Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort

新生儿表观遗传学研究 (NEST) 队列的随访和维护

• 批准号: 10443683
• 负责人: Cathrine Hoyo
• 金额: $ 38.02万
• 依托单位: NORTH CAROLINA STATE UNIVERSITY RALEIGH
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-30 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10443683
• 关键词: Aberrant DNA Methylation; Address; Adult; Age; Algorithms; Architecture; Arsenic; Biological Specimen Banks; Birth; Blood; Blood Pressure; Cadmium; Cardiometabolic Disease; Cardiovascular Diseases; Cause of Death; Chemicals; Child; Childhood; Chronic Disease; Clinic; Clinical Data; Code; Cohort Studies; Collaborations; Communities; Consent; County; Cross-Sectional Studies; DNA Methylation; Data; Data Collection; Data Linkages; Data Set; Data Sources; Databases; Developed Countries; Developing Countries; Development; Diagnosis; Discipline; Disease; Drug Prescriptions; Elderly; Embryo; Enrollment; Ensure; Environment; Environmental Exposure; Epidemiologist; Epigenetic Process; Etiology; Exposure to; Follow-Up Studies; Functional disorder; Funding; Gastroenterology; Genes; Genetic; Geography; Goals; Growth; Health system; Heavy Metals; Height; High Prevalence; Hyperglycemia; Hyperinsulinism; Hyperlipidemia; Impairment; Internet; Investigation; Knowledge; Lead; Life; Life Cycle Stages; Link; Longterm Follow-up; Low Birth Weight Infant; Maintenance; Malignant Neoplasms; Medicaid; Medical Records; Meta-Analysis; Metabolic; Metabolic Diseases; Methylation; Newborn Infant; Non-Insulin-Dependent Diabetes Mellitus; Nutrient; Obesity; Obesity associated cancer; Online Systems; Onset of illness; Outcome; Paper; Participant; Pediatrics; Perinatology; Persons; Policies; Predisposition; Pregnant Women; Prevalence; Procedures; Process; Prospective cohort; Protocols documentation; Psychology; Puberty; Quality Control; Questionnaires; Reporting; Research; Resources; Retrospective Studies; Retrospective cohort study; Running; Soil; Specimen; Standardization; Testing; Time; Toxicology; Training; Weight; Woman; aged; blood lead; cardiometabolism; cardiovascular risk factor; cigarette smoking; cohort; data repository; data reuse; data sharing; design; early life exposure; environmental chemistry; epidemiologic data; epigenome; epigenomics; folic acid supplementation; follow-up; human subject protection; imprint; improved; in utero; lead exposure; maternal obesity; neurodevelopment; neurodevelopmental effect; novel; nutrition; offspring; pollutant; prenatal; prenatal exposure; preservation; programs; public health intervention; quality assurance; recruit; sample collection; searchable database; skills; stem; stressor; superfund site; usability

Project Summary Non-communicable diseases including cardiovascular diseases, metabolic diseases and cancer are the leading causes of death in developed countries. These diseases are predicted to also be the leading causes of death in developing countries by 2020. Stemming the increase in the prevalence of these diseases will require a more detailed understanding of their etiology using a life course approach. Existing data linking early chemical and non-chemical stressors to these adult-onset diseases derives either from well-powered cross- section or retrospective cohort studies, or under-powered prospective cohorts with short follow-up. Epigenetic alterations—a mechanism by which genes respond to the environment—have been hypothesized to link observed associations between early stressors and multiple common diseases. However, prior cross-sectional and retrospective studies have lacked early life covariate data and specimens that would help to examine the links between early life stressors and later life disease. To address these knowledge gaps, in 2005-2011, we developed the pre-birth Newborn Epigenetics STudy (NEST) cohort comprising more than 2000 women, and followed their offspring until age 3-5 years. The NEST cohort has become a resource used by our group to identify novel associations between chemical and non-chemical stressors, and early signs of these non- communicable diseases, including cardiometabolic dysfunction. This resource has also been used to replicate novel findings by other groups, to pool with other cohorts to enhance statistical power, and to test new hypotheses by others. Our overarching goal for this application is to maintain this resource. This will be accomplished through the retention of trained staff with the critical skills to, (i) maintain and enrich the cohort by collecting additional data and specimens, (ii) develop and implement quality control and quality assurance protocols on existing and to-be-collected data and specimens, and, (iii) establish a comprehensive web-based database to increase our capability for data re-use and pooling with other cohorts to enhance statistical power. Direct web access will also simplify the process of data sharing with other birth cohorts and prepare our data for linkage. We will follow the cohort until age 11-17 years. This age range coincides with peri-puberty and puberty—developmental windows of heightened susceptibility to the non-communicable diseases under investigation. We also will link NEST data with identifiable Health System- and State-run medical records. Completing the proposed study will result in an enriched specimen repository with quality control and quality assurance, and annotated epidemiologic and clinical data. These data and specimens will facilitate rapid hypothesis testing by our group as well as data sharing and linkage with other cohorts to enhance statistical power. Data contributing to our understanding of the developmental origins of adult-onset non-communicable diseases are critical for guiding public health intervention efforts.

项目总结

项目成果

A specialized metabolic pathway partitions citrate in hydroxyapatite to impact mineralization of bones and teeth.

• DOI: 10.1073/pnas.2212178119
• 发表时间: 2022-11-08
• 期刊: Proceedings of the National Academy of Sciences of the United States of America
• 影响因子: 11.1

A Cross-Sectional Cohort Study of the Effects of FGF23 Deficiency and Hyperphosphatemia on Dental Structures in Hyperphosphatemic Familial Tumoral Calcinosis.

• DOI: 10.1002/jbm4.10470
• 发表时间: 2021-05
• 期刊: JBMR plus
• 影响因子: 3.8
• 作者: Lee AE;Chu EY;Gardner PJ;Duverger O;Saikali A;Wang SK;Gafni RI;Hartley IR;Ten Hagen KG;Somerman MJ;Collins MT
• 通讯作者: Collins MT