scholars will be selected during the first cycle of the Program. Five additional Scholars will be selected
in the second cycle of the Program. Each Scholar will have at-least two co-mentors, one a leading expert in
glycoscience and the other(s) leading experts in clinical/translational research on a disease of high priority
to NHLBI. Selection of Scholars will favor individuals with the M.D. or M.D.-Ph.D. degree. The objectives of
our career development program are to provide immersion in state-of-the art glycosciences relevant to
human disease for both Scholars and their clinical co-mentors. The career development program will
consist of a multi-faceted immersion in disease-related glycosciences. Research experiences will be
supplemented by a) advanced topic lectures; b) translational glycoscience examples & applications; c)
thematic literature reviews; d) glycoscience seminar series; and e) research in progress. This training will be
simulcast at the Cleveland Clinic or Johns Hopkins University (JHU) as needed. f) Scholars will also take a
hands-on laboratory course, where they will learn major skills required to do research in glycosciences.
Biomedical glycoscience career development will be further supported by professional development
opportunities, focused on grant writing, presentation skills, and networking. Attendance at all Program
activities by Scholars will be mandatory. Participation and progress of Scholars will be collectively overseen
by the internal oversight committee, comprised of all of the Co-P.I.s. A formal electronic system for
evaluating both the Scholars and mentors will be established. The overall Program will be evaluated
annually by an outside review panel, comprised of leading glycoscientists. We will also monitor publications,
presentations and career trajectories of present and former Scholars to evaluate the overall success of the
Program. Our Program will create a cadre of physician scientists who not only will become leaders in
disease-related research, but also will be well versed in the glycosciences required to understand the
molecular basis of disease. True success of the Program will occur as these Scholars are now able to pass
on their knowledge of the importance of glycans to their own Fellows when they become independent
physician scientists.
期刊论文(11)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Critical observations that shaped our understanding of the function(s) of intracellular glycosylation (O-GlcNAc).
批判性观察塑造了我们对细胞内糖基化功能(O-GLCNAC)功能的理解。
DOI:
10.1002/1873-3468.13286
发表时间:
2018-12
期刊:
FEBS letters
影响因子:
3.5
作者:
[Zachara NE]
通讯作者:
Zachara NE
Transforming Growth Factor-β Receptor-Mediated, p38 Mitogen-Activated Protein Kinase-Dependent Signaling Drives Enhanced Myofibroblast Differentiation during Skin Wound Healing in Mice Lacking Hyaluronan Synthases 1 and 3.
转化生长因子-β 受体介导的 p38 丝裂原激活蛋白激酶依赖性信号传导在缺乏透明质酸合成酶 1 和 3 的小鼠皮肤伤口愈合过程中增强肌成纤维细胞分化。
DOI:
10.1016/j.ajpath.2022.08.003
发表时间:
2022
期刊:
The American journal of pathology
影响因子:
--
作者:
[Wang,Yan, Mack,JudithA, Hascall,VincentC, Maytin,EdwardV]
通讯作者:
Maytin,EdwardV
DOI:
10.1016/j.jbc.2023.104995
发表时间:
2023-08
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Wang, Andrew Jun, Ren, Juan, Wang, Aimin, Hascall, Vincent C.]
通讯作者:
Hascall, Vincent C.
DOI:
10.3390/cells11213509
发表时间:
2022-11-05
期刊:
Cells
影响因子:
6
作者:
[]
通讯作者:
DOI:
10.1002/cpz1.129
发表时间:
2021-05
期刊:
Current protocols
影响因子:
--
作者:
[Fahie K, Narayanan B, Zahra F, Reeves R, Fernandes SM, Hart GW, Zachara NE]
通讯作者:
Zachara NE
共 6 条
Immersive Training in Glycosciences
-
批准号:10197206
-
项目类别:
-
资助金额:$95.93万
-
财政年份:2018
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
-
批准号:9069956
-
项目类别:
-
资助金额:$31.7万
-
财政年份:2013
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
TSG-6: Novel Regulator of Viral-Induced Hyaluronan Synthesis in Inflamed Airways
-
批准号:8849492
-
项目类别:
-
资助金额:$31.22万
-
财政年份:2013
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Hyaluronan Matrices in Vascular Pathologies
-
批准号:8291915
-
项目类别:
-
资助金额:$239.82万
-
财政年份:2011
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Hyaluronan Matrices in Vascular Pathologies
-
批准号:8072346
-
项目类别:
-
资助金额:$245.82万
-
财政年份:2011
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Hyaluronan Matrices in Vascular Pathologies
-
批准号:8856310
-
项目类别:
-
资助金额:$219.63万
-
财政年份:2011
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Hyaluronan Matrices in Vascular Pathologies
-
批准号:8494077
-
项目类别:
-
资助金额:$217.54万
-
财政年份:2011
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Hyaluronan Matrices in Vascular Pathologies
-
批准号:8669079
-
项目类别:
-
资助金额:$221.18万
-
财政年份:2011
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Imaging Core
-
批准号:7590430
-
项目类别:
-
资助金额:$24.16万
-
财政年份:2008
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Robotics Core
-
批准号:7590432
-
项目类别:
-
资助金额:$23.62万
-
财政年份:2008
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Histology Core
-
批准号:7590431
-
项目类别:
-
资助金额:$10.09万
-
财政年份:2008
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Robotics Core
-
批准号:7478185
-
项目类别:
-
资助金额:$14.61万
-
财政年份:2007
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Project 1
-
批准号:7478186
-
项目类别:
-
资助金额:$4.79万
-
财政年份:2007
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Imaging Core
-
批准号:7478183
-
项目类别:
-
资助金额:$14.37万
-
财政年份:2007
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Administrative Core
-
批准号:7478182
-
项目类别:
-
资助金额:$10.27万
-
财政年份:2007
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Histology Core
-
批准号:7478184
-
项目类别:
-
资助金额:$9.05万
-
财政年份:2007
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
Project 2
-
批准号:7478187
-
项目类别:
-
资助金额:$4.77万
-
财政年份:2007
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
CCF Musculoskeletal Core Center
-
批准号:6751360
-
项目类别:
-
资助金额:$54.67万
-
财政年份:2004
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
CCF Musculoskeletal Core Center
-
批准号:7213458
-
项目类别:
-
资助金额:$57.87万
-
财政年份:2004
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
CCF Musculoskeletal Core Center
-
批准号:6890476
-
项目类别:
-
资助金额:$59.6万
-
财政年份:2004
-
负责人:VINCENT CHARLES HASCALL
-
依托单位:
海外基金