Characterizing the Human Imprint Regulatory Regions Associated with Childhood Obesity

表征与儿童肥胖相关的人类印记调节区域

基本信息

  • 批准号:
    10662238
  • 负责人:
  • 金额:
    $ 56.78万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-06 至 2024-06-30
  • 项目状态:
    已结题

项目摘要

PROJECT SUMMARY/ABSTRACT The rapid increase in the prevalence of obesity in the last 30 years has led to the hypothesis that epigenetic mechanisms mediate associations between environmental cues and obesity outcomes. Nevertheless, epigenetic regions that alter obesity risk are still largely unknown. We presently lack a screening tool for comprehensive measurement of epigenetic modifications. Such a screen in any disease or exposure of interest would be of great utility for a broad range of human health studies. The interpretation of human epigenetic data generated using genome-scale approaches is hampered by three main obstacles. Firstly, available data are largely based on methylation differences measured in DNA obtained cross-sectionally at different ages throughout the life course, yet DNA methylation marks are known to vary by age. Secondly, although methylation is known to vary by cell and tissue types, measurements are made in accessible peripheral cell types accessible from otherwise healthy individuals, and do not always correlate with those of cell types that contribute to obesity. Thirdly, alteration to epigenetic marks can be caused by obesity, and this temporal ambiguity between exposure and outcome complicates causal inference. To overcome these obstacles, we will comprehensively identify regulatory DNA methylation for imprinted genes, creating the first draft of the human “imprintome”. Epigenetically regulated imprinted genes are estimated to comprise 1-2% (200-400 genes) of the human genome, and are critical in the development of the early embryo; however, only ~30 imprint control regions (ICRs), regulating 70-80 genes, are known. Monoallelic expression of imprinted genes is regulated by parent- of-origin specific DNA methylation at ICRs that is established prior to germ-layer specification and maintained in somatic tissues throughout life. Therefore, methylation marks regulating the expression of these genes are functionally relevant, and are conserved across cell types, among individuals, and throughout aging. These unique features of ICRs provide a means to a comprehensive tool for multiplexed measurement of early acquired epigenetic modifications, and assess their link between exposures and disease. Our overarching goal is to use genomewide approaches to systematically identify all ICRs using a wide variety of samples, including multiple cell types from males and females from a wide age range. In this way, identification can be restricted to only differentially methylated regions (DMRs) that are consistent across cell type, sex, and age – the hallmark of ICRs. The ICR panel will then be evaluated in relationship to obesity, by identifying, in umbilical cord blood at birth, ICR patterns predictive of obesity later in childhood. Identifying altered imprint regulation will provide markers for prospective risk assessment, identify mechanisms contributing to obesity development, and inform future research into environmental exposures affecting obesity. Once developed, this ICR screening assay would also then be used to identify regions of early epigenetic perturbation associated with any disease or exposure, creating new opportunities for understanding the fetal origins of these conditions.
项目总结/文摘

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Cathrine Hoyo其他文献

Cathrine Hoyo的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Cathrine Hoyo', 18)}}的其他基金

Prenatal stress and diet, and the fetal epigenome
产前压力和饮食,以及胎儿表观基因组
  • 批准号:
    10523353
  • 财政年份:
    2022
  • 资助金额:
    $ 56.78万
  • 项目类别:
Prenatal stress and diet, and the fetal epigenome
产前压力和饮食,以及胎儿表观基因组
  • 批准号:
    10665054
  • 财政年份:
    2022
  • 资助金额:
    $ 56.78万
  • 项目类别:
Southern Liver Health Cohort
南方肝脏健康队列
  • 批准号:
    10905062
  • 财政年份:
    2021
  • 资助金额:
    $ 56.78万
  • 项目类别:
Novel imprint control regions (ICRs) responsive to environmental exposures
响应环境暴露的新型印记控制区域(ICR)
  • 批准号:
    10296917
  • 财政年份:
    2021
  • 资助金额:
    $ 56.78万
  • 项目类别:
Southern Liver Health Cohort
南方肝脏健康队列
  • 批准号:
    10336820
  • 财政年份:
    2021
  • 资助金额:
    $ 56.78万
  • 项目类别:
Novel imprint control regions (ICRs) responsive to environmental exposures
响应环境暴露的新型印记控制区域(ICR)
  • 批准号:
    10655605
  • 财政年份:
    2021
  • 资助金额:
    $ 56.78万
  • 项目类别:
Characterizing the Human Imprint Regulatory Regions Associated with Childhood Obesity
表征与儿童肥胖相关的人类印记调节区域
  • 批准号:
    10442527
  • 财政年份:
    2019
  • 资助金额:
    $ 56.78万
  • 项目类别:
Characterizing the Human Imprint Regulatory Regions Associated with Childhood Obesity
表征与儿童肥胖相关的人类印记调节区域
  • 批准号:
    10180994
  • 财政年份:
    2019
  • 资助金额:
    $ 56.78万
  • 项目类别:
Characterizing the Human Imprint Regulatory Regions Associated with Childhood Obesity
表征与儿童肥胖相关的人类印记调节区域
  • 批准号:
    10011940
  • 财政年份:
    2019
  • 资助金额:
    $ 56.78万
  • 项目类别:
Follow-up and Maintenance of the Newborn Epigenetics STudy (NEST) Cohort
新生儿表观遗传学研究 (NEST) 队列的随访和维护
  • 批准号:
    10443683
  • 财政年份:
    2018
  • 资助金额:
    $ 56.78万
  • 项目类别:

相似海外基金

Understanding How Adolescent Bullying Experiences Affect Traumatic Stress,Sexual Health and STI Risk among Men Who Have Sex with Men (MSM)
了解青少年欺凌经历如何影响男男性行为者 (MSM) 的创伤性压力、性健康和性传播感染风险
  • 批准号:
    10553263
  • 财政年份:
    2022
  • 资助金额:
    $ 56.78万
  • 项目类别:
Understanding How Adolescent Bullying Experiences Affect Traumatic Stress,Sexual Health and STI Risk among Men Who Have Sex with Men (MSM)
了解青少年欺凌经历如何影响男男性行为者 (MSM) 的创伤性压力、性健康和性传播感染风险
  • 批准号:
    10347813
  • 财政年份:
    2022
  • 资助金额:
    $ 56.78万
  • 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
  • 批准号:
    10380686
  • 财政年份:
    2019
  • 资助金额:
    $ 56.78万
  • 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
  • 批准号:
    9888437
  • 财政年份:
    2019
  • 资助金额:
    $ 56.78万
  • 项目类别:
Visuocortical Dynamics of Affect-Biased Attention in the Development of Adolescent Depression
青少年抑郁症发展过程中情感偏向注意力的视觉皮层动力学
  • 批准号:
    10597082
  • 财政年份:
    2019
  • 资助金额:
    $ 56.78万
  • 项目类别:
Targeting maladaptive responding to negative affect in adolescent cannabis users
针对青少年大麻使用者的负面影响的适应不良反应
  • 批准号:
    9371970
  • 财政年份:
    2017
  • 资助金额:
    $ 56.78万
  • 项目类别:
Childhood positive affect and anger as predictors of adolescent risky behavior
童年积极影响和愤怒是青少年危险行为的预测因素
  • 批准号:
    9139461
  • 财政年份:
    2015
  • 资助金额:
    $ 56.78万
  • 项目类别:
Do State Marijuana Policies Affect Adolescent Marijuana and Alcohol Use?
州大麻政策会影响青少年大麻和酒精的使用吗?
  • 批准号:
    8783159
  • 财政年份:
    2014
  • 资助金额:
    $ 56.78万
  • 项目类别:
Do State Marijuana Policies Affect Adolescent Marijuana and Alcohol Use?
州大麻政策会影响青少年大麻和酒精的使用吗?
  • 批准号:
    8853783
  • 财政年份:
    2014
  • 资助金额:
    $ 56.78万
  • 项目类别:
Assessment of Affect Instability in Adolescent Girls with BPD Features
具有 BPD 特征的青春期女孩的情绪不稳定评估
  • 批准号:
    8122499
  • 财政年份:
    2011
  • 资助金额:
    $ 56.78万
  • 项目类别:
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了