The impact of diet patterns and PUFA-related polymorphisms on ulcerative colitis in Hispanics
饮食模式和 PUFA 相关多态性对西班牙裔溃疡性结肠炎的影响
基本信息
- 批准号:10303059
- 负责人:
- 金额:$ 18.49万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2019
- 资助国家:美国
- 起止时间:2019-01-14 至 2023-11-30
- 项目状态:已结题
- 来源:
- 关键词:AdoptionAdultAffectAge of OnsetBiochemicalBiologicalChronicClinicClinicalColitisCollectionColonic inflammationCrohn&aposs diseaseDataDefecationDevelopmentDietDietary HistoryDietary InterventionDietary PracticesDietary QuestionnairesDietary intakeDiseaseDisease remissionEnzymesEuropeanFatty AcidsFecesFoodFrequenciesFutureGenerationsGenesGeneticGenetic PolymorphismGenetic Predisposition to DiseaseGenetic RiskGenetic VariationHemorrhageHeterogeneityHispanicHispanic AmericansHispanic PopulationsHospitalizationImmuneIncidenceIndividualInflammationInflammatoryInflammatory Bowel DiseasesIntakeIntervention StudiesLeukocyte L1 Antigen ComplexMeasuresMediatingMentorsMetabolicModelingN-3 polyunsaturated fatty acidNot Hispanic or LatinoOmega-3 Fatty AcidsOmega-6 Fatty AcidsParticipantPathway interactionsPatientsPatternPharmaceutical PreparationsPhenotypePolyunsaturated Fatty AcidsPrevalenceProspective StudiesQuestionnairesRecommendationRecurrent diseaseRegression AnalysisRelapseReportingReproducibilityResearchResearch PersonnelResourcesRiskRoleSeedsSeveritiesSeverity of illnessSurveysTestingTimeUlcerative ColitisUniversitiesVariantWorkbasebilingualismcareercohortdesigndietarydisease phenotypefatty acid biosynthesisfatty acid metabolismfollow-upgene environment interactiongenetic associationgenetic variantgenome sequencingindexingmicrobiome researchnovelpopulation basedprogramsrectalrelapse patientsrisk varianttoolwestern dietwhole genome
项目摘要
Summary
Ulcerative colitis (UC) is a devastating immune-mediated disease that is on the rise globally. In our prior study,
we found that Hispanics have less severe disease than non-Hispanics, but yet within one US-born generation
develop a disease course that is similar. Differences in adoption of a Western diet between US- born and
foreign-born Hispanics could explain differences in UC severity observed. A Western diet, high in n-6 to n-3
polyunsaturated fatty acids (PUFA), is up to 10-20 times the recommended intake and is considered pro-
inflammatory. However, heterogeneity of results in dietary intervention studies suggests that underlying genetic
variation in PUFA metabolism may modify diet effects. Our preliminary data indicates that Hispanics with UC
have polymorphisms in PUFA not present in Hispanic controls. In UC, disease activity measured by rectal
bleeding, number of bowel movements, and urgency correlates with endoscopic inflammation. I hypothesize
that Hispanics with UC whose diet follows a higher Western dietary pattern, defined by a reproducible dietary
pattern score, have more active disease, than those whose diet scores are lower. Further, I propose that
carriage of PUFA variants augments the effect of a Western diet on relapse leading to a disproportionate pro-
inflammatory effect of the diet. In this study, I examine the influence of a Western dietary pattern on remission
and relapse of UC among Hispanics (Aim 1). We will test whether PUFA variants influence relapse and
enhance the effect of a Western diet on UC relapse (Aim 2). A total of 320 self- identified, Hispanic participants
with UC are followed at our GI clinics and we will include these for our diet portion in Aim 1. We will include a
total of 691 Hispanics with UC and 900 Hispanic controls for our Aim 2 genetics portion. We have detailed
demographic and clinical information on these patients, as well as whole genome sequencing of PUFA
variants. Participants will be asked to complete a validated food-frequency dietary questionnaire, at baseline
and at 1-year follow up. Disease activity using the validated simple clinical colitis activity index will be assessed
at baseline and at 1 year follow up in combination with fecal calprotectin. We will calculate scores for a
Western dietary pattern and determine the influence of diet on relapse using multivariable regression analysis.
In Aim 2, we will examine the effect of PUFA variants on relapse and also determine gene-environment
interactions influencing disease activity between PUFA variants and Western diet. Results gathered from this
study will be a step towards personalizing IBD treatment by targeting specific dietary patterns in Hispanics with
highest metabolic genetic risk.
摘要:
--
溃疡性结肠炎(UC)是一种毁灭性的免疫介导性疾病,在全球范围内呈上升趋势。在我们之前的研究中,。
我们还发现,拉美裔美国人患上严重疾病的几率低于非拉美裔美国人,但仍不超过在美国出生的一代人。
在美国出生的美国人和中国人在采用西方传统饮食习惯方面存在差异。
在外国出生的拉美裔美国人无法解释观察到的UC严重程度的差异。西方人的饮食习惯,在6岁到3岁之间的摄入量很高。
多不饱和脂肪酸(PUFA),是推荐摄入量的10-20倍,被认为是支持的。
炎症性疾病。然而,饮食干预研究结果的异质性表明,潜在的遗传风险。
PUFA代谢水平的变化可能会改变饮食的影响。我们的初步数据显示,拉美裔美国人患有UC。
PUFA基因的多态性在拉美裔美国人中并不存在。在非UC患者中,他们的疾病和活动是通过直肠功能来衡量的。
出血、肠蠕动次数、疼痛和紧急程度与内窥镜下的炎症有关。我的假设是。
这就是西班牙裔美国人的情况,加州大学的饮食习惯遵循了西方人更高的饮食习惯模式,这种模式的定义是一种更具可重复性的饮食习惯。
在得分模式上,他们患上了更活跃的疾病,而不是那些饮食习惯得分更低的人。此外,我建议你这样做。
PUFA基因变体的携带增加了西方饮食习惯对癌症复发的影响,导致人们变得不成比例地支持
炎症性饮食的影响。在这项研究中,我将研究西方饮食模式对病情缓解的影响。
以及加州大学伯克利分校在拉美裔美国人中的复发风险(目标1)。我们将继续测试PUFA的变异是否会影响复发。
增强西式饮食习惯对UC复发的影响(目标2)。总共有32万人自我确认,包括西班牙裔参与者。
有了UC,我们的所有GI诊所都会遵循这些建议,我们将不会将这些计划包括在Aim 1中,以确保我们的日常饮食和部分健康。我们将不会包括这些计划。
总共有691名拉美裔美国人与加州大学洛杉矶分校合作,约900名拉美裔美国人参与控制,以实现我们的目标--遗传学部分。我们将提供详细信息。
这些患者的人口学特征和临床特征信息,以及PUFA的全基因组测序结果。
变种。这些参与者将被要求完成一份经过验证的食物频率和饮食习惯调查问卷,调查对象为基线。
并在至少1年内进行随访。疾病活动将使用经过验证的简单临床结肠炎活动指数量表进行评估。
在基线测试和第一年的测试中,我们将结合粪便中的钙保护素进行随访。我们将不会计算一年中的测试分数。
西方国家的饮食习惯模式通过多因素回归分析确定了饮食习惯对复发的影响程度。
在目标2中,我们将不仅研究PUFA基因变异对复发的影响,还将确定基因-环境。
影响疾病和活动的相互作用--PUFA基因变体和西方饮食之间的相互作用。他们的结果收集自本周的研究。
这项研究将是朝着实现IBD治疗方案个性化迈出的一大步,方法是针对拉美裔患者的特定饮食习惯模式。
代谢和遗传风险最高。
项目成果
期刊论文数量(0)
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Oriana Mazorra Damas其他文献
Oriana Mazorra Damas的其他文献
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{{ truncateString('Oriana Mazorra Damas', 18)}}的其他基金
The impact of diet patterns and PUFA-related polymorphisms on ulcerative colitis in Hispanics
饮食模式和 PUFA 相关多态性对西班牙裔溃疡性结肠炎的影响
- 批准号:
10063510 - 财政年份:2019
- 资助金额:
$ 18.49万 - 项目类别:
The impact of diet patterns and PUFA-related polymorphisms on ulcerative colitis in Hispanics
饮食模式和 PUFA 相关多态性对西班牙裔溃疡性结肠炎的影响
- 批准号:
10852474 - 财政年份:2019
- 资助金额:
$ 18.49万 - 项目类别:
The impact of diet patterns and PUFA-related polymorphisms on ulcerative colitis in Hispanics
饮食模式和 PUFA 相关多态性对西班牙裔溃疡性结肠炎的影响
- 批准号:
10528451 - 财政年份:2019
- 资助金额:
$ 18.49万 - 项目类别:
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