Tumor-specific autoantibodies for SCLC early detection

用于 SCLC 早期检测的肿瘤特异性自身抗体

基本信息

项目摘要

ABSTRACT/SUMMARY Small cell lung cancer (SCLC) is one of the few malignancies with such poor outcomes that it meets the definition of a “recalcitrant” cancer, accounting for 30,000 American lives each year with five-year survival rates of just ~7%. Somewhat lost in these dismal statistics is the fact that patients diagnosed early (limited stage) display vastly superior survival metrics when compared to those diagnosed late (extensive stage). Unfortunately, only a minority of cases are identified at limited stage, and the computed tomography (CT) screening approaches capable of early detection for non-small cell lung cancer (NSCLC) have not proven effective for SCLC. We will employ a novel two-mode, array based, hybrid plasma marker methodology capable of detecting autoantibody- autoantigen complex and unbound autoantibody markers for SCLC early detection. One of the major problems with studying SCLC is there are few studies and cohorts that have appropriate plasma samples. We have accumulated robust biomarker candidates centered around autoantibody-antigen complexes using the Cardiovascular Health Study (prediagnostic), Fred Hutch Lung Cancer Early Detection and Prevention Clinic, and Vanderbilt SCLC sample sets and will comprehensively define free autoantibodies levels in these same cohorts. We propose to test a fixed combination rule combining both autoantibody approaches using all of the prediagnostic SCLC samples from the Women's Health Initiative (WHI), the Prostate, Lung, Colorectal, Ovarian Cancer Screening Trial (PLCO), and the National Lung Screening Trial (NLST) cohorts and diagnostic samples from Moffitt Cancer Center. Using prediagnostic samples allows us to effectively model early detection much more accurately than after diagnosis occurs, and this is particularly important for SCLC as diagnosis at the extensive stage is nearly almost always fatal. Part of our analysis will determine how early our autoantibody marker panel can predict the presence of SCLC and whether a tumor can be observed via CT at that time in order to evaluate the timing and implementation of our early-detection procedure.
抽象/总结

项目成果

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A McGarry Houghton其他文献

A McGarry Houghton的其他文献

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{{ truncateString('A McGarry Houghton', 18)}}的其他基金

Neutrophil derived proteinases abolish the IFNG signature in NSCLC
中性粒细胞衍生的蛋白酶消除 NSCLC 中的 IFNG 特征
  • 批准号:
    10717448
  • 财政年份:
    2023
  • 资助金额:
    $ 14.89万
  • 项目类别:
Anxa2 drives the function of immune suppressive neutrophils in lung cancer
Anxa2 驱动肺癌中免疫抑制性中性粒细胞的功能
  • 批准号:
    10310981
  • 财政年份:
    2021
  • 资助金额:
    $ 14.89万
  • 项目类别:
A Quantitative PET/CT Research Resource for Co-Clinical Imaging of Lung Cancer Therapies
用于肺癌治疗联合临床成像的定量 PET/CT 研究资源
  • 批准号:
    10301566
  • 财政年份:
    2021
  • 资助金额:
    $ 14.89万
  • 项目类别:
A Quantitative PET/CT Research Resource for Co-Clinical Imaging of Lung Cancer Therapies
用于肺癌治疗联合临床成像的定量 PET/CT 研究资源
  • 批准号:
    10700944
  • 财政年份:
    2021
  • 资助金额:
    $ 14.89万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10053675
  • 财政年份:
    2020
  • 资助金额:
    $ 14.89万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10259860
  • 财政年份:
    2020
  • 资助金额:
    $ 14.89万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10472743
  • 财政年份:
    2020
  • 资助金额:
    $ 14.89万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10601449
  • 财政年份:
    2020
  • 资助金额:
    $ 14.89万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10174875
  • 财政年份:
    2019
  • 资助金额:
    $ 14.89万
  • 项目类别:
Project 1: Targeting the Neutrophil Lineage To Enhance Immune Checkpoint Inhibitor Efficacy in NSCLC
项目1:靶向中性粒细胞谱系以增强非小细胞肺癌中免疫检查点抑制剂的功效
  • 批准号:
    10174872
  • 财政年份:
    2019
  • 资助金额:
    $ 14.89万
  • 项目类别:

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