Liquid biopsy of the lung to profile lung cancer

肺部液体活检以分析肺癌

基本信息

  • 批准号:
    10601449
  • 负责人:
  • 金额:
    $ 14.31万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-09-15 至 2025-08-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT A tumor biopsy is traditionally performed for lung cancer diagnosis using either bronchoscopy through the airway or a needle aspiration through the chest wall. Advances in targeted and immune therapies now often require more tissue for molecular and immune profiling to optimally manage lung cancer. The yield for cancer diagnosis using modern bronchoscopic tools approaches only 50% across the spectrum of lung tumors biopsied, and the additional requirement for molecular and immune profiling erodes this yield further. This leads to delayed and suboptimal care, increased healthcare costs, and increased patient morbidity since patients can often require multiple procedures to obtain the correct information for treatment. Our group has recently demonstrated that targeted Bronchoalveolar Lavage (BAL) – or a washing of the lung cancer performed during a procedure – is a reservoir of genomic and cellular biomarkers in the lung tumor macroenvironment (TMaE). Further, we have demonstrated that molecular analyses of BAL from the lung TMaE recapitulate cancer biology in the lung tumor microenvironment (TMiE). While BAL is very safe and routinely performed during bronchoscopy, to date, it is a pauci-cellular fluid that is of limited clinical utility for cancer diagnosis. Beyond cytology that is low yield, there are no molecular or cellular assays that are used in the clinic to fully inform providers who treat lung cancer. Because of this, rigorous attention to how methods of collection, patient host factors and processing of BAL will alter genomic and high dimensional cell based assays is lacking. Our central hypothesis is: BAL globally samples the tumor microenvironment (TMiE) to overcome limitations of tumor heterogeneity and is more sensitive than blood for immunogenomic profiling due to increased quantities of tumor specific biomarkers. To realize our goal and prove our hypothesis, in depth analysis of the conditions affecting BAL for high dimensional genome and cell assays is required. Here, we propose studying how basic conditions in the lung, variations in acquisition of BAL, and storage and processing of BAL affect its utility for comprehensive genome profiling and analysis of the T cell repertoire. Following identification of key pre-analytic variables, we propose a standard operating procedure for implementation in observational biomarker and first-in-man clinical trials to demonstrate the clinical utility of our approach. Proposal success will facilitate the introduction of novel molecular assays into the clinic that augment extant and developing blood and tumor assays. This approach will be particularly relevant as we move into the era of precision guided therapies for lung cancer treatment, which have begun to reduce mortality in even the most advanced stages, over the coming years and decades.
项目总结/文摘

项目成果

期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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A McGarry Houghton其他文献

A McGarry Houghton的其他文献

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{{ truncateString('A McGarry Houghton', 18)}}的其他基金

Neutrophil derived proteinases abolish the IFNG signature in NSCLC
中性粒细胞衍生的蛋白酶消除 NSCLC 中的 IFNG 特征
  • 批准号:
    10717448
  • 财政年份:
    2023
  • 资助金额:
    $ 14.31万
  • 项目类别:
Anxa2 drives the function of immune suppressive neutrophils in lung cancer
Anxa2 驱动肺癌中免疫抑制性中性粒细胞的功能
  • 批准号:
    10310981
  • 财政年份:
    2021
  • 资助金额:
    $ 14.31万
  • 项目类别:
A Quantitative PET/CT Research Resource for Co-Clinical Imaging of Lung Cancer Therapies
用于肺癌治疗联合临床成像的定量 PET/CT 研究资源
  • 批准号:
    10301566
  • 财政年份:
    2021
  • 资助金额:
    $ 14.31万
  • 项目类别:
A Quantitative PET/CT Research Resource for Co-Clinical Imaging of Lung Cancer Therapies
用于肺癌治疗联合临床成像的定量 PET/CT 研究资源
  • 批准号:
    10700944
  • 财政年份:
    2021
  • 资助金额:
    $ 14.31万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10053675
  • 财政年份:
    2020
  • 资助金额:
    $ 14.31万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10259860
  • 财政年份:
    2020
  • 资助金额:
    $ 14.31万
  • 项目类别:
Liquid biopsy of the lung to profile lung cancer
肺部液体活检以分析肺癌
  • 批准号:
    10472743
  • 财政年份:
    2020
  • 资助金额:
    $ 14.31万
  • 项目类别:
Administrative Core
行政核心
  • 批准号:
    10174875
  • 财政年份:
    2019
  • 资助金额:
    $ 14.31万
  • 项目类别:
Project 1: Targeting the Neutrophil Lineage To Enhance Immune Checkpoint Inhibitor Efficacy in NSCLC
项目1:靶向中性粒细胞谱系以增强非小细胞肺癌中免疫检查点抑制剂的功效
  • 批准号:
    10174872
  • 财政年份:
    2019
  • 资助金额:
    $ 14.31万
  • 项目类别:
Tumor-specific autoantibodies for SCLC early detection
用于 SCLC 早期检测的肿瘤特异性自身抗体
  • 批准号:
    10299616
  • 财政年份:
    2019
  • 资助金额:
    $ 14.31万
  • 项目类别:

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先进的机器学习使黑色素瘤和非小细胞肺癌的超灵敏液体活检成为可能
  • 批准号:
    10591304
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  • 批准号:
    10601270
  • 财政年份:
    2023
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    $ 14.31万
  • 项目类别:
Simple and Accessible Microfluidic Platform for Single Molecule Sequence Profiling of Tumor-derived DNA within Liquid Biopsies
简单易用的微流体平台,用于液体活检中肿瘤来源 DNA 的单分子序列分析
  • 批准号:
    10699214
  • 财政年份:
    2023
  • 资助金额:
    $ 14.31万
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Liquid biopsy and radiomics for liver cancer surveillance
用于肝癌监测的液体活检和放射组学
  • 批准号:
    10736720
  • 财政年份:
    2023
  • 资助金额:
    $ 14.31万
  • 项目类别:
Cell-free DNA Analysis for Liquid Biopsy of Cancer
用于癌症液体活检的游离 DNA 分析
  • 批准号:
    10818662
  • 财政年份:
    2023
  • 资助金额:
    $ 14.31万
  • 项目类别:
Establishing the clinical utility of cell-free tumor DNA methylation profiling as a reliable liquid biopsy approach in brain tumors
建立无细胞肿瘤 DNA 甲基化分析作为脑肿瘤可靠液体活检方法的临床实用性
  • 批准号:
    10280279
  • 财政年份:
    2022
  • 资助金额:
    $ 14.31万
  • 项目类别:
Establishing the clinical utility of cell-free tumor DNA methylation profiling as a reliable liquid biopsy approach in brain tumors
建立无细胞肿瘤 DNA 甲基化分析作为脑肿瘤可靠液体活检方法的临床实用性
  • 批准号:
    10594945
  • 财政年份:
    2022
  • 资助金额:
    $ 14.31万
  • 项目类别:
Lung Cancer, DNA Methylation, and Liquid Biopsy
肺癌、DNA 甲基化和液体活检
  • 批准号:
    10257798
  • 财政年份:
    2022
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    $ 14.31万
  • 项目类别:
A low-cost, multiplexed digital high resolution melt platform for DNA methylation-based detection and identification of cancers in liquid biopsies
一种低成本、多重数字高分辨率熔解平台,用于液体活检中基于 DNA 甲基化的癌症检测和识别
  • 批准号:
    10697370
  • 财政年份:
    2022
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    $ 14.31万
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術前liquid biopsyを用いたゲノム・RNA発現解析による肺癌術後の個別化医療の探索
通过术前液体活检进行基因组/RNA表达分析探索肺癌术后个体化医疗
  • 批准号:
    22K20788
  • 财政年份:
    2022
  • 资助金额:
    $ 14.31万
  • 项目类别:
    Grant-in-Aid for Research Activity Start-up
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